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Compare Zeposia vs. Entyvio

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Zeposia (ozanimod) and Entyvio (vedolizumab) are both medications used to treat ulcerative colitis (UC) in adults. However, they belong to different medication classes and have distinct uses and administration methods. Zeposia is a sphingosine 1-phosphate receptor modulator also approved for relapsing forms of multiple sclerosis (MS), while Entyvio is an integrin antagonist also used for Crohn's disease (CD). Zeposia is taken orally once daily, whereas Entyvio is administered either as an intravenous infusion every two months or as a subcutaneous injection every two weeks. Common side effects of Zeposia include infections and changes in liver tests, while Entyvio may cause headaches, mild infections, and joint pain. You should avoid foods high in tyramine (e.g., aged cheeses, pickled or fermented foods, or alcohol) while taking Zeposia.

  • Zeposia (ozanimod)
    Entyvio (vedolizumab)
  • Zeposia (ozanimod)
    Entyvio (vedolizumab)

  • Summary of Zeposia vs. Entyvio

    Summary for S1P receptor modulator
    Prescription only

    Zeposia (ozanimod) treats adults with relapsing forms of multiple sclerosis (MS). This medication can also treat adults with ulcerative colitis (UC). It works as a sphingosine 1-phosphate (S1P) receptor modulator to relieve inflammation in the body. It's a capsule you take by mouth, usually once per day (or as directed by your prescriber if you have liver problems). You use a starter pack for the first week. It helps you slowly raise your dosage to a maintenance level. Side effects include upper respiratory infections and higher liver enzymes. Zeposia (ozanimod) is only available as a brand-name medication.

    Summary for Integrin antagonist
    Prescription only

    Entyvio, the brand name for vedolizumab, is an injection used to treat ulcerative colitis (UC) and Crohn's disease (CD) in adults. It belongs to a drug class called integrin antagonists that helps lower inflammation in the gut. Entyvio (vedolizumab) is an infusion that's given through the vein by a healthcare professional. After the first 2 doses, it's usually given every 2 months. If it works well, people can switch to injections under the skin every 2 weeks using prefilled syringes or pens. Side effects include headache, mild infections, and joint pain.

  • Indications of Zeposia vs. Entyvio

    Indications for
    •Relapsing forms of multiple sclerosis (MS) in adults
    •Moderate-to-severe ulcerative colitis (UC) in adults
    Indications for
    •Moderate-to-severe ulcerative colitis (UC) in adults
    •Moderate-to-severe Crohn's disease (CD) in adults

  • Pros and Cons of Zeposia vs. Entyvio

    Pros and Const for S1P receptor modulator
    Pros
    •Taken by mouth, with or without food
    •Taken once a day
    •Starter pack available to help guide dosing at the beginning of treatment
    Cons
    •Might raise your risk of infections
    •Not safe for people with certain heart problems or severe liver problems
    •Not approved for children
    Pros and Const for Integrin antagonist
    Pros
    •Have the option for infusions through the vein or injections under the skin after 6 weeks of treatment
    •Comes as prefilled syringes and pens for injections under the skin that can be given at home
    Cons
    •IV infusions can only be given by a healthcare professional at a medical office
    •Can raise your risk of serious side effects, like infusion reactions and infections

  • Common Side Effects of Zeposia vs. Entyvio

    Common Side Effects for
    •Upper respiratory infection (26%)
    •High liver enzyme levels (10%)
    Common Side Effects for
    •Infection in nose and throat (13%)
    •Headache (12%)
    •Joint pain (12%)
    •Nausea (9%)
    •Fever (9%)
    •Upper respiratory tract infection (7%)
    •Fatigue (6%)
    •Cough (5%)

  • Warnings of Zeposia vs. Entyvio

    Common Side Effects for
    •Risk of infections
    •Risk of brain infection (progressive multifocal leukoencephalopathy)
    •Slow heart rate and heart rhythm
    •Higher blood pressure
    •Liver damage
    •Breathing problems
    •Eye problem called macular edema
    •Brain problem called posterior reversible encephalopathy syndrome (PRES)
    •Possible risk of skin cancer
    •Harm to an unborn baby
    Common Side Effects for
    •Infusion-related reactions and allergic reactions
    •Risk of serious infections
    •Risk of brain infection (progressive multifocal leukoencephalopathy)
    •Liver problems

  • Prices with our coupons for Zeposia vs. Entyvio

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