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HomeDrugsHumira (adalimumab) Prices

Humira

adalimumab

Used for Psoriasis, Plaque Psoriasis, Ulcerative Colitis, Rheumatoid Arthritis, Psoriatic Arthritis, Crohn's Disease, Uveitis, Ankylosing Spondylitis, Hidradenitis Suppurativa, Juvenile Idiopathic Arthritis

Humira (adalimumab) is an injectable medication used for treating many different autoimmune conditions, including rheumatoid arthritis (RA), Crohn's disease (CD), ulcerative colitis (UC), and plaque psoriasis. It's usually given every other week, and it can be used alone or taken with methotrexate or other non-biologic medications. This medication is available as many different brands (or biosimilars).

Reviewed by:

Hope Chang, PharmD, AAHIVP

Kristianne Hannemann, PharmD

Last reviewed on December 14, 2022

Basics Side effects Pros & cons Pharmacist tips FAQs Warnings Dosage Interactions Cost Alternatives Latest news Images Prices Medicare

What is Humira (adalimumab)?

What is Humira (adalimumab) used for?

Rheumatoid arthritis (RA) - adults only
Juvenile idiopathic arthritis (JIA) - people age 2 and older
Psoriatic arthritis (PsA) - adults only
Ankylosing spondylitis (AS) - adults only
Crohn's disease (CD) - people age 6 and older
Ulcerative colitis (UC) - people age 5 and older
Plaque psoriasis - adults only
Hidradenitis suppurativa (HS) - people age 12 and older
Uveitis - people age 2 and older

How Humira (adalimumab) works

Humira (adalimumab) is a biologic disease-modifying antirheumatic drug (DMARD). It blocks tumor necrosis factor (TNF), which is a protein in your body that plays a role in inflammation. By blocking TNF, Humira (adalimumab) lowers inflammation to relieve symptoms in the joints, skin, and gut.

Drug Facts

Common BrandsHumira

Drug ClassBiologic DMARD

Controlled Substance ClassificationNot a controlled medication

Generic StatusNo lower-cost generic available

AvailabilityPrescription only

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Avg retail price

$1732.96(save 24.94%)

GoodRx discount

$1300.76

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What are the side effects of Humira (adalimumab)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Injection-site reaction (20%)
Upper respiratory tract infection (17%)
Headache (12%)
Rash (12%)
Sinus inflammation (11%)
Accidental injury (10%)
Nausea (9%)
Urinary tract infection (UTI) or bladder infection (8%)

Other Side Effects

High cholesterol
High blood pressure
Back pain
Stomach pain
Hair loss
Blood in the urine
Flu-like symptoms

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.

Serious infection: fever, cough, weight loss, muscle aches, dark urine, chills, vomiting
Low blood cell counts: fever that doesn't go away, easy bruising or bleeding, pale skin
Severe allergic reaction: rash, trouble breathing, swelling of your face, eyes, lips, or mouth, hives
Heart failure: shortness of breath, swelling in the legs, ankles, or feet, irregular heartbeat, tiredness, sudden weight gain
Liver problems: feeling tired, vomiting, yellow skin or whites of the eyes, stomach pain

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Body aches or pain

cough

ear congestion

gas with stomach pain

hoarseness

lightheadedness

loss of voice

lower back or side pain

muscle aches and pains

pain or tenderness around the eyes or cheekbones

rapid and sometimes shallow breathing

shivering

stomach fullness

stuffy nose

sunken eyes

thirst

trouble sleeping

warmth on the skin

wrinkled skin

Less common

Abnormal vaginal bleeding or discharge

agitation

arm, back, or jaw pain

black, tarry stools

bleeding from the gums or nose

blindness

bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the stool or change in bowel habits

bloody or cloudy urine

blurred vision

broken bones

change in size, shape, or color of an existing mole

change in skin color

chest pain, tightness, or heaviness

chills

clear or bloody discharge from the nipple

cold hands and feet

confusion

constipation

cough

coughing or spitting up blood

decreased urination

decreased vision

depression

difficulty with breathing

difficulty, burning, or painful urination

dimpling of the breast skin

dizziness

drowsiness

eye pain

fainting

fast, slow, or irregular heartbeat

fever

forgetfulness

frequent urge to urinate

general feeling of illness

hair loss

headache

hives, itching, skin rash

increased thirst

inverted nipple

irregular breathing

irregular pulse

irritability

light colored stools

loss of appetite

lump in the breast or under your arm

lump or swelling in the stomach

mole that leaks fluid or bleeds

muscle cramps or spasms

nausea

new mole

night sweats

no blood pressure or pulse

noisy breathing

numbness or tingling in your arms, legs, or face

pain, redness, or swelling in the arms or legs without any injury present

pale skin

persistent non-healing sore on your skin

pink growth

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

raised, firm, or bright red patch

redness or swelling of the breast

seeing or hearing things that are not there

seizures

sharp back pain just below your ribs

shiny bump on your skin

slurred speech or problems with swallowing

sneezing

sore on the skin of the breast that does not heal

sore throat

sores, ulcers, or white spots on the lips or mouth

spitting up blood

stiff neck

stomach pain

stopping of the heart

sudden high fever or low grade fever for months

sweating

swelling of the face, fingers, feet, or lower legs

swollen glands

swollen neck veins

tiredness

trouble breathing

trouble thinking

unconsciousness

unexplained bruising or bleeding

unpleasant breath odor

unusual tiredness or weakness

unusual weight gain or loss

visual disturbances

vomiting

vomiting of blood or material that looks like coffee grounds

yellow skin or eyes

Incidence not known

Blistering, peeling, or loosening of the skin

diarrhea

inability to move the arms and legs

joint or muscle pain

pinpoint red spots on the skin

red skin lesions, often with a purple center

red, irritated eyes

red, scaling, or crusted skin

sudden numbness and weakness in the arms and legs

unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Bladder pain

bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

pounding in the ears

Less common

Abnormal healing

decrease in height

difficulty with moving

difficulty with walking

dry mouth

heartburn

indigestion

loss of hearing

loss of strength or energy

menstrual changes

muscle or joint stiffness, tightness, or rigidity

muscle pain or weakness

pain in the back, ribs, arms, or legs

shakiness in the legs, arms, hands, and feet

swelling or redness in the joints

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Pros and cons of Humira (adalimumab)

Pros

Can be used for many autoimmune conditions

Available as a ready-to-use pen that makes it easier to self-inject at home

Can be used in young children (as young as 2 years old for some conditions)

Only needs to be injected a couple times a month

Can be left at room temperature for up to 14 days if needed

Cons

Raises the risk of serious infections

Might raise the risk of lymphoma and skin cancers

Might be difficult to inject for some people

Can't receive any live vaccines while taking the medication

Contains rubber or latex, which can cause a reaction for those with an allergy

Pharmacist tips for Humira (adalimumab)

You should receive injection training from your healthcare provider or care team. If you haven't, contact the clinic or call 1-800-4HUMIRA. Don't try to give yourself a Humira (adalimumab) injection until you're comfortable doing it safely and properly. Other resources that might help include the Instructions for Use and videos from the manufacturer.

Store Humira (adalimumab) in the refrigerator. Keep it in its original container to protect it from light. Never freeze it because this could damage the medication.

If you're traveling or don't have access to a refrigerator, Humira (adalimumab) can be left at room temperature for 14 days. After 14 days, it should be thrown away.

Once you're ready for your injection, take Humira (adalimumab) out of the refrigerator and let it warm up to room temperature for about 15 to 30 minutes. This will help prevent discomfort and pain with the injection. Don't try to warm it up by putting it in the microwave or in hot water.

Don't use Humira (adalimumab) pens or syringes if you accidentally drop them. Some of the products are made of glass and can break. If this happens, call your pharmacist.

Humira (adalimumab) can rarely cause a condition called lupus-like syndrome. Contact your provider if you experience rash, easy bruising or bleeding, or feel more tired than usual.

After you inject Humira (adalimumab), throw away used needles, syringes, and pens in a sharps container. You can buy an FDA-cleared container or use a heavy-duty plastic container you have at home. Old laundry detergent containers are a great option. Check your local laws and guidelines for disposal directions once your container is almost full.

Frequently asked questions about Humira (adalimumab)

What exactly does Humira do?

Humira works by targeting and blocking a protein in the body called tumor necrosis factor (TNF). In … Learn more

What is the downside to Humira?

Humira works by intentionally lowering your immune response. At the same time, your immune system al… Learn more

What is Humira and what are the side effects?

Humira (adalimumab) is a biologic medication used for many autoimmune disorders, including rheumatoi… Learn more

What is the most common side effect of Humira?

The most common Humira side effect is injection site reactions. Respiratory infections, headaches, a… Learn more

What is the long-term risk of Humira?

Several medications have potential long-term risks, including Humira. For instance, it's been rarely… Learn more

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What are the risks and warnings for Humira (adalimumab)?

Humira (adalimumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Serious infections

Risk factors: Taking other medications that weaken the immune system | Older adults | Active, long-term, or an infection that keeps coming back | Traveling to high risk areas | Having other conditions that raise the risk of infection

Humira (adalimumab) can raise your risk of serious or life-threatening infections. Serious infections are more common in older adults, people taking other medications that can weaken the immune system (e.g., methotrexate, Orencia (abatacept), Kineret (anakinra), corticosteroids), and people with other health conditions. Make sure your provider knows your past medical history before starting Humira (adalimumab), especially if you've ever had tuberculosis or hepatitis B. They'll review your risk before starting the medication. If you develop a serious infection while taking Humira (adalimumab), you might have to stop the medication in order to give your immune system a chance to fight the infection.

Cancers

Risk factors: Taking other medications that weaken the immune system | History of cancer | People with chronic obstructive pulmonary disease (COPD) with a history of smoking

In clinical trials, there was a greater number of cancers in people taking Humira (adalimumab) when compared to people not taking the medication. Certain cancers like lymphoma, leukemia, and skin cancers were the most commonly reported types in people who used Humira (adalimumab). Your provider will determine your risk before starting Humira (adalimumab) and monitor you while you're taking the medication. Speak to your provider if you have any concerns.

Severe allergic reactions

Rarely, Humira (adalimumab) can cause life-threatening allergic reactions like anaphylaxis (closing of the throat). If you experience rash, itching, trouble breathing, or swelling in your face or throat, get medical help right away.

Nervous system effects

Risk factors: Currently have or recently developed a nervous system condition

Although rare, Humira (adalimumab) can cause you to develop conditions that affect your nervous system, such as multiple sclerosis (MS) and Guillain-Barré syndrome. If you currently have nerve problems, let your provider know. They'll want to monitor you closely while you're taking Humira (adalimumab), since it can make them worse. Let your provider know right away if you notice numbness or tingling, weakness in your arms or legs, vision problems, or dizziness.

Low blood cell counts

It's rare, but there have been reports of people having low blood cells while taking Humira (adalimumab). This can lower your body's ability to fight infections and put you at risk for bleeding. Contact your provider if you develop a fever that doesn't go away, easy bruising, pale skin, or bleeding.

Heart failure

People taking Humira (adalimumab) have had new or worsening cases of heart failure. Speak with your provider if you currently have heart failure. They'll weigh the benefits and risks to determine if Humira (adalimumab) is right for you. Also let your provider know if you start to have shortness of breath, swelling in the legs, ankles, or feet, irregular heartbeat, or tiredness or weakness, as these can be signs of heart failure.

Live vaccines

It's fine to get some vaccines while you're taking Humira (adalimumab), but avoid getting live vaccines (e.g., MMR II (measles, mumps, and rubella vaccine)). This is because it isn't known if they're safe or work well while you're taking Humira (adalimumab). It's recommended that children get all of their appropriate shots before starting Humira (adalimumab). Ask your provider or pharmacist to make sure that you can get the appropriate vaccines while taking this medication.

Humira (adalimumab) dosage forms

Typical dosing for Humira (adalimumab)

Adults

Rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: The typical dose is 40 mg injected under the skin every other week.
Crohn's disease and ulcerative colitis: The typical dose is 160 mg injected under the skin on Day 1, followed by 80 mg on Day 15, then 40 mg every other week starting Day 29.
Plaque psoriasis and uveitis: The typical dose is 80 mg injected under the skin on Day 1, followed by 40 mg every other week starting 1 week after the first dose.
Hidradenitis suppurativa: The typical dose is 160 mg injected under the skin on Day 1, followed by 80 mg on Day 15, then 40 mg every week OR 80 mg every other week starting Day 29.

Children

Juvenile idiopathic arthritis and uveitis: The dose is based on your child's body weight. Typically it will be injected under the skin every other week.
Crohn's disease, ulcerative colitis, and hidradenitis suppurativa: The dose is based on your child's body weight and the condition being treated. Typically it injected under the skin either every week or every other week.

Interactions between Humira (adalimumab) and other drugs

Humira (adalimumab) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Humira (adalimumab). Please note that only the generic name of each medication is listed below.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.