Compare
Duobrii vs. Skyrizi

Duobrii is a combination medication that contains halobetasol (a corticosteroid) and tazarotene (a retinoid). It's a prescription topical lotion that's FDA-approved to treat plaque psoriasis in adults. The directions for using the medication are to apply a thin amount over the affected area(s) of skin once per day. But avoid putting on the face, groin, and underarms. Side effects aren't common, but can include skin rash and pain at the site of application. Duobrii is brand name only and not available as a generic.

• Plaque psoriasis in adults

• Skin rash (7%)
• Pain where the medication was applied (3%)

• Harm to unborn babies
• Altered stress hormone levels
• Skin reactions and skin infections
• Sun sensitivity and risk of sunburn
• Cataracts and glaucoma

Skyrizi (risankizumab or risankizumab-rzaa) is an injectable medication for many inflammatory conditions. It treats plaque psoriasis in adults and children ages 6 years and up. It can also treat psoriatic arthritis, Crohn's disease, and ulcerative colitis in adults. This medication works as an interleukin antagonist to help lower inflammation. After a few starter doses, it's given every 2 or 3 months, depending on the condition being treated. Side effects include a higher risk of infection.

• Moderate-to-severe plaque psoriasis in adults and children ages 6 years and older
• Psoriatic arthritis in adults
• Moderate-to-severe Crohn's disease in adults
• Moderate-to-severe ulcerative colitis in adults

• Upper respiratory infections (13%)
• Headache (4%)
• Tiredness (3%)

• Allergic reaction
• Risk of infection
• Rare case of liver injury
• Caution when getting vaccines