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Humira vs. Taclonex

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Humira (adalimumab) and Taclonex (betamethasone/calcipotriene) are both prescription medications, but they treat different conditions and work in different ways. Humira is an injectable biologic Disease Modifying Anti-Rheumatic Drug (DMARD) used for various autoimmune conditions like rheumatoid arthritis, Crohn's disease, and plaque psoriasis. It works by blocking tumor necrosis factor (TNF), a protein involved in inflammation. Taclonex, on the other hand, is a topical medication used specifically for plaque psoriasis. It combines calcipotriene, a form of vitamin D that slows skin cell growth, and betamethasone, a corticosteroid that reduces inflammation. Humira is administered subcutaneously every other week, while Taclonex is applied to the skin once daily. Humira can be used in children as young as two years old for some conditions, whereas Taclonex is not recommended for children under 12. Additionally, Humira has a higher risk of serious infections and certain cancers, while Taclonex can cause skin irritation and sensitivity to sunlight.

Humira

(adalimumab)

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Taclonex

(calcipotriene / betamethasone)

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Summary for Humira

Prescription only

Humira (adalimumab) is an injection used to treat many different autoimmune conditions like rheumatoid arthritis, Crohn's disease, ulcerative colitis, and plaque psoriasis. As a TNF blocker, the medication works by blocking a protein that causes inflammation in your body. It's given as a shot under the skin once every 1 to 2 weeks, depending on your condition. Humira (adalimumab) doesn't have a true generic, but there are several similar versions called biosimilars. Common side effects include infections, injection site reactions, and headache.

Indications for Humira

Pros and Cons for Humira

Pros

  • Can be used for many autoimmune conditions
  • Available as a ready-to-use pen that makes it easier to self-inject at home
  • Can be used in young children (as young as 2 years old for some conditions)
  • Only needs to be injected a couple times a month
  • Can be left at room temperature for up to 14 days if needed

Cons

  • Raises the risk of serious infections
  • Can take a few weeks or longer to work
  • Might be difficult to inject for some people
  • Can't receive any live vaccines while taking the medication
  • Might contain rubber or latex, which can cause a reaction for those with an allergy

Common Side Effects for Humira

  • Injection-site reaction (20%)
  • Upper respiratory tract infection (17%)
  • Headache (12%)
  • Rash (12%)
  • Sinus inflammation (11%)
  • Accidental injury (10%)
  • Nausea (9%)
  • Urinary tract infection (UTI) or bladder infection (8%)

Note: The side effects listed above were reported by adults with rheumatoid arthritis and are similar to those seen in people using Humira (adalimumab) for other conditions.

Warnings for Humira

  • Serious infections
  • Cancers
  • Severe allergic reactions
  • Nervous system effects
  • Low blood cell counts
  • Heart failure
  • Lupus-like syndrome
  • Live vaccines

Summary for Taclonex

Prescription only

Taclonex (calcipotriene / betamethasone) is a combination medication used to treat plaque psoriasis in adults and children ages 12 years and older. It contains betamethasone (a topical corticosteroid) and calcipotriene (a form of vitamin D). Taclonex (calcipotriene / betamethasone) is available as brand name and generic ointment and topical suspension. The suspension can be applied to the scalp and body once daily for up to 8 weeks, while the ointment can be applied once daily for 4 weeks. Side effects can include itching and a burning sensation on the skin.

Indications for Taclonex

Pros and Cons for Taclonex

Pros

  • Only need to apply it once a day
  • Combines two medications for convenience
  • Comes in an ointment and suspension
  • Available in lower-cost generic versions

Cons

  • Might need to use for many weeks
  • Can cause skin irritation
  • Can't be used in children under 12 years of age
  • Not available over the counter

Common Side Effects for Taclonex

Ointment

  • Itching (3%)
  • Headache (3%)
  • Runny nose, sore throat (2%)

Suspension

  • Itching (4%)
  • Psoriasis (2%)
  • Skin redness (2%)

Warnings for Taclonex

  • High calcium levels
  • Changes in stress hormone levels
  • Allergic skin reaction
  • Cataracts and glaucoma
  • Sun sensitivity

Prices with our coupons for Humira vs. Taclonex

Price Card Drug Icon
Humira1 carton / 2 pens of 40mg/0.4ml
$6,380.16-
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Betamethasone/Calcipotriene1 tube / 60g of 0.005%/0.064%
$77.29$513.98
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