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Compare Rinvoq vs. Skyrizi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Rinvoq (upadacitinib) and Skyrizi (risankizumab) are both medications used to treat inflammatory conditions, such as psoriatic arthritis and Crohn's disease. However, they belong to different medication classes. Rinvoq is a Janus kinase (JAK) inhibitor, while Skyrizi is an interleukin antagonist. Rinvoq is taken orally, either as an extended-release tablet or an oral solution, and is typically taken once daily. In contrast, Skyrizi is administered as an injection, with dosing every 2 or 3 months after initial doses. Common side effects of Rinvoq include a higher risk of infections, acne, and nausea, while Skyrizi may cause joint pain and upper respiratory infections. Both medications can weaken your immune system and raise the risk of infections, but they have some different interactions and precautions. For example, you should avoid grapefruit with Rinvoq, and Skyrizi requires careful handling and storage.

  • Rinvoq (upadacitinib)
    Skyrizi (risankizumab)
  • Rinvoq (upadacitinib)
    Skyrizi (risankizumab)

  • Summary of Rinvoq vs. Skyrizi

    Summary for JAK inhibitor
    Prescription only

    Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor. It's used to treat certain inflammatory conditions, such as rheumatoid arthritis (RA), ulcerative colitis (UC), and eczema (atopic dermatitis). But it's not a first-choice option and typically only prescribed when other treatments haven't worked well. Rinvoq (upadacitinib) is taken by mouth, usually once daily. It's available as an extended-release tablet (Rinvoq) and an oral solution (Rinvoq LQ), but the two formulations aren't interchangeable. Side effects include a higher risk of infections, acne, and nausea.

    Summary for Interleukin antagonist
    Prescription only

    Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

  • Indications of Rinvoq vs. Skyrizi

    Indications for

    Moderate-to-severe inflammatory conditions in which other treatments haven't worked:

    •Rheumatoid arthritis (RA) in adults
    •Psoriatic arthritis (PsA) in adults and children ages 2 years and older
    •Eczema (atopic dermatitis) in adults and children ages 12 years and older
    •Ulcerative colitis (UC) in adults
    •Crohn's disease (CD) in adults
    •Ankylosing spondylitis (AS) in adults
    •Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
    •Polyarticular juvenile idiopathic arthritis (pJIA) in adults and children ages 2 years and older
    Indications for
    •Moderate-to-severe plaque psoriasis in adults
    •Psoriatic arthritis in adults
    •Moderate-to-severe Crohn's disease in adults
    •Moderate-to-severe ulcerative colitis in adults

  • Pros and Cons of Rinvoq vs. Skyrizi

    Pros and Const for JAK inhibitor
    Pros
    •Can treat many different inflammatory conditions
    •Available as a tablet and a liquid
    •The tablet only needs to be taken once a day
    Cons
    •Can raise risk for infections
    •Not the best option for people with severe liver or kidney problems
    •Not safe for use during pregnancy
    Pros and Const for Interleukin antagonist
    Pros
    •Given every 2 or 3 months after a couple of starter doses (depends on your condition)
    •Can give injections under the skin at home after you get trained
    Cons
    •Must be given as an injection
    •Not approved for children

  • Common Side Effects of Rinvoq vs. Skyrizi

    Common Side Effects for
    •Upper respiratory tract infection (25%)
    •Acne (16%)
    •Herpes simplex virus (HSV) infection (8%)
    •Headache (6%)

    Note: Side effects listed were reported by people who took Rinvoq for eczema.

    Common Side Effects for
    •Upper respiratory infections (13%)
    •Headache (4%)
    •Tiredness (3%)

  • Warnings of Rinvoq vs. Skyrizi

    Common Side Effects for
    •Serious infections
    •Possible higher risk of death for people with rheumatoid arthritis
    •Risk of cancer
    •Possible risk of heart attack, stroke, and other blood clots
    •Severe allergic reaction
    •Stomach and gut tears
    •Abnormal lab results (e.g., blood cell counts, cholesterol levels)
    •Possible harm to unborn babies
    •Medication in stool
    Common Side Effects for
    •Allergic reaction
    •Risk of infection
    •Rare case of liver injury
    •Caution when getting vaccines

  • Prices with our coupons for Rinvoq vs. Skyrizi

    Learn more about Rinvoq
    Learn more about Skyrizi

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