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Stelara vs. Cimzia

Stelara (ustekinumab) is an injectable medication used to treat autoimmune conditions like plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. As an interleukin antagonist, it works by blocking certain proteins that cause inflammation in your body, which helps reduce swelling and ease symptoms. You typically get it as an injection under your skin. Common side effects include common cold symptoms, headache, and feeling tired. This medication also has many biosimilars available.

• Moderate-to-severe plaque psoriasis (Ps) - adults and children 6 years and older
• Psoriatic arthritis (PsA) - adults and children 6 years and older
• Moderate-to-severe Crohn's disease (CD) - adults only
• Moderate-to-severe ulcerative colitis (UC) - adults only

Plaque psoriasis

• Common cold symptoms (7-8%)
• Upper respiratory tract infection (4-5%)
• Headache (5%)

Psoriatic arthritis

• Joint pain (3%)
• Nausea (3%)

Crohn's disease

• Common cold symptoms (11%)
• Redness at the injection site (5%)
• Yeast infection (5%)
• Bronchitis (5%)

Ulcerative colitis:

• Common cold symptoms (24%)
• Headache (10%)
• Stomach pain (7%)
• Flu infection (6%)
• Fever (5%)

• Infections
• Cancers
• Severe allergic reaction
• Brain condition
• Vaccines
• Lung problems

Cimzia (certolizumab) is a prescription biologic used to treat several autoimmune conditions, like rheumatoid arthritis, psoriatic arthritis, and Crohn's disease. It works by blocking a protein called tumor necrosis factor (TNF), which helps reduce inflammation in your body. The medication is given as an injection under the skin every 2 to 4 weeks, depending on your condition. Common side effects include upper respiratory infections, urinary tract infections (UTIs), and skin rash.

• Moderate-to-severe Crohn's disease when other treatments haven't worked - adults only
• Moderate-to-severe rheumatoid arthritis (RA) - adults only
• Polyarticular juvenile idiopathic arthritis (pJIA) - adults children 2 years and older
• Psoriatic arthritis (PsA) - adults only
• Ankylosing spondylitis (AS) - adults only
• Non-radiographic axial spondyloarthritis (nr-axSpA) - adults only
• Moderate-to-severe plaque psoriasis (PsO) - adults only

• Upper respiratory infections (18%)
• Rash (9%)
• Urinary tract infections (8%)

• Serious infections
• Cancer
• Heart failure
• Allergic reactions
• Nervous system problems
• Blood problems
• Lupus-like condition
• Live vaccines