Key takeaways
Plegridy (peginterferon beta-1a) and dimethyl fumarate (Tecfidera) are both used to treat relapsing forms of multiple sclerosis (MS), but they have some key differences. Plegridy is an injectable medication given every two weeks, while Tecfidera is an oral capsule taken twice a day. Plegridy belongs to the biologic drug class called interferon beta, whereas Tecfidera is a fumaric acid derivative. Both medications can cause liver damage and changes in blood counts, requiring regular blood tests. Additionally, Plegridy can also cause depression and heart problems, whereas dimethyl fumarate can cause flushing and serious stomach issues. Tecfidera is available as a lower-cost generic, while Plegridy does not have a generic form.
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