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Kesimpta vs. Tysabri

Kesimpta (ofatumumab) is an injectable medication for adults with relapsing forms of multiple sclerosis (MS). It works as a monoclonal antibody to help lessen MS flare-ups that come and go. Kesimpta (ofatumumab) is injected under the skin. You can use the Kesimpta prefilled syringes or Sensoready Pens to inject. After the first 3 weekly injections, you inject the medication once a month. Some common side effects include a higher risk of infections, pain or swelling at the injection site, and headache.

• Relapsing forms of multiple sclerosis (MS), including relapsing-remitting MS, clinically isolated syndrome, and secondary progressive MS

• Upper respiratory tract infections (39%)
• Reactions related to the injection (e.g., fever, chills, tiredness; 21%)
• Headache (13%)
• Reaction at the injection site (e.g., pain, redness, swelling; 11%)
• Urinary tract infection (10%)

• Risk of infections
• Injection reactions
• Lower antibody levels
• Harm to an unborn baby

Tysabri (natalizumab) treats relapsing forms of multiple sclerosis (MS) and moderate-to-severe Crohn's disease (CD) in adults. This medication is a monoclonal antibody that works as an integrin antagonist. It lowers the immune system's activity and lessens inflammation. Tysabri (natalizumab) is given by a healthcare professional as a once-monthly infusion through the vein (IV). Common side effects include headache and fatigue. Because of the risk for serious infection, your care team will help you enroll in the TOUCH Prescribing Program and review the medication's warnings before treatment starts.

• Relapsing forms of multiple sclerosis (MS)
• Moderate-to-severe Crohn's disease (CD) when other treatments haven't worked well

• Headache (38%)
• Fatigue or feeling extremely tired (27%)
• Urinary tract infection (21%)
• Joint pain (19%)
• Depression (19%)
• Lower respiratory tract infection (17%)
• Pain in arm or leg (16%)
• Rash or other skin irritation (up to 12%)

• Progressive multifocal leukoencephalopathy (PML)
• Other infections
• Liver problems
• Allergic reaction or infusion reaction
• Low platelet levels