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Compare Duobrii vs. Temovate

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Duobrii (halobetasol/tazarotene) and clobetasol (Clobex, Impoyz) are both topical treatments for skin conditions, but they have some key differences. Duobrii is a combination of a corticosteroid (halobetasol) and a retinoid (tazarotene), specifically designed to treat plaque psoriasis in adults. It is only available as a brand-name lotion and can be expensive. Clobetasol, on the other hand, is a super potent corticosteroid available in various forms, including cream, shampoo, lotion, and spray. It treats a wider range of skin issues, such as moderate to severe psoriasis and eczema, and is available in generic form, making it more affordable. Duobrii is used once daily, while Clobetasol is typically applied twice daily but for no more than two weeks at a time due to the risk of serious side effects. Both medications can cause skin irritation and should not be used on sensitive areas like the face, groin, or armpits. However, Duobrii also increases sun sensitivity and is not recommended for long-term use, especially during pregnancy. Clobetasol, while also not recommended for long-term use, has a broader range of formulations and is generally more versatile in treating different skin conditions.

  • Duobrii (halobetasol / tazarotene)
    Clobetasol
  • Duobrii (halobetasol / tazarotene)
    Clobetasol

  • Summary of Duobrii vs. Temovate

    Summary for Corticosteroid / Retinoid
    Prescription only

    Duobrii is a combination medication that contains halobetasol (a corticosteroid) and tazarotene (a retinoid). It's a prescription topical lotion that's FDA-approved to treat plaque psoriasis in adults. The directions for using the medication are to apply a thin amount over the affected area(s) of skin once per day. But avoid putting on the face, groin, and underarms. Side effects aren't common, but can include skin rash and pain at the site of application. Duobrii is brand name only and not available as a generic.

    Summary for Corticosteroid
    Prescription only

    Clobetasol is a super potent (very strong) steroid medication that's applied to the skin. It's used to relieve skin inflammation and irritation caused by moderate to severe skin problems, such as psoriasis. Clobetasol is available in many different formulations, including cream, shampoo, lotion, and spray. Most formulations of clobetasol aren't recommended to be used for more than 2 weeks at a time since it can cause serious side effects. In general, clobetasol is for adults only, but some formulations (e.g., solution and foam) can be used by children as young as 12 years old.

  • Indications of Duobrii vs. Temovate

    Indications for
    •Plaque psoriasis in adults
    Indications for
    •Treatment of skin rashes and itchy skin - all topical forms except shampoo
    •Treatment of moderate to severe scalp psoriasis - foam and shampoo only
    •Treatment of plaque psoriasis not on the scalp - all topical forms except shampoo

  • Pros and Cons of Duobrii vs. Temovate

    Pros and Const for Corticosteroid / Retinoid
    Pros
    •Applied once daily
    •Combines two medications into one lotion
    •Might see some improvements in as early as 2 weeks
    Cons
    •For adults only; not studied in children
    •Not safe to use while pregnant or breastfeeding
    •Available as a brand-name product only
    Pros and Const for Corticosteroid
    Pros
    •Available as a lower-cost, generic medication
    •One of the most potent (high strength) topical steroids
    •Many formulations to choose from, such as ointment, cream, and spray
    •Works well to manage psoriasis symptoms
    Cons
    •For short-term use only, otherwise it might cause skin thinning and high blood sugar
    •Not safe to use on the face, armpits, or groin
    •Certain products aren't safe for children under 12 years old (shampoo, lotion, and spray can only be used by adults)
    •Unknown if safe in pregnant or breastfeeding females

  • Common Side Effects of Duobrii vs. Temovate

    Common Side Effects for
    •Skin rash (7%)
    •Pain where the medication was applied (3%)
    Common Side Effects for
    •Burning
    •Stinging
    •Skin irritation
    •Itching

  • Warnings of Duobrii vs. Temovate

    Common Side Effects for
    •Harm to unborn babies
    •Altered stress hormone levels
    •Skin reactions and skin infections
    •Sun sensitivity and risk of sunburn
    •Cataracts and glaucoma
    Common Side Effects for
    •Changes in hormone levels
    •Risk of high blood sugar
    •New or worsened skin infection
    •Skin problems

  • Prices with our coupons for Duobrii vs. Temovate

    Learn more about Duobrii
    Learn more about Clobetasol

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