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Taltz Coupon - Taltz 1 autoinjector of 80mg/ml carton

Taltz

ixekizumab
Used for Plaque Psoriasis, Psoriatic Arthritis, Non-radiographic Axial Spondyloarthritis, Ankylosing Spondylitis
Used for Plaque Psoriasis, Psoriatic Arthritis, Non-radiographic Axial Spondyloarthritis, Ankylosing Spondylitis

Taltz (ixekizumab) is a monoclonal antibody known as an interleukin antagonist. It's used to treat inflammatory problems, including plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and non-radiographic axial spondyloarthritis. Taltz (ixekizumab) is available as a prefilled syringe and prefilled autoinjector. It's given as an injection under the skin once per month. Side effects include upper respiratory infections and injection-site reactions (e.g., pain, redness).

Last reviewed on January 21, 2024
basics-icon

What is Taltz (ixekizumab)?

What is Taltz (ixekizumab) used for?

  • Moderate-to-severe plaque psoriasis in people ages 6 years and older

  • Psoriatic arthritis (PsA) in adults

  • Ankylosing spondylitis (AS) in adults

  • Non-radiographic axial spondyloarthritis (nr-axSpA) in adults

How Taltz (ixekizumab) works

Taltz (ixekizumab) is a monoclonal antibody that works as an interleukin antagonist. It attaches to certain proteins in your immune system called interleukin-17 (IL-17) that play a role in causing inflammation. By attaching to IL-17, the medication blocks the proteins from working, which helps lower inflammation.

Drug Facts

Common BrandsTaltz
Drug ClassInterleukin antagonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Taltz (ixekizumab) essentials

basics-icon

What are the side effects of Taltz (ixekizumab)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Other Side Effects

  • Nausea
  • Fungal infection
Note: Side effects were reported by adults with plaque psoriasis. Side effects might slightly differ for children or for people with other autoimmune conditions.

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reactions: trouble breathing; hives; swelling of your face, lips, tongue, or throat
  • Infection: fever; cough; trouble breathing; diarrhea; weakness; night sweats; chills; scaly, itchy, or burning skin

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Taltz (ixekizumab)

thumbs-up

Pros

Given once per month (after the first few doses)

Available as a prefilled syringe or autoinjector for easier use

Can inject at home after proper training

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Cons

Only given as an injection under the skin

Raises the risk of infections

Might cause flare ups in people with Crohn's disease or ulcerative colitis

pharmacist-tips

Pharmacist tips for Taltz (ixekizumab)

pharmacist
  • Tell your provider or pharmacist that you're taking Taltz (ixekizumab) before you get any vaccines. Most vaccines are okay to get while you're taking this medication, but others, like live vaccines, might not be. Your providers can make sure you can get the vaccine you want.

    • Store Taltz (ixekizumab) in the carton it came in to protect it from light and place it in the refrigerator; be careful not to freeze the medication. You can also keep it at room temperature for up to 5 days; make sure to write down the new expiration date if you do.

      • If you miss a dose of Taltz (ixekizumab), take the medication as soon as possible. Then, continue with your usual dosing schedule.

        • Talk to your provider if you're pregnant or thinking of becoming pregnant. It's not known how safe Taltz (ixekizumab) is during pregnancy. If you're pregnant and you're taking this medication, it's recommended that you call 1-800-284-1695 to enroll in a registry that monitors you and your baby during treatment.

          • Don't breastfeed while you're taking Taltz (ixekizumab) unless your provider says it's safe to do so. There's not a lot of information about whether this medication is safe for you or your baby if you breastfeed.

            Tips for injecting [Taltz (ixekizumab) under the skin at home:

            • Make sure you know how to properly and safely inject Taltz (ixekizumab) to avoid accidentally hurting yourself or wasting the medication. Carefully read the directions for using the autoinjector or prefilled syringe (whichever one you have). Ask your provider or pharmacist if you have any questions on how to use this medication.

              • When you're ready for your dose, take the Taltz (ixekizumab) syringe or autoinjector out of the carton and lay it on a flat surface to warm up. This should take about 30 minutes. Don't try to warm up the medication any other way (e.g., microwave, under hot water) because this can damage it. Don't shake the medication either.

                • Before you inject, always check that the medication inside is clear and colorless to slightly yellow. Don't use it if it's cloudy or discolored or if it has particles in it. Call your provider or pharmacist about a replacement.

                  • Inject Taltz (ixekizumab) under the skin into your thighs or stomach (at least 1 inch away from your belly button). You can also ask someone to help inject the medication into the back of your arms.

                    • Be sure to rotate injection sites for every injection. Don't inject into any area that's red, bruised, scaly, tender, or scarred or has stretch marks.

                      • For the autoinjector: Remove the cap and hold the autoinjector flat against your skin at the injection site. Then, unlock your device and press the green injection button. You'll hear a click when your injection starts; make sure you hold the device in place until you hear a second click. The second click usually takes about 10 seconds and means that your injection is complete.

                        • For the prefilled syringe: Remove the cap off the needle. Gently pinch and hold a fold of skin at the injection site, and insert the needle at a 45-degree angle. Let go of your skin, and slowly push the plunger on the syringe down to inject the medication. You should see the green plunger rod show up inside the syringe when the injection is complete.

                          • After your injection, place the used autoinjector or prefilled syringe in a sharps container or a heavy-duty plastic container (e.g., empty milk carton, laundry detergent bottle). This lowers the risk for needle-stick injuries. Don't throw them away into your trash can. Visit the FDA's website for guidance on how to safely throw away your sharps container in your specific state.

                            faqs

                            Frequently asked questions about Taltz (ixekizumab)

                            Is Taltz (ixekizumab) a biologic?
                            Yes, Taltz (ixekizumab) is a type of biologic medication. Biologics are medications that are made from living sources, like cells, in the lab. Taltz (ixekizumab) is a monoclonal antibody, which is a lab-made protein that's made from cells. It's made to help block inflammation in your body to relieve symptoms of different inflammatory problems.
                            Is Taltz (ixekizumab) an immunosuppressant?
                            Taltz (ixekizumab) can be considered an immunosuppressant. The medication treats certain inflammatory problems by blocking a protein in your immune system that makes it less active. But in the process, Taltz (ixekizumab) can weaken your immune system and raise your risk for infections.
                            How long does it take for Taltz (ixekizumab) to work?
                            It depends on what medical condition you're taking Taltz (ixekizumab) for. Studies show that there was symptom improvement within 3 months for some adults and 1 month for some children with plaque psoriasis. Other studies show that the medication can help improve symptoms as early as within 1 week for some adults with psoriatic arthritis and within 2 weeks for some adults with ankylosing spondylitis or non-radiographic axial spondyloarthritis. Keep in mind that everyone responds to Taltz (ixekizumab) differently. So make sure to follow up with your provider about how well the medication is working for your condition.
                            Do Taltz (ixekizumab) injections hurt?
                            It depends. Everyone can respond differently to pain. This means that Taltz (ixekizumab) injections might hurt for some people, while others might not feel any pain at all. Keep in mind that one of the most frequent injection-site reactions from Taltz (ixekizumab) that was reported in clinical studies was pain. But injection-site reactions were mostly mild to moderate, and no one stopped taking Taltz (ixekizumab) because of pain. Talk to your provider if you feel pain from Taltz (ixekizumab) injections that's too much to handle.
                            Does Taltz (ixekizumab) cause hair loss?
                            No, hair loss wasn't a side effect that was reported by people who used Taltz (ixekizumab) during clinical trials. Contact your provider if you notice hair loss while you're taking this medication. Your provider can examine you for possible causes for any hair loss.
                            How long does Taltz (ixekizumab) stay in your system?
                            It takes about 2 months for most of Taltz (ixekizumab) to leave your body after a single dose. This time-frame is estimated based on the half-life of Taltz (ixekizumab). If you're having side effects, they might last as long as it takes for the medication to clear your system.
                            How long can Taltz (ixekizumab) be unrefrigerated?
                            It's best to store Taltz (ixekizumab) in the refrigerator because the medication can last longer. But if you don't have access to a refrigerator for a short period of time, you can leave the medication at room temperature for up to 5 days. It might be helpful to write the date on the box so you remember when you took Taltz (ixekizumab) out of the fridge. Throw it away in a sharps container after 5 days if it hasn't been used. Once the medication reaches room temperature, you can't put it back in the fridge.
                            What's the difference between Taltz (ixekizumab) and Cosentyx?
                            Both Taltz (ixekizumab) and Cosentyx (secukinumab) are monoclonal antibodies that work by blocking interleukin-17 (IL-17). They can treat some of the same inflammatory problems, such as plaque psoriasis and psoriatic arthritis. But Cosentyx can be used for a few other conditions, including a certain kind of childhood arthritis and hidradenitis suppurativa. While both medications can be given as an injection under the skin, Cosentyx can also be given as an infusion into the veins by a healthcare provider. Note that a small study comparing the medications showed no difference in safety or how well they work for psoriasis. Another study showed that people with psoriatic arthritis who previously had no improvement with Cosentyx were successfully treated with Taltz. Your provider will discuss with you about which medication best fits your needs.
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                            What are the risks and warnings for Taltz (ixekizumab)?

                            Taltz (ixekizumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                            risk-warning

                            Infections

                            • Risk factors: Active, chronic, or recurrent infection | Having other conditions that raise your risk of infection

                              Taltz (ixekizumab) can affect your body's ability to fight off germs and raise your risk for bacterial, viral, or fungal infections. In clinical studies, people most commonly reported upper respiratory infections and fungal infections.

                              Taltz (ixekizumab) might also cause tuberculosis (TB). This can be either a new TB infection or an old one that's come back. Because of this risk, you'll need to get tested for TB before you start this medication and get treated if it's confirmed that you have TB. Tell your provider about your medical conditions and medications to make sure Taltz (ixekizumab) is safe to take.

                              Contact your provider if you develop symptoms of an infection, such as fever; cough; trouble breathing; diarrhea; weakness; night sweats; chills; or itchy, scaly, or burning skin. Your provider can examine you to see whether you have an infection. If you do, you might have to stop taking Taltz (ixekizumab) so your body can fight the infection.

                              risk-warning

                              Caution when getting vaccines

                              Tell your provider or pharmacist that you're taking Taltz (ixekizumab) before you get any vaccines. You should avoid getting live vaccines while you're taking Taltz (ixekizumab). It's not known whether these types of vaccines are safe to get during treatment. Examples of live vaccines include Varivax (chickenpox vaccine) and MMR (measles, mumps, and rubella vaccine). It's best to be up to date on all your vaccines before you start Taltz (ixekizumab).

                              risk-warning

                              Allergic reaction

                              It's possible to have a serious allergic reaction to Taltz (ixekizumab). These allergic reactions can include trouble breathing; hives; swelling of your face, lips, tongue, or throat; or any other symptom of anaphylaxis. Get medical help right away if you have an allergic reaction to Taltz (ixekizumab) at any time during treatment.

                              risk-warning

                              Inflammatory bowel disease

                              People treated with Taltz (ixekizumab) might be at higher risk for inflammatory bowel disease (IBD). In clinical studies, some people who took Taltz (ixekizumab) had new or worsening IBD (i.e., flare-ups). Before you start this medication, let your provider know if you have a history of IBD. Contact your provider if you have stomach pain, bloody stools, diarrhea or constipation that doesn't get better, or sudden weight loss while you're taking Taltz (ixekizumab). These might be signs of IBD.

                              dosage

                              Taltz (ixekizumab) dosage forms

                              Typical dosing for Taltz (ixekizumab)

                              Taltz (ixekizumab) is given as an injection under the skin in the stomach, thighs, or back of the upper arms.

                              Plaque psoriasis

                              • Age 18 years and older: The typical starting dose is 160 mg as a single dose, then 80 mg every 2 weeks for 12 weeks. After that, the typical maintenance dose is 80 mg every 4 weeks.

                              • Age 6 to under 18 years: The dose is based on your child's weight.

                                • Weight of greater than 110 lbs: The typical dose is 160 mg as a single dose, then 80 mg every 4 weeks.

                                • Weight of 55 to 110 lbs: The typical dose is 80 mg as a single dose, then 40 mg every 4 weeks.

                                • Weight of less than 55 lbs: The typical dose is 40 mg as a single dose, then 20 mg every 4 weeks.

                              Psoriatic arthritis or ankylosing spondylitis

                              • Age 18 years and older: The typical dose is 160 mg as a single dose, then 80 mg every 4 weeks.

                              Non-radiographic axial spondyloarthritis

                              • Age 18 years and older: The typical dose is 80 mg every 4 weeks.

                              More on Taltz (ixekizumab) dosage forms

                              alternatives

                              What are alternatives to Taltz (ixekizumab)?

                              There are a number of medications that your doctor can prescribe in place of Taltz (ixekizumab). Compare a few possible alternatives below.
                              Taltz (ixekizumab)
                              Used for:
                              • Moderate-to-severe plaque psoriasis in people ages 6 years and older

                              • Psoriatic arthritis (PsA) in adults

                              • Ankylosing spondylitis (AS) in adults

                              • Non-radiographic axial spondyloarthritis (nr-axSpA) in adults

                              Used for:
                              • Moderate-to-severe plaque psoriasis, in people who might benefit from systemic therapy (e.g., pills or injections) or treatment using ultraviolet (UV) light

                              • Active psoriatic arthritis

                              $14534.63 Lowest GoodRx priceView Prices
                              Used for:
                              $7820.83 Lowest GoodRx priceView Prices
                              latest news

                              What is the latest news about Taltz (ixekizumab)?

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                              References

                              Best studies we found

                              Berman, J., et al. (2021). Treatment with ixekizumab following secukinumab failure in patients with psoriatic arthritis: Real-life experience from a resistant population. Biologics: Targets & Therapy.

                              Deodhar, A. (2019). What is non-radiographic axial spondyloarthritis? Spondylitis Association of America.

                              Drugs and Lactation Database (LactMed®). (2023). Ixekizumab. National Institute of Child Health and Human Development. 

                              View All References (11)

                              Eli Lilly and Company. (2021). Instructions for use: How to use the Taltz prefilled syringe.

                              Eli Lilly and Company. (2023). Instructions for use: Taltz® [tol-t-s] (ixekizumab) injection for subcutaneous use - Autoinjector.

                              Eli Lilly and Company. (2024). Taltz- ixekizumab injection, solution [package insert]. DailyMed.

                              Gordon, K. B., et al. (2016). Phase 3 trials of ixekizumab in moderate-to-severe plaque psoriasis. The New England Journal of Medicine.

                              Herrera-Acosta, E., et al. (2020). Comparative study of the efficacy and safety of secukinumab vs ixekizumab in moderate-to-severe psoriasis after 1 year of treatment: Real-world practice. Dermatologic Therapy.

                              Nemours KidsHealth. (2021). Enthesitis-related juvenile arthritis.

                              Paller, A. S., et al. (2020). Efficacy and safety of ixekizumab in a phase III, randomized, double-blind, placebo-controlled study in paediatric patients with moderate-to-severe plaque psoriasis (IXORA-PEDS). The British Journal of Dermatology.

                              St Clair-Jones, A., et al. (2020). Understanding and minimising injection-site pain following subcutaneous administration of biologics: A narrative review. Rheumatology and Therapy.

                              U.S. Food and Drug Administration. (2021). Safely using sharps (needles and syringes) at home, at work and on travel.

                              van der Heijde, D., et al. (2018). Efficacy and safety of ixekizumab in patients with active psoriatic arthritis: 52-week results from a phase III study (SPIRIT-P1). The Journal of Rheumatology.

                              Zenobia, C., et al. (2015). Basic biology and role of interleukin-17 in immunity and inflammation. Periodontology 2000.

                              GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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