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Mayzent vs. Tysabri

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Mayzent (siponimod) and Tysabri (natalizumab) are both used to treat relapsing forms of multiple sclerosis (MS), but they have some key differences. Of note, Tysabri has an additional indication for Crohn's Disese (CD). Mayzent is taken orally as a tablet once a day, while Tysabri is given as an intravenous (IV) infusion once a month. Mayzent requires genetic testing before starting treatment to determine the appropriate dose, whereas Tysabri requires enrollment in the TOUCH Prescribing Program due to its risk of serious infections like progressive multifocal leukoencephalopathy (PML). Mayzent can cause side effects such as headache, high blood pressure, and falls, while Tysabri can lead to headaches, fatigue, and urinary tract infections. Additionally, Mayzent is not safe during pregnancy, and Tysabri's safety during pregnancy is not well established. Both are only available as brand-name medications.

Mayzent

(siponimod)

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Tysabri

(natalizumab)

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Summary for Mayzent

Prescription only

Mayzent (siponimod) is a disease-modifying treatment option for relapsing multiple sclerosis (MS) in adults. It can lower the chances of worsening MS and lower the number of MS relapses. Mayzent (siponimod) is a tablet that's taken by mouth. Common side effects include headache, high blood pressure, and falls. Mayzent (siponimod) is currently available as a brand-name only.

Indications for Mayzent

  • Relapsing forms of multiple sclerosis (MS)

Pros and Cons for Mayzent

Pros

  • Works well to slow worsening of MS and lower the number of MS relapses
  • Taken by mouth once per day
  • Doesn't require frequent visits to the clinic or infusion center to receive your dose

Cons

  • Requires several tests before starting (e.g., genetic testing, electrocardiogram, blood tests)
  • Might not be a good option for people with heart or serious liver problems
  • Not safe during pregnancy

Common Side Effects for Mayzent

  • Headache (15%)
  • High blood pressure (13%)
  • Higher liver enzyme levels in the blood (11%)
  • Falls (11%)
  • Swelling of the arms and legs (edema, 8%)
  • Nausea (7%)
  • Dizziness (7%)
  • Diarrhea (6%)
  • Low heart rate (6%)
  • Pain in arms or legs (6%)

Warnings for Mayzent

  • Infections
  • Eye problems
  • Slow heart rate
  • Breathing problems
  • Liver damage
  • Risk of skin cancer
  • Harm to unborn babies
  • Brain problem called posterior reversible encephalopathy syndrome (PRES)

Summary for Tysabri

Prescription only

Tysabri (natalizumab) treats relapsing forms of multiple sclerosis (MS) and moderate-to-severe Crohn's disease (CD) in adults. This medication is a monoclonal antibody that works as an integrin antagonist. It lowers the immune system's activity and lessens inflammation. Tysabri (natalizumab) is given by a healthcare professional as a once-monthly infusion through the vein (IV). Common side effects include headache and fatigue. Because of the risk for serious infection, your care team will help you enroll in the TOUCH Prescribing Program and review the medication's warnings before treatment starts.

Indications for Tysabri

Pros and Cons for Tysabri

Pros

  • Infusions are once every month
  • Can be used for CD or MS
  • Has a risk monitoring program that anyone who prescribes, dispenses, infuses, or receives the medication must enroll in to make sure it's safe for you

Cons

  • Must be given by a healthcare professional in a healthcare setting
  • Infusions take about an hour
  • Raises your risk for serious infection
  • Only FDA approved for adults

Common Side Effects for Tysabri

Warnings for Tysabri

  • Progressive multifocal leukoencephalopathy (PML)
  • Other infections
  • Liver problems
  • Allergic reaction or infusion reaction
  • Low platelet levels

Prices with our coupons for Mayzent vs. Tysabri

Price Card Drug Icon
Mayzent30 tablets / 2mg
$10,265.34-
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Tysabri1 vial / 15ml of 300mg/15ml
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