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Compare Duobrii vs. Skyrizi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Duobrii (halobetasol/tazarotene) and Skyrizi (risankizumab) are both used to treat plaque psoriasis, but they have some key differences. Duobrii is a topical lotion that combines a corticosteroid and a retinoid, while Skyrizi is an injectable interleukin antagonist. Duobrii is applied once daily directly to the skin, whereas Skyrizi is injected under the skin every 2 to 3 months after initial doses. Duobrii can cause skin irritation and sun sensitivity, and it is not recommended for long-term use due to potential hormone changes. On the other hand, Skyrizi can increase the risk of infections and may cause joint pain and headaches. Skyrizi is also used to treat psoriatic arthritis and Crohn's disease, while Duobrii is specifically for plaque psoriasis. Both Duobrii and Skyrizi are only available as a brand-name medication, making them potentially more expensive. Duobrii can be self-applied, whereas Skyrizi is a biologic medication that can be self-administered at home after proper training.

  • Duobrii (halobetasol / tazarotene)
    Skyrizi (risankizumab)
  • Duobrii (halobetasol / tazarotene)
    Skyrizi (risankizumab)

  • Summary of Duobrii vs. Skyrizi

    Summary for Corticosteroid / Retinoid
    Prescription only

    Duobrii is a combination medication that contains halobetasol (a corticosteroid) and tazarotene (a retinoid). It's a prescription topical lotion that's FDA-approved to treat plaque psoriasis in adults. The directions for using the medication are to apply a thin amount over the affected area(s) of skin once per day. But avoid putting on the face, groin, and underarms. Side effects aren't common, but can include skin rash and pain at the site of application. Duobrii is brand name only and not available as a generic.

    Summary for Interleukin antagonist
    Prescription only

    Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

  • Indications of Duobrii vs. Skyrizi

    Indications for
    •Plaque psoriasis in adults
    Indications for
    •Moderate-to-severe plaque psoriasis in adults
    •Psoriatic arthritis in adults
    •Moderate-to-severe Crohn's disease in adults
    •Moderate-to-severe ulcerative colitis in adults

  • Pros and Cons of Duobrii vs. Skyrizi

    Pros and Const for Corticosteroid / Retinoid
    Pros
    •Applied once daily
    •Combines two medications into one lotion
    •Might see some improvements in as early as 2 weeks
    Cons
    •For adults only; not studied in children
    •Not safe to use while pregnant or breastfeeding
    •Available as a brand-name product only
    Pros and Const for Interleukin antagonist
    Pros
    •Given every 2 or 3 months after a couple of starter doses (depends on your condition)
    •Can give injections under the skin at home after you get trained
    Cons
    •Must be given as an injection
    •Not approved for children

  • Common Side Effects of Duobrii vs. Skyrizi

    Common Side Effects for
    •Skin rash (7%)
    •Pain where the medication was applied (3%)
    Common Side Effects for
    •Upper respiratory infections (13%)
    •Headache (4%)
    •Tiredness (3%)

  • Warnings of Duobrii vs. Skyrizi

    Common Side Effects for
    •Harm to unborn babies
    •Altered stress hormone levels
    •Skin reactions and skin infections
    •Sun sensitivity and risk of sunburn
    •Cataracts and glaucoma
    Common Side Effects for
    •Allergic reaction
    •Risk of infection
    •Rare case of liver injury
    •Caution when getting vaccines

  • Prices with our coupons for Duobrii vs. Skyrizi

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    Learn more about Skyrizi

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