Key takeaways
Halobetasol-tazarotene topical (Duobrii) and halobetasol topical (Bryhali, Lexette, Ultravate) are both used to treat plaque psoriasis, but they belong to different medication classes. Duobrii is a combination of a corticosteroid (halobetasol) and a retinoid (tazarotene), while halobetasol topical is solely a corticosteroid. Duobrii is applied once daily and is only available as a brand-name lotion, whereas halobetasol topical comes in various forms, including creams, ointments, lotions, and foams, and is available as a lower-cost generic. Duobrii is specifically for adults, while some forms of halobetasol can be used by individuals aged 12 and older. Side effects of Duobrii may include skin rash and pain at the application site, while halobetasol may cause burning and stinging sensations on the skin. Both medications can cause skin thinning and should not be used on the face, groin, or underarms. Additionally, Duobrii is not safe for use during pregnancy due to the presence of tazarotene, which can harm an unborn baby.
