Kesimpta vs. Tysabri for Multiple Sclerosis: Important Differences and Potential Risks.

Kesimpta

(ofatumumab)

Tysabri

(natalizumab)

Summary for Kesimpta

Prescription only

Kesimpta (ofatumumab) is an injectable medication for adults with relapsing forms of multiple sclerosis (MS). It works as a monoclonal antibody to help lessen MS flare-ups that come and go. Kesimpta (ofatumumab) is injected under the skin. You can use the Kesimpta prefilled syringes or Sensoready Pens to inject. After the first 3 weekly injections, you inject the medication once a month. Some common side effects include a higher risk of infections, pain or swelling at the injection site, and headache.

Indications for Kesimpta

Relapsing forms of multiple sclerosis (MS), including relapsing-remitting MS, clinically isolated syndrome, and secondary progressive MS

Pros and Cons for Kesimpta

Pros

Injections are once a month (after the first 3 injections)
Can inject at home after you're trained
Comes as prefilled syringes and Sensoready Pens
Can be kept at room temperature for up to 7 days

Cons

Doesn't cure MS
Must give as an injection under the skin
Raises your risk of infections
Not recommended for people who are pregnant

Common Side Effects for Kesimpta

Upper respiratory tract infections (39%)
Reactions related to the injection (e.g., fever, chills, tiredness; 21%)
Headache (13%)
Reaction at the injection site (e.g., pain, redness, swelling; 11%)
Urinary tract infection (10%)

Warnings for Kesimpta

Risk of infections
Injection reactions
Lower antibody levels
Harm to an unborn baby

Summary for Tysabri

Prescription only

Tysabri (natalizumab) is an injectable medication used to treat relapsing forms of multiple sclerosis (MS) in adults. It can also treat moderate-to-severe Crohn's disease (CD) in adults. It works as an integrin antagonist to help lower inflammation in the body. Tysabri (natalizumab) is given by a healthcare professional as an infusion into a vein once a month. Common side effects include headache and fatigue. Because it has a risk of serious infections, you must enroll in the Tysabri TOUCH Program before starting treatment.

Indications for Tysabri

Relapsing forms of multiple sclerosis (MS)
Moderate-to-severe Crohn's disease (CD) when other treatments haven't worked well

Pros and Cons for Tysabri

Pros

Infusions are once every month
Can help reduce relapses in MS
An option for Crohn's disease when other treatments haven't worked well

Cons

Must be given by a healthcare professional in a healthcare setting
Raises your risk of serious infection
Only FDA approved for adults

Common Side Effects for Tysabri

Headache (38%)
Fatigue or feeling very tired (27%)
Urinary tract infection (21%)
Joint pain (19%)
Depression (19%)
Lower respiratory tract infection (17%)
Pain in arm or leg (16%)
Rash or other skin irritation (up to 12%)
Stomach discomfort (11%)
Diarrhea (10%)

Warnings for Tysabri

Risk of a brain infection leading to progressive multifocal leukoencephalopathy (PML)
Risk of other infections
Liver problems
Allergic reaction or infusion reaction
Low platelet levels
Other lab changes

Prices with our coupons for Kesimpta vs. Tysabri

Kesimpta1 pen / 20mg/0.4ml

$10,789.78-

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Tysabri1 vial / 15ml of 300mg/15ml

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Kesimpta vs. Tysabri

Kesimpta

Tysabri

Summary for Kesimpta

Indications for Kesimpta

Pros and Cons for Kesimpta

Pros

Cons

Common Side Effects for Kesimpta

Warnings for Kesimpta

Summary for Tysabri

Indications for Tysabri

Pros and Cons for Tysabri

Pros

Cons

Common Side Effects for Tysabri

Warnings for Tysabri

Prices with our coupons for Kesimpta vs. Tysabri

Compare other Multiple Sclerosis drugs

Browse medications by letter

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Kesimpta

Tysabri

Summary for Kesimpta

Indications for Kesimpta

Pros and Cons for Kesimpta

Pros

Cons

Common Side Effects for Kesimpta

Warnings for Kesimpta

Summary for Tysabri

Indications for Tysabri

Pros and Cons for Tysabri

Pros

Cons

Common Side Effects for Tysabri

Warnings for Tysabri