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Compare Skyrizi vs. Simponi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Skyrizi (risankizumab) and Simponi (golimumab) are both injectable medications used to treat autoimmune conditions, but they have some key differences. Skyrizi is an interleukin antagonist that targets IL-23 to reduce inflammation, while Simponi is a monoclonal antibody that blocks TNF to achieve a similiar effect. Skyrizi is used for plaque psoriasis, psoriatic arthritis, and Crohn's disease, whereas Simponi treats rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, and ulcerative colitis. Skyrizi is typically administered every 2 to 3 months after initial doses, while Simponi is usually given once a month after starter doses. Both medications can be self-injected under the skin at home after training. Simponi also comes in an intravenous form called Simponi Aria, which can only be administered by a healthcare professional. Both medications can increase the risk of infections, but Simponi also has warnings for potential cancer risks and heart failure. Skyrizi is available as a prefilled syringe, pen, and on-body injector. Simponi only comes in prefilled syringe and autoinjector forms.

  • Skyrizi (risankizumab)
    Simponi (golimumab)
  • Skyrizi (risankizumab)
    Simponi (golimumab)

  • Summary of Skyrizi vs. Simponi

    Summary for Interleukin antagonist
    Prescription only

    Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

    Summary for TNF blocker
    Prescription only

    Simponi (golimumab) is a tumor necrosis factor (TNF) blocker (or inhibitor). It's used to treat many types of inflammatory conditions in adults, such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), and ulcerative colitis (UC). Simponi (golimumab) is given as an injection under the skin, typically once per month. Side effects of this medication include upper respiratory tract infections, injection-site reactions, and high blood pressure.

  • Indications of Skyrizi vs. Simponi

    Indications for
    •Moderate-to-severe plaque psoriasis in adults
    •Psoriatic arthritis in adults
    •Moderate-to-severe Crohn's disease in adults
    •Moderate-to-severe ulcerative colitis in adults
    Indications for
    •Moderate-to-severe rheumatoid arthritis (RA) (in combination with methotrexate (Trexall))
    •Moderate-to-severe psoriatic arthritis (PsA) (alone or in combination with methotrexate (Trexall))
    •Ankylosing spondylitis (AS)
    •Moderate-to-severe ulcerative colitis (UC) when other treatment options haven't worked well

  • Pros and Cons of Skyrizi vs. Simponi

    Pros and Const for Interleukin antagonist
    Pros
    •Given every 2 or 3 months after a couple of starter doses (depends on your condition)
    •Can give injections under the skin at home after you get trained
    Cons
    •Must be given as an injection
    •Not approved for children
    Pros and Const for TNF blocker
    Pros
    •Can be injected at home (after training from the prescriber)
    •Available in a prefilled syringe or autoinjector
    •Can be stored at room temperature for up to 30 days
    •Injected monthly for most conditions
    Cons
    •Only approved for adults
    •Not available as a generic
    •Raises the risk of serious infections
    •Given as an injection

  • Common Side Effects of Skyrizi vs. Simponi

    Common Side Effects for
    •Upper respiratory infections (13%)
    •Headache (4%)
    •Tiredness (3%)
    Common Side Effects for
    •Upper respiratory tract infection (16%)
    •Injection site reactions, including pain and bruising (6%)
    •Viral infections (5%)
    •Higher liver enzymes (up to 4%)
    •High blood pressure (3%)

    Note: Side effects were reported by people who also took other medications (including methotrexate or corticosteroids) at the same time.

  • Warnings of Skyrizi vs. Simponi

    Common Side Effects for
    •Allergic reaction
    •Risk of infection
    •Rare case of liver injury
    •Caution when getting vaccines
    Common Side Effects for
    •Serious infections
    •Risk of cancer
    •Heart failure
    •Nervous system problems
    •Lupus-like syndrome
    •Lower blood cell counts
    •Serious medication interactions
    •Allergic reactions

  • Prices with our coupons for Skyrizi vs. Simponi

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