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Compare Velsipity vs. Rinvoq

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Velsipity (etrasimod)
    Rinvoq (upadacitinib)
  • Velsipity (etrasimod)
    Rinvoq (upadacitinib)

  • Summary of Velsipity vs. Rinvoq

    Summary for S1P receptor modulator
    Prescription only

    Velsipity (etrasimod) is a medication that treats ulcerative colitis (UC) in adults. It works as a sphingosine 1-phosphate (S1P) receptor modulator to help relieve gut inflammation and symptoms of UC. The usual dose is 1 tablet by mouth once a day. Velsipity (etrasimod) can cause side effects like headache and dizziness. It also has a few serious risks, including infection, heart problems, and liver damage. Velsipity (etrasimod) is available as a brand-name medication.

    Summary for JAK inhibitor
    Prescription only

    Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor. It's used to treat certain inflammatory conditions, such as rheumatoid arthritis (RA), ulcerative colitis (UC), and eczema (atopic dermatitis). But it's not a first-choice option and typically only prescribed when other treatments haven't worked well. Rinvoq (upadacitinib) is taken by mouth, usually once daily. It's available as an extended-release tablet (Rinvoq) and an oral solution (Rinvoq LQ), but the two formulations aren't interchangeable. Side effects include a higher risk of infections, acne, and nausea.

  • Indications of Velsipity vs. Rinvoq

    Indications for
    •Moderate-to-severe ulcerative colitis (UC) in adults
    Indications for

    Moderate-to-severe inflammatory conditions in which other treatments haven't worked:

    •Rheumatoid arthritis (RA) in adults
    •Psoriatic arthritis (PsA) in adults and children ages 2 years and older
    •Eczema (atopic dermatitis) in adults and children ages 12 years and older
    •Ulcerative colitis (UC) in adults
    •Crohn's disease (CD) in adults
    •Ankylosing spondylitis (AS) in adults
    •Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
    •Polyarticular juvenile idiopathic arthritis (pJIA) in adults and children ages 2 years and older

  • Pros and Cons of Velsipity vs. Rinvoq

    Pros and Const for S1P receptor modulator
    Pros
    •Taken by mouth, with or without food
    •Only taken once a day
    •Can be an option when other medications for UC haven't worked well enough
    Cons
    •Risk of serious infections
    •Might interact with vaccines or immunosuppressants
    •Might not be safe if you have heart problems or severe liver problems
    Pros and Const for JAK inhibitor
    Pros
    •Can treat many different inflammatory conditions
    •Available as a tablet and a liquid
    •The tablet only needs to be taken once a day
    Cons
    •Can raise risk for infections
    •Not the best option for people with severe liver or kidney problems
    •Not safe for use during pregnancy

  • Common Side Effects of Velsipity vs. Rinvoq

    Common Side Effects for
    •Headache (9%)
    •Higher liver enzyme levels (6%)
    •Dizziness (5%)
    Common Side Effects for
    •Upper respiratory tract infection (25%)
    •Acne (16%)
    •Herpes simplex virus (HSV) infection (8%)
    •Headache (6%)

    Note: Side effects listed were reported by people who took Rinvoq for eczema.

  • Warnings of Velsipity vs. Rinvoq

    Common Side Effects for
    •Risk of infections
    •Slow heart rhythm and heart rate
    •High blood pressure
    •Liver problems
    •Eye problem (macular edema)
    •Harm to an unborn baby
    •Possible risk of skin cancer
    •Brain problems
    •Breathing problems
    Common Side Effects for
    •Serious infections
    •Possible higher risk of death for people with rheumatoid arthritis
    •Risk of cancer
    •Possible risk of heart attack, stroke, and other blood clots
    •Severe allergic reaction
    •Stomach and gut tears
    •Abnormal lab results (e.g., blood cell counts, cholesterol levels)
    •Possible harm to unborn babies
    •Medication in stool

  • Prices with our coupons for Velsipity vs. Rinvoq

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    Learn more about Rinvoq

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