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Compare Entyvio vs. Stelara

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Vedolizumab (Entyvio) and ustekinumab (Stelara) are both Disease-Modifying Antirheumatic Drugs (DMARDs) used to treat autoimmune conditions like Crohn's disease (CD) and ulcerative colitis (UC). However, they belong to different medication classes. Vedolizumab is an integrin antagonist, while ustekinumab is an interleukin antagonist that blocks IL-12 and IL-23 proteins. Vedolizumab is administered either as an intravenous infusion every two months or as a subcutaneous injection every two weeks, whereas ustekinumab is typically gives as a subcutaneous injection every eight to twelve weeks for maintenance, depending on the condition. Both medications come as a subcutaneous injection and an intravenous infusion. Common side effects of vedolizumab include headache and joint pain, while ustekinumab may cause cold symptoms and headaches. Both medications can increase the risk of infections, but ustekinumab also carries a risk of certain cancers and a rare condition called posterior reversible encephalopathy syndrome (PRES). Both are only available as a branded medication.

  • Entyvio (vedolizumab)
    Stelara (ustekinumab)
  • Entyvio (vedolizumab)
    Stelara (ustekinumab)

  • Summary of Entyvio vs. Stelara

    Summary for Integrin antagonist
    Prescription only

    Entyvio, the brand name for vedolizumab, is an injection used to treat ulcerative colitis (UC) and Crohn's disease (CD) in adults. It belongs to a drug class called integrin antagonists that helps lower inflammation in the gut. Entyvio (vedolizumab) is an infusion that's given through the vein by a healthcare professional. After the first 2 doses, it's usually given every 2 months. If it works well, people can switch to injections under the skin every 2 weeks using prefilled syringes or pens. Side effects include headache, mild infections, and joint pain.

    Summary for IL-12 and IL-23 antagonist
    Prescription only

    Stelara (ustekinumab) is an injectable medication used to treat autoimmune conditions like plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. As an interleukin antagonist, it works by blocking certain proteins that cause inflammation in your body, which helps reduce swelling and ease symptoms. You typically get it as an injection under your skin. Common side effects include common cold symptoms, headache, and feeling tired. This medication also has many biosimilars available.

  • Indications of Entyvio vs. Stelara

    Indications for
    •Moderate-to-severe ulcerative colitis (UC) in adults
    •Moderate-to-severe Crohn's disease (CD) in adults
    Indications for
    •Moderate-to-severe plaque psoriasis (Ps) - adults and children 6 years and older
    •Psoriatic arthritis (PsA) - adults and children 6 years and older
    •Moderate-to-severe Crohn's disease (CD) - adults only
    •Moderate-to-severe ulcerative colitis (UC) - adults only

  • Pros and Cons of Entyvio vs. Stelara

    Pros and Const for Integrin antagonist
    Pros
    •Have the option for infusions through the vein or injections under the skin after 6 weeks of treatment
    •Comes as prefilled syringes and pens for injections under the skin that can be given at home
    Cons
    •IV infusions can only be given by a healthcare professional at a medical office
    •Can raise your risk of serious side effects, like infusion reactions and infections
    Pros and Const for IL-12 and IL-23 antagonist
    Pros
    •After the first few doses, only need a shot every 8 to 12 weeks
    •Available as a prefilled syringe or vial
    •Syringes can be stored at room temperature for up to 30 days
    •Approved for children as young as 6 years old
    Cons
    •Can weaken your immune system and raise your risk of infection
    •Potential to cause serious allergic reactions
    •For CD and UC, the first dose must be given as an IV infusion
    •Can't receive live vaccines while taking this medication

  • Common Side Effects of Entyvio vs. Stelara

    Common Side Effects for
    •Infection in nose and throat (13%)
    •Headache (12%)
    •Joint pain (12%)
    •Nausea (9%)
    •Fever (9%)
    •Upper respiratory tract infection (7%)
    •Fatigue (6%)
    •Cough (5%)
    Common Side Effects for

    Plaque psoriasis

    •Common cold symptoms (7-8%)
    •Upper respiratory tract infection (4-5%)
    •Headache (5%)

    Psoriatic arthritis

    •Joint pain (3%)
    •Nausea (3%)

    Crohn's disease

    •Common cold symptoms (11%)
    •Redness at the injection site (5%)
    •Yeast infection (5%)
    •Bronchitis (5%)

    Ulcerative colitis:

    •Common cold symptoms (24%)
    •Headache (10%)
    •Stomach pain (7%)
    •Flu infection (6%)
    •Fever (5%)

  • Warnings of Entyvio vs. Stelara

    Common Side Effects for
    •Infusion-related reactions and allergic reactions
    •Risk of serious infections
    •Risk of brain infection (progressive multifocal leukoencephalopathy)
    •Liver problems
    Common Side Effects for
    •Infections
    •Cancers
    •Severe allergic reaction
    •Brain condition
    •Vaccines
    •Lung problems

  • Prices with our coupons for Entyvio vs. Stelara

    Learn more about Entyvio
    Learn more about Stelara

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