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Compare Vumerity vs. Mayzent

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Vumerity (diroximel fumarate) and Mayzent (siponimod) are both used to treat relapsing forms of multiple sclerosis (MS), but they work in different ways and have different dosing schedules. Vumerity is a fumaric acid derivative taken twice daily, while Mayzent is a sphingosine 1-phosphate receptor modulator taken once daily. Mayzent requires genetic testing before starting to determine the correct dose, which is not necessary for Vumerity. Vumerity's exact mechanism is unknown but is thought to reduce inflammation, whereas Mayzent blocks white blood cells from leaving lymph nodes, reducing nerve damage. Vumerity can cause side effects like flushing and stomach upset, while Mayzent can cause headaches, high blood pressure, and high liver enzyme levels. Both medications are only available as brand-name and can cause liver problems and serious infections. Additionally, Mayzent also increases the risk of skin cancer and can cause eye and breathing problems.

  • Vumerity (diroximel fumarate)
    Mayzent (siponimod)
  • Vumerity (diroximel fumarate)
    Mayzent (siponimod)

  • Summary of Vumerity vs. Mayzent

    Summary for Fumaric acid derivative
    Prescription only

    Vumerity, also known by its generic name dimethyl fumarate, is approved in adults for treating relapsing forms of multiple sclerosis (MS). It belongs to the drug class called fumaric acid derivatives. Vumerity (diroximel fumarate) is a capsule that's taken by mouth twice per day. The most common side effects are stomach upset and flushing (e.g., facial warmth, redness, burning sensation).

    Summary for Sphingosine 1-phosphate receptor modulator
    Prescription only

    Mayzent (siponimod) is a disease-modifying treatment option for relapsing multiple sclerosis (MS) in adults. It can lower the chances of worsening MS and lower the number of MS relapses. Mayzent (siponimod) is a tablet that's taken by mouth. Common side effects include headache, high blood pressure, and falls. Mayzent (siponimod) is currently available as a brand-name only.

  • Indications of Vumerity vs. Mayzent

    Indications for
    •Relapsing forms of multiple sclerosis (MS)
    Indications for
    •Relapsing forms of multiple sclerosis (MS)

  • Pros and Cons of Vumerity vs. Mayzent

    Pros and Const for Fumaric acid derivative
    Pros
    •Lessens the number of relapses per year
    •Available in a "starter dose" bottle and "maintenance dose" bottle to help you keep track of how much medication to take
    •Few interactions with other medications
    Cons
    •Have to take twice per day
    •Flushing is a common side effect
    •Shouldn't take the medication with high-fat and high-calorie meals
    Pros and Const for Sphingosine 1-phosphate receptor modulator
    Pros
    •Works well to slow worsening of MS and lower the number of MS relapses
    •Taken by mouth once per day
    •Doesn't require frequent visits to the clinic or infusion center to receive your dose
    Cons
    •Requires several tests before starting (e.g., genetic testing, electrocardiogram, blood tests)
    •Might not be a good option for people with heart or serious liver problems
    •Not safe during pregnancy

  • Common Side Effects of Vumerity vs. Mayzent

    Common Side Effects for
    •Flushing (40%)
    •Stomach pain (18%)
    •Diarrhea (14%)
    •Nausea (12%)
    Common Side Effects for
    •Headache (15%)
    •High blood pressure (13%)
    •Higher liver enzyme levels in the blood (11%)
    •Falls (11%)
    •Swelling of the arms and legs (edema, 8%)
    •Nausea (7%)
    •Dizziness (7%)
    •Diarrhea (6%)
    •Low heart rate (6%)
    •Pain in arms or legs (6%)

  • Warnings of Vumerity vs. Mayzent

    Common Side Effects for
    •Severe allergic reaction
    •Flushing
    •Risk for serious infections
    •Low white blood cell counts (lymphopenia)
    •Liver damage
    •Serious stomach and gut problems
    Common Side Effects for
    •Infections
    •Eye problems
    •Slow heart rate
    •Breathing problems
    •Liver damage
    •Risk of skin cancer
    •Harm to unborn babies
    •Brain problem called posterior reversible encephalopathy syndrome (PRES)

  • Prices with our coupons for Vumerity vs. Mayzent

    Learn more about Vumerity
    Learn more about Mayzent

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