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Rinvoq vs. Skyrizi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Rinvoq (upadacitinib) and Skyrizi (risankizumab) are both medications used to treat inflammatory conditions, such as psoriatic arthritis and Crohn's disease. However, they belong to different medication classes. Rinvoq is a Janus kinase (JAK) inhibitor, while Skyrizi is an interleukin antagonist. Rinvoq is taken orally, either as an extended-release tablet or an oral solution, and is typically taken once daily. In contrast, Skyrizi is administered as an injection, with dosing every 2 or 3 months after initial doses. Common side effects of Rinvoq include a higher risk of infections, acne, and nausea, while Skyrizi may cause joint pain and upper respiratory infections. Both medications can weaken your immune system and raise the risk of infections, but they have some different interactions and precautions. For example, you should avoid grapefruit with Rinvoq, and Skyrizi requires careful handling and storage.

Rinvoq

(upadacitinib)

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Skyrizi

(risankizumab)

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Summary for Rinvoq

Prescription only

Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor. It treats many inflammatory conditions. This includes rheumatoid arthritis (RA), ulcerative colitis (UC), Crohn's disease (CD), and eczema (atopic dermatitis). It's often used when other treatments haven't worked well. Rinvoq (upadacitinib) is taken by mouth, usually once a day. It comes as an extended-release pill (Rinvoq) and an oral solution (Rinvoq LQ). These formulations aren't the same and can't be swapped easily. Side effects include nausea and a higher risk of infection.

Indications for Rinvoq

Pros and Cons for Rinvoq

Pros

  • Can treat many different inflammatory conditions
  • Available as a tablet and a liquid
  • Tablets are taken once a day

Cons

  • Can raise your risk of infections
  • Can interact with grapefruit
  • Not the best option for people with severe liver or kidney problems

Common Side Effects for Rinvoq

Warnings for Rinvoq

  • Serious infections
  • Possible higher risk of heart attack, stroke, or heart-related death in certain older adults with RA
  • Risk of cancer
  • Risk of blood clots
  • Allergic reactions
  • Stomach damage
  • Abnormal lab results (e.g., blood counts, cholesterol)
  • Harm to an unborn baby
  • Medication in stool

Summary for Skyrizi

Prescription only

Skyrizi (risankizumab or risankizumab-rzaa) is an injectable medication for many inflammatory conditions. It treats plaque psoriasis in adults and children ages 6 years and up. It can also treat psoriatic arthritis, Crohn's disease, and ulcerative colitis in adults. This medication works as an interleukin antagonist to help lower inflammation. After a few starter doses, it's given every 2 or 3 months, depending on the condition being treated. Side effects include a higher risk of infection.

Indications for Skyrizi

Pros and Cons for Skyrizi

Pros

  • Given every 2 or 3 months after the starter doses (depends on your condition)
  • Can give maintenance doses at home as injections under the skin after proper training
  • Approved for children as young as 6 years old with plaque psoriasis

Cons

  • Must be given as an injection
  • Can raise the risk of infection
  • Might take several weeks to months to work fully

Common Side Effects for Skyrizi

Warnings for Skyrizi

  • Allergic reaction
  • Risk of infection
  • Rare case of liver injury
  • Caution when getting vaccines

Prices with our coupons for Rinvoq vs. Skyrizi

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Rinvoq30 tablets / 15mg
$6,244.67$8,828.35
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Skyrizi1 package / 1 pen of 150mg/ml
$20,217.99-
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