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Compare Entyvio vs. Rinvoq

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Vedolizumab (Entyvio) and upadacitinib (Rinvoq) are both Disease-Modifying Antirheumatic Drugs (DMARDs) used to treat ulcerative colitis (UC) and Crohn's disease (CD), but there are some important differences. Vedolizumab is an integrin antagonist, while upadacitinib is a Janus kinase (JAK) inhibitor. Vedolizumab is administered either as an intravenous infusion or a subcutaneous injection, whereas upadacitinib is taken orally as a tablet or liquid. Vedolizumab is specifically approved for moderate-to-severe UC and CD in adults, while upadacitinib is used for a broader range of inflammatory conditions, including rheumatoid arthritis and eczema, and is typically prescribed when other treatments haven't worked. Common side effects of vedolizumab include headache and joint pain, while upadacitinib may cause acne and nausea. Both medications can increase the risk of infections, but upadacitinib also carries risks of blood clots and potential harm during pregnancy. Both are only available as a branded medication.

  • Entyvio (vedolizumab)
    Rinvoq (upadacitinib)
  • Entyvio (vedolizumab)
    Rinvoq (upadacitinib)

  • Summary of Entyvio vs. Rinvoq

    Summary for Integrin antagonist
    Prescription only

    Entyvio, the brand name for vedolizumab, is an injection used to treat ulcerative colitis (UC) and Crohn's disease (CD) in adults. It belongs to a drug class called integrin antagonists that helps lower inflammation in the gut. Entyvio (vedolizumab) is an infusion that's given through the vein by a healthcare professional. After the first 2 doses, it's usually given every 2 months. If it works well, people can switch to injections under the skin every 2 weeks using prefilled syringes or pens. Side effects include headache, mild infections, and joint pain.

    Summary for JAK inhibitor
    Prescription only

    Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor. It's used to treat certain inflammatory conditions, such as rheumatoid arthritis (RA), ulcerative colitis (UC), and eczema (atopic dermatitis). But it's not a first-choice option and typically only prescribed when other treatments haven't worked well. Rinvoq (upadacitinib) is taken by mouth, usually once daily. It's available as an extended-release tablet (Rinvoq) and an oral solution (Rinvoq LQ), but the two formulations aren't interchangeable. Side effects include a higher risk of infections, acne, and nausea.

  • Indications of Entyvio vs. Rinvoq

    Indications for
    •Moderate-to-severe ulcerative colitis (UC) in adults
    •Moderate-to-severe Crohn's disease (CD) in adults
    Indications for

    Moderate-to-severe inflammatory conditions in which other treatments haven't worked:

    •Rheumatoid arthritis (RA) in adults
    •Psoriatic arthritis (PsA) in adults and children ages 2 years and older
    •Eczema (atopic dermatitis) in adults and children ages 12 years and older
    •Ulcerative colitis (UC) in adults
    •Crohn's disease (CD) in adults
    •Ankylosing spondylitis (AS) in adults
    •Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
    •Polyarticular juvenile idiopathic arthritis (pJIA) in adults and children ages 2 years and older

  • Pros and Cons of Entyvio vs. Rinvoq

    Pros and Const for Integrin antagonist
    Pros
    •Have the option for infusions through the vein or injections under the skin after 6 weeks of treatment
    •Comes as prefilled syringes and pens for injections under the skin that can be given at home
    Cons
    •IV infusions can only be given by a healthcare professional at a medical office
    •Can raise your risk of serious side effects, like infusion reactions and infections
    Pros and Const for JAK inhibitor
    Pros
    •Can treat many different inflammatory conditions
    •Available as a tablet and a liquid
    •The tablet only needs to be taken once a day
    Cons
    •Can raise risk for infections
    •Not the best option for people with severe liver or kidney problems
    •Not safe for use during pregnancy

  • Common Side Effects of Entyvio vs. Rinvoq

    Common Side Effects for
    •Infection in nose and throat (13%)
    •Headache (12%)
    •Joint pain (12%)
    •Nausea (9%)
    •Fever (9%)
    •Upper respiratory tract infection (7%)
    •Fatigue (6%)
    •Cough (5%)
    Common Side Effects for
    •Upper respiratory tract infection (25%)
    •Acne (16%)
    •Herpes simplex virus (HSV) infection (8%)
    •Headache (6%)

    Note: Side effects listed were reported by people who took Rinvoq for eczema.

  • Warnings of Entyvio vs. Rinvoq

    Common Side Effects for
    •Infusion-related reactions and allergic reactions
    •Risk of serious infections
    •Risk of brain infection (progressive multifocal leukoencephalopathy)
    •Liver problems
    Common Side Effects for
    •Serious infections
    •Possible higher risk of death for people with rheumatoid arthritis
    •Risk of cancer
    •Possible risk of heart attack, stroke, and other blood clots
    •Severe allergic reaction
    •Stomach and gut tears
    •Abnormal lab results (e.g., blood cell counts, cholesterol levels)
    •Possible harm to unborn babies
    •Medication in stool

  • Prices with our coupons for Entyvio vs. Rinvoq

    Learn more about Entyvio
    Learn more about Rinvoq

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