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Compare Entyvio vs. Humira

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Vedolizumab (Entyvio) and adalimumab (Humira) are both Disease-Modifying Antirheumatic Drugs (DMARDs) used to treat autoimmune conditions like Crohn's disease (CD) and ulcerative colitis (UC). However, they belong to different medication classes. Vedolizumab is an integrin antagonist, while adalimumab blocks tumor necrosis factor (TNF). Vedolizumab is available as an intravenous infusion or a subcutaneous injection, whereas adalimumab is only given as a subcutaneous injection. Vedolizumab is typically administered every 2 months as an infusion or every 2 weeks as an injection for maintenance, while adalimumab is usually given every 2 weeks. Adalimumab is approved for a wider range of conditions, including rheumatoid arthritis and plaque psoriasis, and can be used in children for some conditions. Common side effects of vedolizumab include headache and joint pain, while adalimumab can cause injection-site reactions and upper respiratory infections. Both medications can increase the risk of infections, but adalimumab also carries a risk of certain cancers and heart failure.

Entyvio (vedolizumab)
Humira (adalimumab)
Entyvio (vedolizumab)
Humira (adalimumab)
Summary of Entyvio vs. Humira
Summary for Integrin antagonist
Prescription only
Entyvio, the brand name for vedolizumab, is an injection used to treat ulcerative colitis (UC) and Crohn's disease (CD) in adults. It belongs to a drug class called integrin antagonists that helps lower inflammation in the gut. Entyvio (vedolizumab) is an infusion that's given through the vein by a healthcare professional. After the first 2 doses, it's usually given every 2 months. If it works well, people can switch to injections under the skin every 2 weeks using prefilled syringes or pens. Side effects include headache, mild infections, and joint pain.
Summary for TNF blocker
Prescription only
Humira (adalimumab) is an injection used to treat many different autoimmune conditions like rheumatoid arthritis, Crohn's disease, ulcerative colitis, and plaque psoriasis. As a TNF blocker, the medication works by blocking a protein that causes inflammation in your body. It's given as a shot under the skin once every 1 to 2 weeks, depending on your condition. Humira (adalimumab) doesn't have a true generic, but there are several similar versions called biosimilars. Common side effects include infections, injection site reactions, and headache.
Indications of Entyvio vs. Humira
Indications for

•Moderate-to-severe ulcerative colitis (UC) in adults

•Moderate-to-severe Crohn's disease (CD) in adults

Indications for

•Rheumatoid arthritis (RA) - adults only

•Juvenile idiopathic arthritis (JIA) - people age 2 and older

•Psoriatic arthritis (PsA) - adults only

•Ankylosing spondylitis (AS) - adults only

•Crohn's disease (CD) - people age 6 and older

•Ulcerative colitis (UC) - people age 5 and older

•Plaque psoriasis - adults only

•Hidradenitis suppurativa (HS) - people age 12 and older

•Uveitis - people age 2 and older
Pros and Cons of Entyvio vs. Humira
Pros and Const for Integrin antagonist
Pros

•Have the option for infusions through the vein or injections under the skin after 6 weeks of treatment

•Comes as prefilled syringes and pens for injections under the skin that can be given at home

Cons

•IV infusions can only be given by a healthcare professional at a medical office

•Can raise your risk of serious side effects, like infusion reactions and infections

Pros and Const for TNF blocker
Pros

•Can be used for many autoimmune conditions

•Available as a ready-to-use pen that makes it easier to self-inject at home

•Can be used in young children (as young as 2 years old for some conditions)

•Only needs to be injected a couple times a month

•Can be left at room temperature for up to 14 days if needed

Cons

•Raises the risk of serious infections

•Can take a few weeks or longer to work

•Might be difficult to inject for some people

•Can't receive any live vaccines while taking the medication

•Might contain rubber or latex, which can cause a reaction for those with an allergy
Common Side Effects of Entyvio vs. Humira
Common Side Effects for

•Infection in nose and throat (13%)

•Headache (12%)

•Joint pain (12%)

•Nausea (9%)

•Fever (9%)

•Upper respiratory tract infection (7%)

•Fatigue (6%)

•Cough (5%)

Common Side Effects for

•Injection-site reaction (20%)

•Upper respiratory tract infection (17%)

•Headache (12%)

•Rash (12%)

•Sinus inflammation (11%)

•Accidental injury (10%)

•Nausea (9%)

•Urinary tract infection (UTI) or bladder infection (8%)

Note: The side effects listed above were reported by adults with rheumatoid arthritis and are similar to those seen in people using Humira (adalimumab) for other conditions.
Warnings of Entyvio vs. Humira
Common Side Effects for

•Infusion-related reactions and allergic reactions

•Risk of serious infections

•Risk of brain infection (progressive multifocal leukoencephalopathy)

•Liver problems

Common Side Effects for

•Serious infections

•Cancers

•Severe allergic reactions

•Nervous system effects

•Low blood cell counts

•Heart failure

•Lupus-like syndrome

•Live vaccines
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Key takeaways

Summary of Entyvio vs. Humira

Indications of Entyvio vs. Humira

Pros and Cons of Entyvio vs. Humira

Common Side Effects of Entyvio vs. Humira

Warnings of Entyvio vs. Humira

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