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Compare Mayzent vs. Rebif

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Mayzent (siponimod) and Rebif (interferon beta-1a) are both used to treat relapsing multiple sclerosis (MS), but they have some key differences. Mayzent is taken orally once daily as a tablet, while Rebif is an injected three times a week. Mayzent works by blocking white blood cells from leaving the lymph nodes, which helps reduce nerve damage, whereas Rebif is a biologic that affects cell processes through interferons, though its exact mechanism for treating MS is not fully understood. Mayzent requires genetic testing before starting treatment to determine the appropriate dose, while Rebif does not. Common side effects of Mayzent include headache and high blood pressure, while Rebif often causes flu-like symptoms and injection site reactions. Additionally, both medications are only available as a brand-name and can lower white blood cell counts.

  • Mayzent (siponimod)
    Rebif (interferon beta-1a)
  • Mayzent (siponimod)
    Rebif (interferon beta-1a)

  • Summary of Mayzent vs. Rebif

    Summary for Sphingosine 1-phosphate receptor modulator
    Prescription only

    Mayzent (siponimod) is a disease-modifying treatment option for relapsing multiple sclerosis (MS) in adults. It can lower the chances of worsening MS and lower the number of MS relapses. Mayzent (siponimod) is a tablet that's taken by mouth. Common side effects include headache, high blood pressure, and falls. Mayzent (siponimod) is currently available as a brand-name only.

    Summary for Biologic
    Prescription only

    Rebif (interferon beta-1a) is an injectable biologic used for the treatment of relapsing multiple sclerosis (MS). However, it can cause uncomfortable flu-like symptoms as a side effect.

  • Indications of Mayzent vs. Rebif

    Indications for
    •Relapsing forms of multiple sclerosis (MS)
    Indications for
    •Relapsing forms of multiple sclerosis (MS)

  • Pros and Cons of Mayzent vs. Rebif

    Pros and Const for Sphingosine 1-phosphate receptor modulator
    Pros
    •Works well to slow worsening of MS and lower the number of MS relapses
    •Taken by mouth once per day
    •Doesn't require frequent visits to the clinic or infusion center to receive your dose
    Cons
    •Requires several tests before starting (e.g., genetic testing, electrocardiogram, blood tests)
    •Might not be a good option for people with heart or serious liver problems
    •Not safe during pregnancy
    Pros and Const for Biologic
    Pros
    •A disease-modifying therapy (DMT) that prevents worsening MS
    •One of the first DMTs approved for MS, so theres a lot of research and experience
    •Comes as an autoinjector pen and prefilled syringe for easy at-home injections
    •Can be stored at room temperature for up to 30 days
    Cons
    •Needs to be injected 3 times a week (more often than alternative medications like Avonex)
    •Not a first-choice treatment option for relapsing MS
    •Has many unpleasant side effects
    •Might not be a good option for people with a history of mental health conditions

  • Common Side Effects of Mayzent vs. Rebif

    Common Side Effects for
    •Headache (15%)
    •High blood pressure (13%)
    •Higher liver enzyme levels in the blood (11%)
    •Falls (11%)
    •Swelling of the arms and legs (edema, 8%)
    •Nausea (7%)
    •Dizziness (7%)
    •Diarrhea (6%)
    •Low heart rate (6%)
    •Pain in arms or legs (6%)
    Common Side Effects for
    •Injection-site reaction (89%)
    •Headache (65%)
    •Flu-like symptoms (56%)
    •Fatigue (33%)
    •Fever (25%)
    •Muscle pain (25%)
    •Stomach pain (22%)

  • Warnings of Mayzent vs. Rebif

    Common Side Effects for
    •Infections
    •Eye problems
    •Slow heart rate
    •Breathing problems
    •Liver damage
    •Risk of skin cancer
    •Harm to unborn babies
    •Brain problem called posterior reversible encephalopathy syndrome (PRES)
    Common Side Effects for
    •Mental health
    •Liver damage
    •Injection site reactions and infections
    •Lower blood cell counts
    •Seizures

  • Prices with our coupons for Mayzent vs. Rebif

    Learn more about Mayzent
    Learn more about Rebif

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