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Omvoh vs. Stelara

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Omvoh

(mirikizumab)

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Stelara

(ustekinumab)

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Summary for Omvoh

Prescription only

Omvoh (mirikizumab or mirikizumab-mrkz) helps treat ulcerative colitis and Crohn's disease in adults. It's a biologic known as an interleukin-23 antagonist. It works to help lower inflammation in the gut. When you first start, you'll get your first three doses as an infusion through the vein (IV) once a month at a clinic. After that, you (or your caregiver) can inject the rest of your doses under the skin every month at home. Side effects include joint pain and upper respiratory tract infections. Omvoh (mirikizumab) is available as a brand-name medication only.

Indications for Omvoh

Pros and Cons for Omvoh

Pros

  • Given once a month
  • Available as ready-to-inject prefilled pens and syringes after the first three infusions
  • Can inject maintenance doses at home with proper training
  • Can improve symptoms when other treatments haven't worked well

Cons

  • Injection only
  • Must get the first few doses as IV infusions from a healthcare professional
  • Can cause injection site reactions like redness, pain, and itchiness
  • Can raise your risk of getting sick more easily

Common Side Effects for Omvoh

Induction with IV infusions

Maintenance with under-the-skin injections

Warnings for Omvoh

  • Allergic reactions
  • Risk of infection
  • Liver injury
  • Avoid live vaccines

Summary for Stelara

Prescription only

Stelara (ustekinumab) is an injectable medication used to treat autoimmune conditions like plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. As an interleukin antagonist, it works by blocking certain proteins that cause inflammation in your body, which helps reduce swelling and ease symptoms. You typically get it as an injection under your skin. Common side effects include common cold symptoms, headache, and feeling tired. This medication also has many biosimilars available.

Indications for Stelara

Pros and Cons for Stelara

Pros

  • After the first few doses, only need a shot every 8 to 12 weeks
  • Available as a prefilled syringe or vial
  • Syringes can be stored at room temperature for up to 30 days
  • Approved for children as young as 6 years old

Cons

  • Can weaken your immune system and raise your risk of infection
  • Potential to cause serious allergic reactions
  • For CD and UC, the first dose must be given as an IV infusion
  • Can't receive live vaccines while taking this medication

Common Side Effects for Stelara

Plaque psoriasis

  • Common cold symptoms (7-8%)
  • Upper respiratory tract infection (4-5%)
  • Headache (5%)

Psoriatic arthritis

  • Joint pain (3%)
  • Nausea (3%)

Crohn's disease

  • Common cold symptoms (11%)
  • Redness at the injection site (5%)
  • Yeast infection (5%)
  • Bronchitis (5%)

Ulcerative colitis:

  • Common cold symptoms (24%)
  • Headache (10%)
  • Stomach pain (7%)
  • Flu infection (6%)
  • Fever (5%)

Warnings for Stelara

  • Infections
  • Cancers
  • Severe allergic reaction
  • Brain condition
  • Vaccines
  • Lung problems

Prices with our coupons for Omvoh vs. Stelara

Price Card Drug Icon
Omvoh1 carton / 2 pens of 100mg/ml
$10,971.98-
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Price Card Drug Icon
Ustekinumab1 syringe / 1ml of 90mg/ml
$7,002.73-
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