Skyrizi

For treating plaque psoriasis and psoriatic arthritis: You can give yourself injections of Skyrizi (risankizumab) at home once you get trained by your provider. You'll use either the Skyrizi prefilled syringe or pen.

For treating Crohn's disease: Your provider will give your first 3 doses of Skyrizi (risankizumab) as an infusion through the vein. Be sure to schedule appointments for your infusions; each infusion takes at least 1 hour. After your starter doses, your injections will be given under the skin, and your provider might let you use the medication at home after you get trained. You'll use the Skyrizi On-Body Injector and prefilled cartridges at home.

Before you get any vaccines, tell your provider or pharmacist that you're taking Skyrizi (risankizumab). Your providers can make sure the vaccines are safe for you to get. It's not known whether the medication affects how your body responds to vaccines.

Your healthcare team will train you on how to use Skyrizi (risankizumab) at home. Make sure you know how to safely and properly give yourself injections. As a refresher, be sure to read the instructions for the Skyrizi prefilled syringe or pen or the On-Body Injector. Ask your providers if you have any questions on how to use Skyrizi (risankizumab).

Keep Skyrizi (risankizumab) in the original carton to protect it from light and place it in the refrigerator.

When you're ready for your dose, take the Skyrizi (risankizumab) carton out of the refrigerator (without taking out the pen, syringe, cartridge, or On-Body Injector from the carton). Lay it on a flat surface to warm up; this should take about 15 to 90 minutes, depending on the device you're using. Don't try to warm up the medication any other way.

Skyrizi (risankizumab) is injected under the skin at the front of your thighs or stomach (at least 2 inches from your belly button). For the Skyrizi prefilled pen or syringe, you can also ask someone to help inject the medication under the skin at the back of your upper arms. Never inject it into your muscle or vein.

Skyrizi prefilled pen: Your injection is complete when the pen makes a second "click" or when the yellow indicator fills the inspection window. An injection can take up to 15 seconds.

Skyrizi prefilled syringe: The prefilled syringes come in two strengths (150 mg/mL and 75 mg/0.83 mL). If you're using the 75 mg/0.83 mL strength, you'll need two 75 mg injections, one after the other, to make your 150 mg dose. Use a different area of skin for each injection. Each injection is complete when you see that the syringe is empty, the plunger rod is pushed all the way in, and the whole needle is covered by the needle guard.

Skyrizi On-Body Injector: It can take up to 5 minutes to complete a full injection, and the On-Body Injector will stop by itself. You'll know when your injection is done when you hear beeps and when the status light becomes solid green (not flashing).

After your injection, place your Skyrizi device in a sharps container or a heavy-duty plastic container (e.g., empty milk carton, laundry detergent bottle) to lower the risk of needle-stick injuries. Don't throw away syringes, needles, or On-Body Injectors into your trash can. Visit the FDA's website for guidance on how to safely throw away your sharps container in your specific state.