Taltz
Taltz (ixekizumab) is an injection that's given under the skin. It helps treat inflammatory conditions, including plaque psoriasis, psoriatic arthritis, and some types of arthritis in the spine. This medication works as an interleukin antagonist to lessen inflammation in the body. You inject Taltz (ixekizumab) once a month using the prefilled syringe or autoinjector. The dose depends on the health problem you're treating. Side effects include upper respiratory infections. You also might feel pain or have redness around the injection area. Taltz (ixekizumab) is a brand-name medication.
What is Taltz (ixekizumab)?
What is Taltz (ixekizumab) used for?
- Moderate-to-severe plaque psoriasis in people 6 years and older
- Psoriatic arthritis in adults
- Ankylosing spondylitis in adults
- Non-radiographic axial spondyloarthritis in adults
How Taltz (ixekizumab) works
Taltz (ixekizumab) is a type of monoclonal antibody called an interleukin antagonist.
It attaches to proteins in your immune system called interleukin-17 (IL-17). These proteins play a role in causing inflammation in the body.
By attaching to IL-17, Taltz (ixekizumab) blocks the proteins from working. This helps lower inflammation related to psoriasis and some types of arthritis.
Drug facts
More on Taltz (ixekizumab) essentials
Side effects of Taltz (ixekizumab)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Reaction at the injection site (e.g., redness, pain; 17%)
- Upper respiratory tract infections (14%)
Less Common Side Effects
- Nausea
- Fungal infection
Note: Side effects were reported by adults with plaque psoriasis. Side effects might be a little different for children or for people with other autoimmune conditions.
Taltz (ixekizumab) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reaction: trouble breathing; hives; swelling of your face, lips, tongue, or throat
- Infection: fever; cough; trouble breathing; diarrhea; weakness; night sweats; chills; scaly, itchy, or burning skin; yellowish patches in the mouth; stringy eye discharge
- Stomach problems: severe stomach pain, diarrhea or constipation that doesn't get better, bloody stools
The following Taltz (ixekizumab) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Dry, itchy, scaly patches of skin that blister or peel
- Infection—fever, chills, cough, sore throat, wounds that don't heal, pain or trouble when passing urine, general feeling of discomfort or being unwell
- Sudden or severe stomach pain, bloody diarrhea, fever, nausea, vomiting
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Nausea
- Pain, redness, or irritation at injection site
- Runny or stuffy nose
- Sore throat
Get your GoodRx coupon
Pros and cons of Taltz (ixekizumab)
Pros
- Generally given once a month (might need some starter doses)
- Available as a prefilled syringe or autoinjector for easier use
- Can inject at home after a healthcare professional trains you (for most people)
Cons
- Only given as an injection under the skin
- Raises the risk of infections
- Might cause flare-ups in people with Crohn's disease or ulcerative colitis
Pharmacist tips for Taltz (ixekizumab)
- Put reminders on your calendar for your Taltz (ixekizumab) injections. In general, it's injected every 4 weeks. For adults with plaque psoriasis, you start off with injections every 2 weeks for a few months before you go to every 4 weeks. If you have questions about your dosing schedule, talk to your care team.
- If you miss a dose of Taltz (ixekizumab), inject it as soon as you remember. Then, you can continue with your usual dosing schedule.
- Call your care team if you think you have an infection while taking Taltz (ixekizumab). This medication can make it harder for your body to fight it. Your care team can see if the infection needs to get treated. If the infection gets serious or if treatment doesn't help, you might need to stop Taltz (ixekizumab) until you get better.
- Before getting any vaccines, tell the healthcare professional that you're taking Taltz (ixekizumab). Most vaccines are okay to get while you're taking this medication. But others, like live vaccines, might not be. The healthcare professional can check to make sure the vaccine is safe for you.
- If you're pregnant, thinking of becoming pregnant, or breastfeeding, talk to your prescriber. They can help explain the risks and benefits of taking Taltz (ixekizumab). It's not known how safe it is to use while pregnant or breastfeeding. Your prescriber can help you decide the safest option for you and your baby.
Tips for how to use and how to inject Taltz (ixekizumab):
- Make sure you know how to use and inject Taltz (ixekizumab). Your care team will train you before they let you do it on your own at home. But also read the directions for the autoinjector or prefilled syringe (whichever one you have). Ask your care team if you have any questions on how to use this medication.
- How to store Taltz (ixekizumab): Keep the medication in the refrigerator, but be careful not to freeze it. You can also keep it at room temperature up to 86ºF for up to 5 days. Write down the date you took it out of the fridge to help you remember. Once it reaches room temperature, don't put it back in the refrigerator. Keep the medication in its carton to protect it from light.
- When you're ready for your Taltz (ixekizumab) injection: Take a prefilled syringe or autoinjector out of the carton. Lay it on a flat surface to warm up to room temperature. This should take about 30 minutes. Don't try to warm it up any other way, like using a microwave or running under hot water. Don't shake the medication either. This can damage it.
- Right before you inject Taltz (ixekizumab): Always check that the medication inside prefilled syringe or autoinjector. It should be clear and colorless to slightly yellow. Don't use it if it's cloudy or discolored. Also don't use it if it has particles in it. Use a new one, or call your prescriber or pharmacist for a replacement if needed.
- Where to inject Taltz (ixekizumab): Inject under the skin into your thigh or stomach (at least 1 inch away from your belly button). You can also ask someone to help inject the medication into the back of your upper arm. Be sure to choose a different spot for every injection. Also don't inject into any area that's red, bruised, scaly, tender, or hard. This can help prevent skin irritation.
- How to inject Taltz (ixekizumab) using the autoinjector: Take off the base cap and hold the clear base flat against your skin at the injection site. Then, unlock it and press the green injection button. You'll hear a click when your injection starts. Keep holding the autoinjector in place until you hear a second click. This should be about 10 seconds later, telling you the injection is done. You should see the gray plunger through the clear base.
- How to inject Taltz (ixekizumab) using the prefilled syringe: Carefully pull the cap off the needle. Gently pinch and hold a fold of skin at the injection site. Then, insert the needle at a 45-degree angle. Let go of your skin, and slowly push the plunger on the syringe all the way down to inject the medication. You should see the green plunger rod show up inside the syringe when the injection is done. Then, gently remove the needle from your skin.
- How to throw away Taltz (ixekizumab) after each injection: Place used autoinjectors and prefilled syringes in a sharps container. You can also use a heavy-duty plastic container like an empty milk carton or laundry detergent bottle. Don't throw them away into your trash can. This helps keep you and others safe from needle sticks.
Common questions about Taltz (ixekizumab)
Yes, Taltz (ixekizumab) is a type of biologic medication. Biologics are medications that are made from living sources, like cells, in a lab. Taltz (ixekizumab) is a monoclonal antibody, which is a protein made from cells in a lab. It works by blocking certain proteins that cause inflammation (swelling) in your body. This helps lessen inflammation to treat different inflammatory problems.
Some people might think of Taltz (ixekizumab) as an immunosuppressant. The medication works by blocking a protein in your immune system. This helps lessen inflammation from certain autoimmune problems. But as a consequence, it can make it harder for your body to fight germs and raise your risk of infections.
Taltz (ixekizumab) doesn't seem to cause cancer. A study in 2025 showed that people who took this medication for psoriatic arthritis or arthritis in the spine didn't have a higher risk of cancer. If you have more questions about this, ask your prescriber.
No. In studies, people who took Taltz (ixekizumab) didn't say that their weight went up. If you notice you're gaining weight while taking this medication and you don't know why, talk to your primary care provider.
Yes, Taltz (ixekizumab) can cause injection site reactions. It's common to feel some pain or see some redness around the injection area. But the area could also swell a little or get itchy. Most times, these reactions appear within a few hours after the injection. But they usually go away on their own after a day or two. In the meantime, you can cover the area with an ice pack wrapped in a towel for 10 minutes. If the reaction bothers you a lot or if it doesn't go away on its own, let your prescriber know. They can find other ways to help you.
It's best to keep Taltz (ixekizumab) in the refrigerator. But if you need to, you can leave the medication out of the fridge and at room temperature for up to 5 days. It might be helpful to write the date on the box so you remember when you took it out of the fridge. Throw it away in a sharps container after 5 days if you haven't used it yet. Once the medication reaches room temperature, you can't put it back in the fridge.
No. Taltz (ixekizumab) and Skyrizi (risankizumab) are completely different medications. They're both injectable biologics that lower inflammation in your body, but they work in slightly different ways. Both medications can help with plaque psoriasis and psoriatic arthritis. But they have other unique uses. Taltz can also treat certain types of arthritis in the spine. And Skyrizi can also help with inflammatory gut problems (Crohn's disease and ulcerative colitis). What's more, how often injections are given is different. Taltz is generally injected under the skin every 4 weeks. But Skyrizi is injected every 4, 8, or 12 weeks, depending on the condition you're treating and where you are in your treatment. Talk to your prescriber to compare the medications and see which one is right for you.
Taltz (ixekizumab) and Humira (adalimumab) are both injectable biologics. They work in different ways to lower inflammation in the body to treat certain conditions. Both can help with plaque psoriasis, psoriatic arthritis, and arthritis in the spine. But Humira can also help with many other conditions, like rheumatoid arthritis and Crohn's disease. What's more, Taltz and Humira are both injections under the skin. But their dosing schedules are different. Taltz is usually injected every 4 weeks. And Humira is given every 1 or 2 weeks, depending on the treatment plan. Talk to your prescriber to compare these medications and decide which might be right for you.
How to save using GoodRx
Risks and warnings for Taltz (ixekizumab)
Taltz (ixekizumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Risk of infection
- Risk factors: Active, chronic, or recurrent infection
Taltz (ixekizumab) can make it harder for your body to fight off germs. This can raise your risk of getting a bacterial, viral, or fungal infection. Examples include upper respiratory tract infections, pink eye, and oral thrush. Sometimes, infections can become serious.
Before starting Taltz (ixekizumab), you'll need to get tested for tuberculosis (TB). This is because it's possible for the medication to make an old TB infection come back. Don't take Taltz (ixekizumab) if you currently have TB. If you have or have had TB, you might need to get treated for it before you start Taltz (ixekizumab).
Call a healthcare professional if you think you have an infection while taking Taltz (ixekizumab). Look out for a fever, cough, trouble breathing, weakness, night sweats, and chills. Your care team can check to see if you have an infection. If you do, you might have to stop taking Taltz (ixekizumab) until you get better.
Caution when getting vaccines
It's best to be up to date on all your vaccines before you start Taltz (ixekizumab). If you need to get one during treatment, tell the healthcare professional you're taking Taltz (ixekizumab). They can make sure the vaccine is safe for you to get.
You should avoid live vaccines while you're taking Taltz (ixekizumab). It's not known if these types of vaccines are safe during treatment. Examples of live vaccines include MMR (measles, mumps, and rubella vaccine) and FluMist (nasal spray flu vaccine).
Eczema-like skin reaction
Some people who took Taltz (ixekizumab) had severe skin reactions that looked like eczema. This can look like dry, itchy, inflamed, and red skin. Sometimes, it can be small, itchy blisters on the palm of your hands or the bottom of your feet. This has happened from a few days to months after the first dose of Taltz (ixekizumab).
Talk to your prescriber if you have unusual changes in your skin while taking Taltz (ixekizumab). They can help you manage this side effect. It might mean taking a break from the medication until the skin problem goes away.
Allergic reaction
It's possible to have a serious allergic reaction to Taltz (ixekizumab). These allergic reactions can include swelling of your face, lips, tongue, or throat. It can also look like trouble breathing, hives, or any other sign of anaphylaxis. If you have an allergic reaction to Taltz (ixekizumab) at any time, get medical help right away.
Inflammatory bowel disease
People treated with Taltz (ixekizumab) might be at a higher risk of inflammatory bowel disease (IBD). In studies, some people who took this medication had new or worsening IBD (flare-ups).
Before you start Taltz (ixekizumab), tell your prescriber if you have Crohn's disease or ulcerative colitis. Let your care team know if you have severe stomach pain or bloody stools while taking Taltz (ixekizumab). Also tell them if you have diarrhea or constipation that doesn't get better. These could be signs of IBD.
Taltz (ixekizumab) dosage
Carton| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 1 syringe of 40mg/0.5ml | 1 carton | $7,325.85 | $7,325.85 |
| 1 syringe of 20mg/0.25ml | 1 carton | $7,325.85 | $7,325.85 |
Typical dosage for Taltz (ixekizumab)
Taltz (ixekizumab) is given as an injection under the skin. It's injected into the stomach, thighs, or back of the upper arms.
The dose depends on the inflammatory condition you're treating.
-
Plaque psoriasis
- Age 18 years and older: The typical starting dose is 160 mg as a single dose, then 80 mg every 2 weeks for 12 weeks. After that, the typical maintenance dose is 80 mg every 4 weeks.
- Age 6 to under 18 years: The dose is based on your child's weight.
- Weigh greater than 110 lbs: The typical dose is 160 mg as a single dose, then 80 mg every 4 weeks.
- Weigh 55 to 110 lbs: The typical dose is 80 mg as a single dose, then 40 mg every 4 weeks.
- Weigh less than 55 lbs: The typical dose is 40 mg as a single dose, then 20 mg every 4 weeks. A trained healthcare professional will help inject the medication.
-
Psoriatic arthritis or ankylosing spondylitis
- Age 18 years and older: The typical dose is 160 mg as a single dose, then 80 mg every 4 weeks.
-
Non-radiographic axial spondyloarthritis
- Age 18 years and older: The typical dose is 80 mg every 4 weeks.
More on Taltz (ixekizumab) dosage
How much does Taltz (ixekizumab) cost?
$7,325.85
What are alternatives to Taltz (ixekizumab)?
News about Taltz (ixekizumab)
Taltz (ixekizumab) images
