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Compare Rinvoq vs. Zeposia

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Rinvoq (upadacitinib) and Zeposia (ozanimod) are both medications used to treat ulcerative colitis (UC), but they belong to different drug classes. Rinvoq is a Janus kinase (JAK) inhibitor, while Zeposia is a sphingosine 1-phosphate (S1P) receptor modulator. Rinvoq is also used for a variety of other inflammatory conditions, such as rheumatoid arthritis and eczema, whereas Zeposia is additionally approved for relapsing forms of multiple sclerosis (MS). Rinvoq is available as an extended-release tablet and an oral solution, typically taken once daily, while Zeposia is taken as a capsule once daily, with a starter pack to gradually increase the dose. Common side effects of Rinvoq include infections and acne, while Zeposia may cause upper respiratory infections and changes in liver tests. Both medications can increase the risk of infections, but Zeposia also has specific warnings about changes in heart rate and blood pressure. Both medications require careful monitoring for side effects and interactions with other medications.

Rinvoq (upadacitinib)
Zeposia (ozanimod)
Rinvoq (upadacitinib)
Zeposia (ozanimod)
Summary of Rinvoq vs. Zeposia
Summary for JAK inhibitor
Prescription only
Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor. It's used to treat certain inflammatory conditions, such as rheumatoid arthritis (RA), ulcerative colitis (UC), and eczema (atopic dermatitis). But it's not a first-choice option and typically only prescribed when other treatments haven't worked well. Rinvoq (upadacitinib) is taken by mouth, usually once daily. It's available as an extended-release tablet (Rinvoq) and an oral solution (Rinvoq LQ), but the two formulations aren't interchangeable. Side effects include a higher risk of infections, acne, and nausea.
Summary for S1P receptor modulator
Prescription only
Zeposia (ozanimod) treats adults with relapsing forms of multiple sclerosis (MS). This medication can also treat adults with ulcerative colitis (UC). It works as a sphingosine 1-phosphate (S1P) receptor modulator to relieve inflammation in the body. It's a capsule you take by mouth, usually once per day (or as directed by your prescriber if you have liver problems). You use a starter pack for the first week. It helps you slowly raise your dosage to a maintenance level. Side effects include upper respiratory infections and higher liver enzymes. Zeposia (ozanimod) is only available as a brand-name medication.
Indications of Rinvoq vs. Zeposia
Indications for
Moderate-to-severe inflammatory conditions in which other treatments haven't worked:

•Rheumatoid arthritis (RA) in adults

•Psoriatic arthritis (PsA) in adults and children ages 2 years and older

•Eczema (atopic dermatitis) in adults and children ages 12 years and older

•Ulcerative colitis (UC) in adults

•Crohn's disease (CD) in adults

•Ankylosing spondylitis (AS) in adults

•Non-radiographic axial spondyloarthritis (nr-axSpA) in adults

•Polyarticular juvenile idiopathic arthritis (pJIA) in adults and children ages 2 years and older

Indications for

•Relapsing forms of multiple sclerosis (MS) in adults

•Moderate-to-severe ulcerative colitis (UC) in adults
Pros and Cons of Rinvoq vs. Zeposia
Pros and Const for JAK inhibitor
Pros

•Can treat many different inflammatory conditions

•Available as a tablet and a liquid

•The tablet only needs to be taken once a day

Cons

•Can raise risk for infections

•Not the best option for people with severe liver or kidney problems

•Not safe for use during pregnancy

Pros and Const for S1P receptor modulator
Pros

•Taken by mouth, with or without food

•Taken once a day

•Starter pack available to help guide dosing at the beginning of treatment

Cons

•Might raise your risk of infections

•Not safe for people with certain heart problems or severe liver problems

•Not approved for children
Common Side Effects of Rinvoq vs. Zeposia
Common Side Effects for

•Upper respiratory tract infection (25%)

•Acne (16%)

•Herpes simplex virus (HSV) infection (8%)

•Headache (6%)

Note: Side effects listed were reported by people who took Rinvoq for eczema.
Common Side Effects for

•Upper respiratory infection (26%)

•High liver enzyme levels (10%)
Warnings of Rinvoq vs. Zeposia
Common Side Effects for

•Serious infections

•Possible higher risk of death for people with rheumatoid arthritis

•Risk of cancer

•Possible risk of heart attack, stroke, and other blood clots

•Severe allergic reaction

•Stomach and gut tears

•Abnormal lab results (e.g., blood cell counts, cholesterol levels)

•Possible harm to unborn babies

•Medication in stool

Common Side Effects for

•Risk of infections

•Risk of brain infection (progressive multifocal leukoencephalopathy)

•Slow heart rate and heart rhythm

•Higher blood pressure

•Liver damage

•Breathing problems

•Eye problem called macular edema

•Brain problem called posterior reversible encephalopathy syndrome (PRES)

•Possible risk of skin cancer

•Harm to an unborn baby
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Compare Rinvoq vs. Zeposia

Key takeaways

Summary of Rinvoq vs. Zeposia

Indications of Rinvoq vs. Zeposia

Pros and Cons of Rinvoq vs. Zeposia

Common Side Effects of Rinvoq vs. Zeposia

Warnings of Rinvoq vs. Zeposia

Prices with our coupons for Rinvoq vs. Zeposia

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