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Compare Tremfya vs. Entyvio

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Tremfya (guselkumab) and Entyvio (vedolizumab) are both monoclonal antibody medications used to treat inflammatory conditions, but they differ in their specific uses and mechanisms. Both medications are used for moderate-to-severe ulcerative colitis and Crohn's disease in adults, but Tremfya is approved for moderate-to-severe plaque psoriasis and active psoriatic arthritis. Tremfya works by blocking interleukin-23 (IL-23) to reduce inflammation, whereas Entyvio targets integrins on immune cells to lower inflammation. Tremfya is administered as a subcutaneous injection every 8 weeks after initial doses, while Entyvio can be given as an intravenous infusion every 2 months or as a subcutaneous injection every 2 weeks. Both Tremfya and Entyvio are only available as brand-name medications. Common side effects of Tremfya include upper respiratory infections and headaches, while Entyvio may cause headaches, joint pain, and infections. Both medications can increase the risk of infections due to their effects on the immune system.

  • Tremfya (guselkumab)
    Entyvio (vedolizumab)
  • Tremfya (guselkumab)
    Entyvio (vedolizumab)

  • Summary of Tremfya vs. Entyvio

    Summary for Interleukin antagonist
    Prescription only

    Tremfya (guselkumab) is an injection for adults with certain inflammatory conditions. It helps treat plaque psoriasis, psoriatic arthritis, ulcerative colitis, and Crohn's disease. Tremfya (guselkumab) is a monoclonal antibody known as an interleukin antagonist. It calms your immune system to lower inflammation. The dosing schedule is every 1 or 2 months, depending on your condition and how far along you are in treatment. Side effects are upper respiratory infections, headache, and injection site reactions. There's also a risk of other infections and liver problems as long-term side effects.

    Summary for Integrin antagonist
    Prescription only

    Entyvio, the brand name for vedolizumab, is an injection used to treat ulcerative colitis (UC) and Crohn's disease (CD) in adults. It belongs to a drug class called integrin antagonists that helps lower inflammation in the gut. Entyvio (vedolizumab) is an infusion that's given through the vein by a healthcare professional. After the first 2 doses, it's usually given every 2 months. If it works well, people can switch to injections under the skin every 2 weeks using prefilled syringes or pens. Side effects include headache, mild infections, and joint pain.

  • Indications of Tremfya vs. Entyvio

    Indications for
    •Moderate-to-severe plaque psoriasis
    •Active psoriatic arthritis
    •Moderate-to-severe ulcerative colitis (UC)
    •Moderate-to-severe Crohn's disease (CD)
    Indications for
    •Moderate-to-severe ulcerative colitis (UC) in adults
    •Moderate-to-severe Crohn's disease (CD) in adults

  • Pros and Cons of Tremfya vs. Entyvio

    Pros and Const for Interleukin antagonist
    Pros
    •An option for adults with plaque psoriasis who've already tried topical treatment
    •Given every 1 or 2 months (depending on your condition and treatment plan)
    •Few side effects
    •Can give yourself injections under the skin at home after you get trained
    Cons
    •Given as an injection under the skin or injection through the vein
    •Raises the risk of infections
    •Can cause some injection site reactions
    •Can take several months to see the benefits of the medication
    Pros and Const for Integrin antagonist
    Pros
    •Have the option for infusions through the vein or injections under the skin after 6 weeks of treatment
    •Comes as prefilled syringes and pens for injections under the skin that can be given at home
    Cons
    •IV infusions can only be given by a healthcare professional at a medical office
    •Can raise your risk of serious side effects, like infusion reactions and infections

  • Common Side Effects of Tremfya vs. Entyvio

    Common Side Effects for
    •Upper respiratory infections (14%)
    •Headache (5%)
    •Injection site reactions (5%)
    •Joint pain (3%)
    Common Side Effects for
    •Infection in nose and throat (13%)
    •Headache (12%)
    •Joint pain (12%)
    •Nausea (9%)
    •Fever (9%)
    •Upper respiratory tract infection (7%)
    •Fatigue (6%)
    •Cough (5%)

  • Warnings of Tremfya vs. Entyvio

    Common Side Effects for
    •Serious allergic reactions
    •Risk of infections
    •Liver damage
    •Interaction with vaccines
    Common Side Effects for
    •Infusion-related reactions and allergic reactions
    •Risk of serious infections
    •Risk of brain infection (progressive multifocal leukoencephalopathy)
    •Liver problems

  • Prices with our coupons for Tremfya vs. Entyvio

    Learn more about Tremfya
    Learn more about Entyvio

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