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Compare Kesimpta vs. Tysabri

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Kesimpta (ofatumumab)
    Tysabri (natalizumab)
  • Kesimpta (ofatumumab)
    Tysabri (natalizumab)

  • Summary of Kesimpta vs. Tysabri

    Summary for Monoclonal antibody
    Prescription only

    Kesimpta (ofatumumab) is an injectable medication for adults with relapsing forms of multiple sclerosis (MS). It works as a monoclonal antibody to help lessen MS flare-ups that come and go. Kesimpta (ofatumumab) is injected under the skin. You can use the Kesimpta prefilled syringes or Sensoready Pens to inject. After the first 3 weekly injections, you inject the medication once a month. Some common side effects include a higher risk of infections, pain or swelling at the injection site, and headache.

    Summary for Integrin receptor antagonist
    Prescription only

    Tysabri (natalizumab) treats relapsing forms of multiple sclerosis (MS) and moderate-to-severe Crohn's disease (CD) in adults. This medication is a monoclonal antibody that works as an integrin antagonist. It lowers the immune system's activity and lessens inflammation. Tysabri (natalizumab) is given by a healthcare professional as a once-monthly infusion through the vein (IV). Common side effects include headache and fatigue. Because of the risk for serious infection, your care team will help you enroll in the TOUCH Prescribing Program and review the medication's warnings before treatment starts.

  • Indications of Kesimpta vs. Tysabri

    Indications for
    •Relapsing forms of multiple sclerosis (MS), including relapsing-remitting MS, clinically isolated syndrome, and secondary progressive MS
    Indications for
    •Relapsing forms of multiple sclerosis (MS)
    •Moderate-to-severe Crohn's disease (CD) when other treatments haven't worked well

  • Pros and Cons of Kesimpta vs. Tysabri

    Pros and Const for Monoclonal antibody
    Pros
    •Injections are once a month (after the first 3 injections)
    •Can inject at home after you're trained
    •Comes as prefilled syringes and Sensoready Pens
    •Can be kept at room temperature for up to 7 days
    Cons
    •Doesn't cure MS
    •Must give as an injection under the skin
    •Raises your risk of infections
    •Not recommended for people who are pregnant
    Pros and Const for Integrin receptor antagonist
    Pros
    •Infusions are once every month
    •Can be used for CD or MS
    •Has a risk monitoring program that anyone who prescribes, dispenses, infuses, or receives the medication must enroll in to make sure it's safe for you
    Cons
    •Must be given by a healthcare professional in a healthcare setting
    •Infusions take about an hour
    •Raises your risk for serious infection
    •Only FDA approved for adults

  • Common Side Effects of Kesimpta vs. Tysabri

    Common Side Effects for
    •Upper respiratory tract infections (39%)
    •Reactions related to the injection (e.g., fever, chills, tiredness; 21%)
    •Headache (13%)
    •Reaction at the injection site (e.g., pain, redness, swelling; 11%)
    •Urinary tract infection (10%)
    Common Side Effects for
    •Headache (38%)
    •Fatigue or feeling extremely tired (27%)
    •Urinary tract infection (21%)
    •Joint pain (19%)
    •Depression (19%)
    •Lower respiratory tract infection (17%)
    •Pain in arm or leg (16%)
    •Rash or other skin irritation (up to 12%)

  • Warnings of Kesimpta vs. Tysabri

    Common Side Effects for
    •Risk of infections
    •Injection reactions
    •Lower antibody levels
    •Harm to an unborn baby
    Common Side Effects for
    •Progressive multifocal leukoencephalopathy (PML)
    •Other infections
    •Liver problems
    •Allergic reaction or infusion reaction
    •Low platelet levels

  • Prices with our coupons for Kesimpta vs. Tysabri

    Learn more about Kesimpta
    Learn more about Tysabri

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