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Compare Mayzent vs. Tysabri

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Mayzent (siponimod) and Tysabri (natalizumab) are both used to treat relapsing forms of multiple sclerosis (MS), but they have some key differences. Of note, Tysabri has an additional indication for Crohn's Disese (CD). Mayzent is taken orally as a tablet once a day, while Tysabri is given as an intravenous (IV) infusion once a month. Mayzent requires genetic testing before starting treatment to determine the appropriate dose, whereas Tysabri requires enrollment in the TOUCH Prescribing Program due to its risk of serious infections like progressive multifocal leukoencephalopathy (PML). Mayzent can cause side effects such as headache, high blood pressure, and falls, while Tysabri can lead to headaches, fatigue, and urinary tract infections. Additionally, Mayzent is not safe during pregnancy, and Tysabri's safety during pregnancy is not well established. Both are only available as brand-name medications.

  • Mayzent (siponimod)
    Tysabri (natalizumab)
  • Mayzent (siponimod)
    Tysabri (natalizumab)

  • Summary of Mayzent vs. Tysabri

    Summary for Sphingosine 1-phosphate receptor modulator
    Prescription only

    Mayzent (siponimod) is a disease-modifying treatment option for relapsing multiple sclerosis (MS) in adults. It can lower the chances of worsening MS and lower the number of MS relapses. Mayzent (siponimod) is a tablet that's taken by mouth. Common side effects include headache, high blood pressure, and falls. Mayzent (siponimod) is currently available as a brand-name only.

    Summary for Integrin receptor antagonist
    Prescription only

    Tysabri (natalizumab) treats relapsing forms of multiple sclerosis (MS) and moderate-to-severe Crohn's disease (CD) in adults. This medication is a monoclonal antibody that works as an integrin antagonist. It lowers the immune system's activity and lessens inflammation. Tysabri (natalizumab) is given by a healthcare professional as a once-monthly infusion through the vein (IV). Common side effects include headache and fatigue. Because of the risk for serious infection, your care team will help you enroll in the TOUCH Prescribing Program and review the medication's warnings before treatment starts.

  • Indications of Mayzent vs. Tysabri

    Indications for
    •Relapsing forms of multiple sclerosis (MS)
    Indications for
    •Relapsing forms of multiple sclerosis (MS)
    •Moderate-to-severe Crohn's disease (CD) when other treatments haven't worked well

  • Pros and Cons of Mayzent vs. Tysabri

    Pros and Const for Sphingosine 1-phosphate receptor modulator
    Pros
    •Works well to slow worsening of MS and lower the number of MS relapses
    •Taken by mouth once per day
    •Doesn't require frequent visits to the clinic or infusion center to receive your dose
    Cons
    •Requires several tests before starting (e.g., genetic testing, electrocardiogram, blood tests)
    •Might not be a good option for people with heart or serious liver problems
    •Not safe during pregnancy
    Pros and Const for Integrin receptor antagonist
    Pros
    •Infusions are once every month
    •Can be used for CD or MS
    •Has a risk monitoring program that anyone who prescribes, dispenses, infuses, or receives the medication must enroll in to make sure it's safe for you
    Cons
    •Must be given by a healthcare professional in a healthcare setting
    •Infusions take about an hour
    •Raises your risk for serious infection
    •Only FDA approved for adults

  • Common Side Effects of Mayzent vs. Tysabri

    Common Side Effects for
    •Headache (15%)
    •High blood pressure (13%)
    •Higher liver enzyme levels in the blood (11%)
    •Falls (11%)
    •Swelling of the arms and legs (edema, 8%)
    •Nausea (7%)
    •Dizziness (7%)
    •Diarrhea (6%)
    •Low heart rate (6%)
    •Pain in arms or legs (6%)
    Common Side Effects for
    •Headache (38%)
    •Fatigue or feeling extremely tired (27%)
    •Urinary tract infection (21%)
    •Joint pain (19%)
    •Depression (19%)
    •Lower respiratory tract infection (17%)
    •Pain in arm or leg (16%)
    •Rash or other skin irritation (up to 12%)

  • Warnings of Mayzent vs. Tysabri

    Common Side Effects for
    •Infections
    •Eye problems
    •Slow heart rate
    •Breathing problems
    •Liver damage
    •Risk of skin cancer
    •Harm to unborn babies
    •Brain problem called posterior reversible encephalopathy syndrome (PRES)
    Common Side Effects for
    •Progressive multifocal leukoencephalopathy (PML)
    •Other infections
    •Liver problems
    •Allergic reaction or infusion reaction
    •Low platelet levels

  • Prices with our coupons for Mayzent vs. Tysabri

    Learn more about Mayzent
    Learn more about Tysabri

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