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Compare Rinvoq vs. Zeposia

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Rinvoq (upadacitinib)
    zeposia (ozanimod)
  • Rinvoq (upadacitinib)
    zeposia (ozanimod)

  • Summary of Rinvoq vs. Zeposia

    Summary for JAK inhibitor
    Prescription only

    Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor. It's used to treat certain inflammatory conditions, such as rheumatoid arthritis (RA), ulcerative colitis (UC), and eczema (atopic dermatitis). But it's not a first-choice option and typically only prescribed when other treatments haven't worked well. Rinvoq (upadacitinib) is taken by mouth, usually once daily. It's available as an extended-release tablet (Rinvoq) and an oral solution (Rinvoq LQ), but the two formulations aren't interchangeable. Side effects include a higher risk of infections, acne, and nausea.

    Summary for Sphingosine 1-phosphate receptor modulator
    Prescription only

    Zeposia (ozanimod) is a sphingosine 1-phosphate (S1P) receptor modulator that's used to treat adults with ulcerative colitis (UC) or relapsing forms of multiple sclerosis (MS). It's a capsule that's taken by mouth, usually once per day (or as directed by your provider if you have certain liver problems). There are starter packs of the medication that help you slowly raise the dosage to a maintenance dosage over a week. Side effects typically depend on your medical condition, but generally include infections and changes in liver tests.

  • Indications of Rinvoq vs. Zeposia

    Indications for

    Moderate-to-severe inflammatory conditions in which other treatments haven't worked:

    •Rheumatoid arthritis (RA) in adults
    •Psoriatic arthritis (PsA) in adults and children ages 2 years and older
    •Eczema (atopic dermatitis) in adults and children ages 12 years and older
    •Ulcerative colitis (UC) in adults
    •Crohn's disease (CD) in adults
    •Ankylosing spondylitis (AS) in adults
    •Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
    •Polyarticular juvenile idiopathic arthritis (pJIA) in adults and children ages 2 years and older
    Indications for
    •Relapsing forms of multiple sclerosis (MS) in adults
    •Moderate-to-severe ulcerative colitis (UC) in adults

  • Pros and Cons of Rinvoq vs. Zeposia

    Pros and Const for JAK inhibitor
    Pros
    •Can treat many different inflammatory conditions
    •Available as a tablet and a liquid
    •The tablet only needs to be taken once a day
    Cons
    •Can raise risk for infections
    •Not the best option for people with severe liver or kidney problems
    •Not safe for use during pregnancy
    Pros and Const for Sphingosine 1-phosphate receptor modulator
    Pros
    •Only need to take up to once daily
    •7-capsule starter pack available to help make it easier to know what dose to take at the beginning of treatment
    •Can start to work within a couple weeks to improve UC symptoms
    •Many people with MS are relapse-free after taking this medication for 1 year
    Cons
    •Must raise your dose slowly over the first week of treatment, which can be confusing
    •Might raise your risk of infections
    •Unknown if it works well or is safe to use for children under 18 years of age
    •Not recommended for use in people with severe liver problems

  • Common Side Effects of Rinvoq vs. Zeposia

    Common Side Effects for
    •Upper respiratory tract infection (25%)
    •Acne (16%)
    •Herpes simplex virus (HSV) infection (8%)
    •Headache (6%)

    Note: Side effects listed were reported by people who took Rinvoq for eczema.

    Common Side Effects for
    •Upper respiratory infection (26%)
    •High liver enzyme tests (10%)

  • Warnings of Rinvoq vs. Zeposia

    Common Side Effects for
    •Serious infections
    •Possible higher risk of death for people with rheumatoid arthritis
    •Risk of cancer
    •Possible risk of heart attack, stroke, and other blood clots
    •Severe allergic reaction
    •Stomach and gut tears
    •Abnormal lab results (e.g., blood cell counts, cholesterol levels)
    •Possible harm to unborn babies
    •Medication in stool
    Common Side Effects for
    •Serious infections
    •Progressive multifocal leukoencephalopathy (PML)
    •Dangerously slow heart rate
    •High blood pressure
    •Liver damage
    •Harm to unborn babies
    •Breathing problems
    •Eye problems
    •Brain problem called posterior reversible encephalopathy syndrome (PRES)

  • Prices with our coupons for Rinvoq vs. Zeposia

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    Learn more about zeposia

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