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Compare Cosentyx vs. Tremfya

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Secukinumab (Cosentyx) and guselkumab (Tremfya) are both medications used to treat plaque psoriasis, psoriatic arthritis, and other inflammatory conditions, but they belong to different medication classes. Secukinumab is an interleukin 17 (IL-17) inhibitor, while guselkumab is a monoclonal antibody that targets interleukin-23 (IL-23). Secukinumab is also approved for other conditions like ankylosing spondylitis and hidradenitis suppurativa, whereas guselkumab is approved for ulcerative colitis and Crohn's disease. Secukinumab is typically injected under the skin monthly after initial weekly doses, and it can also be given as an infusion for certain conditions. Guselkumab is injected under the skin every 8 weeks after the first two doses. Secukinumab is available in prefilled syringes or pens, while guselkumab is available as a prefilled syringe, prefilled pen, or a patient-controlled injector. Common side effects of secukinumab include the common cold and diarrhea, while guselkumab can cause upper respiratory infections and headaches. Both medications can also increase the risk of infections because of their effects on the immune system.

Cosentyx (secukinumab)
Tremfya (guselkumab)
Cosentyx (secukinumab)
Tremfya (guselkumab)
Summary of Cosentyx vs. Tremfya
Summary for Interleukin 17 (IL-17) antagonist
Prescription only
Cosentyx (secukinumab) is an injectable medication that helps treat many inflammatory conditions. This includes psoriatic arthritis (PsA) and hidradenitis suppurativa (HS), among others. The medication works as an interleukin 17 (IL-17) antagonist to lower inflammation in the body. It's usually injected under the skin once a month. You use the prefilled syringes, Sensoready Pens, or UnoReady Pens to inject. For some conditions, it can also be given as an infusion into the vein at a clinic. The dosing depends on your age, health condition, and treatment plan. Side effects can include upper respiratory tract infections and upset stomach. Cosentyx (secukinumab) is a brand-name medication.
Summary for Interleukin antagonist
Prescription only
Tremfya (guselkumab) is an injection for adults with certain inflammatory conditions. It helps treat plaque psoriasis, psoriatic arthritis, ulcerative colitis, and Crohn's disease. Tremfya (guselkumab) is a monoclonal antibody known as an interleukin antagonist. It calms your immune system to lower inflammation. The dosing schedule is every 1 or 2 months, depending on your condition and how far along you are in treatment. Side effects are upper respiratory infections, headache, and injection site reactions. There's also a risk of other infections and liver problems as long-term side effects.
Indications of Cosentyx vs. Tremfya
Indications for

•Plaque psoriasis (PsO) in people 6 years and older

•Psoriatic arthritis (PsA) in people 2 years and older

•Ankylosing spondylitis (AS) in adults

•Non-radiographic axial spondyloarthritis (nr-axSpA) in adults

•Moderate-to-severe hidradenitis suppurativa (HS) in adults

•Enthesitis-related arthritis in children 4 years and older

Indications for

•Moderate-to-severe plaque psoriasis

•Active psoriatic arthritis

•Moderate-to-severe ulcerative colitis (UC)

•Moderate-to-severe Crohn's disease (CD)
Pros and Cons of Cosentyx vs. Tremfya
Pros and Const for Interleukin 17 (IL-17) antagonist
Pros

•Generally injected once a month (might need a few starter doses)

•Available as prefilled syringes or pens for at-home injections

•Okay for some children (with plaque psoriasis, psoriatic arthritis, or enthesitis-related arthritis)

•Few side effects

Cons

•Must be given as an injection

•Might raise the risk of infections

•Might cause flare-ups in people with ulcerative colitis or Crohn's disease

•Pens and prefilled syringes might not be a good option for people with a latex allergy

Pros and Const for Interleukin antagonist
Pros

•An option for adults with plaque psoriasis who've already tried topical treatment

•Given every 1 or 2 months (depending on your condition and treatment plan)

•Few side effects

•Can give yourself injections under the skin at home after you get trained

Cons

•Given as an injection under the skin or injection through the vein

•Raises the risk of infections

•Can cause some injection site reactions

•Can take several months to see the benefits of the medication
Common Side Effects of Cosentyx vs. Tremfya
Common Side Effects for

•Common cold (11%)

•Diarrhea (4%)

•Upper respiratory tract infections (3%)

Common Side Effects for

•Upper respiratory infections (14%)

•Headache (5%)

•Injection site reactions (5%)

•Joint pain (3%)
Warnings of Cosentyx vs. Tremfya
Common Side Effects for

•Risk of infection

•Caution when getting vaccines

•Eczema-like skin reaction

•Allergic reaction

•Inflammatory bowel disease

Common Side Effects for

•Serious allergic reactions

•Risk of infections

•Liver damage

•Interaction with vaccines
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Compare Cosentyx vs. Tremfya

Key takeaways

Summary of Cosentyx vs. Tremfya

Indications of Cosentyx vs. Tremfya

Pros and Cons of Cosentyx vs. Tremfya

Common Side Effects of Cosentyx vs. Tremfya

Warnings of Cosentyx vs. Tremfya

Prices with our coupons for Cosentyx vs. Tremfya

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