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Compare Vumerity vs. Tysabri

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Vumerity (diroximel fumarate) and Tysabri (natalizumab) are both used to treat relapsing forms of multiple sclerosis (MS), but they have some key differences. Vumerity is a fumaric acid derivative taken orally twice a day, while Tysabri is a monoclonal antibody given as an IV infusion once a month. Tysabri can also be used to treat Crohn’s disease that hasn’t responded well to other treatments. Both medications are thought to work by reducing inflammation. Tysabri requires enrollment in the TOUCH Prescribing Program due to its risk of serious infections like progressive multifocal leukoencephalopathy (PML). Vumerity can also cause serious side effects like liver damage, infections, and severe allergic reactions. Both medications can be expensive as they are only available as a brand-name forms.

  • Vumerity (diroximel fumarate)
    Tysabri (natalizumab)
  • Vumerity (diroximel fumarate)
    Tysabri (natalizumab)

  • Summary of Vumerity vs. Tysabri

    Summary for Fumaric acid derivative
    Prescription only

    Vumerity, also known by its generic name dimethyl fumarate, is approved in adults for treating relapsing forms of multiple sclerosis (MS). It belongs to the drug class called fumaric acid derivatives. Vumerity (diroximel fumarate) is a capsule that's taken by mouth twice per day. The most common side effects are stomach upset and flushing (e.g., facial warmth, redness, burning sensation).

    Summary for Integrin receptor antagonist
    Prescription only

    Tysabri (natalizumab) treats relapsing forms of multiple sclerosis (MS) and moderate-to-severe Crohn's disease (CD) in adults. This medication is a monoclonal antibody that works as an integrin antagonist. It lowers the immune system's activity and lessens inflammation. Tysabri (natalizumab) is given by a healthcare professional as a once-monthly infusion through the vein (IV). Common side effects include headache and fatigue. Because of the risk for serious infection, your care team will help you enroll in the TOUCH Prescribing Program and review the medication's warnings before treatment starts.

  • Indications of Vumerity vs. Tysabri

    Indications for
    •Relapsing forms of multiple sclerosis (MS)
    Indications for
    •Relapsing forms of multiple sclerosis (MS)
    •Moderate-to-severe Crohn's disease (CD) when other treatments haven't worked well

  • Pros and Cons of Vumerity vs. Tysabri

    Pros and Const for Fumaric acid derivative
    Pros
    •Lessens the number of relapses per year
    •Available in a "starter dose" bottle and "maintenance dose" bottle to help you keep track of how much medication to take
    •Few interactions with other medications
    Cons
    •Have to take twice per day
    •Flushing is a common side effect
    •Shouldn't take the medication with high-fat and high-calorie meals
    Pros and Const for Integrin receptor antagonist
    Pros
    •Infusions are once every month
    •Can be used for CD or MS
    •Has a risk monitoring program that anyone who prescribes, dispenses, infuses, or receives the medication must enroll in to make sure it's safe for you
    Cons
    •Must be given by a healthcare professional in a healthcare setting
    •Infusions take about an hour
    •Raises your risk for serious infection
    •Only FDA approved for adults

  • Common Side Effects of Vumerity vs. Tysabri

    Common Side Effects for
    •Flushing (40%)
    •Stomach pain (18%)
    •Diarrhea (14%)
    •Nausea (12%)
    Common Side Effects for
    •Headache (38%)
    •Fatigue or feeling extremely tired (27%)
    •Urinary tract infection (21%)
    •Joint pain (19%)
    •Depression (19%)
    •Lower respiratory tract infection (17%)
    •Pain in arm or leg (16%)
    •Rash or other skin irritation (up to 12%)

  • Warnings of Vumerity vs. Tysabri

    Common Side Effects for
    •Severe allergic reaction
    •Flushing
    •Risk for serious infections
    •Low white blood cell counts (lymphopenia)
    •Liver damage
    •Serious stomach and gut problems
    Common Side Effects for
    •Progressive multifocal leukoencephalopathy (PML)
    •Other infections
    •Liver problems
    •Allergic reaction or infusion reaction
    •Low platelet levels

  • Prices with our coupons for Vumerity vs. Tysabri

    Learn more about Vumerity
    Learn more about Tysabri

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