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Compare Mayzent vs. Plegridy

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Mayzent (siponimod) and Plegridy (peginterferon beta-1a) are both used to treat relapsing forms of multiple sclerosis (MS) in adults, but they have some key differences. Mayzent is taken orally once a day, while Plegridy is an injection given every two weeks. Mayzent works by blocking white blood cells from leaving the lymph nodes, which helps reduce nerve damage, whereas Plegridy calms down the immune system to prevent it from attacking the nervous system. Mayzent requires genetic testing before starting treatment to determine the correct dose, but Plegridy does not. Common side effects of Mayzent include headache and high blood pressure, while Plegridy often cause injection site reaction and flu-like symptoms. Both medications are only available as brand names.

  • Mayzent (siponimod)
    Plegridy (peginterferon beta-1a)
  • Mayzent (siponimod)
    Plegridy (peginterferon beta-1a)

  • Summary of Mayzent vs. Plegridy

    Summary for Sphingosine 1-phosphate receptor modulator
    Prescription only

    Mayzent (siponimod) is a disease-modifying treatment option for relapsing multiple sclerosis (MS) in adults. It can lower the chances of worsening MS and lower the number of MS relapses. Mayzent (siponimod) is a tablet that's taken by mouth. Common side effects include headache, high blood pressure, and falls. Mayzent (siponimod) is currently available as a brand-name only.

    Summary for Biologic
    Prescription only

    Plegridy (peginterferon beta-1a) is an interferon beta. It's used to treat relapsing forms of multiple sclerosis (MS) in adults. It's given either as an injection under the skin or into the muscle once every 2 weeks. Some of the more common side effects of Plegridy (peginterferon beta-1a) include redness at the injection site and flu-like symptoms. Though rare, it can also cause more serious side effects like depression and liver damage, so it's best to avoid drinking alcohol while taking Plegridy (peginterferon beta-1a).

  • Indications of Mayzent vs. Plegridy

    Indications for
    •Relapsing forms of multiple sclerosis (MS)
    Indications for
    •Relapsing forms of multiple sclerosis (MS)

  • Pros and Cons of Mayzent vs. Plegridy

    Pros and Const for Sphingosine 1-phosphate receptor modulator
    Pros
    •Works well to slow worsening of MS and lower the number of MS relapses
    •Taken by mouth once per day
    •Doesn't require frequent visits to the clinic or infusion center to receive your dose
    Cons
    •Requires several tests before starting (e.g., genetic testing, electrocardiogram, blood tests)
    •Might not be a good option for people with heart or serious liver problems
    •Not safe during pregnancy
    Pros and Const for Biologic
    Pros
    •Works well as a disease-modifying therapy (DMT) to treat relapsing forms of MS
    •Only has to be injected every 14 days
    •Can be kept at room temperature for up to 30 days, which can be convenient if you're traveling
    Cons
    •Might be difficult for some people to administer correctly
    •Can potentially cause a lot of serious side effects like liver damage and mental health problems
    •It's not completely known if Plegridy (peginterferon beta-1a) is safe in pregnant or breastfeeding women

  • Common Side Effects of Mayzent vs. Plegridy

    Common Side Effects for
    •Headache (15%)
    •High blood pressure (13%)
    •Higher liver enzyme levels in the blood (11%)
    •Falls (11%)
    •Swelling of the arms and legs (edema, 8%)
    •Nausea (7%)
    •Dizziness (7%)
    •Diarrhea (6%)
    •Low heart rate (6%)
    •Pain in arms or legs (6%)
    Common Side Effects for
    •Injection-site redness (62%)
    •Flu-like symptoms (47%)
    •Fever (45%)
    •Headache (44%)
    •Muscle pain (19%)
    •Chills (17%)
    •Injection-site pain and itching (up to 15%)
    •Weakness (13%)
    •Joint pain (11%)

  • Warnings of Mayzent vs. Plegridy

    Common Side Effects for
    •Infections
    •Eye problems
    •Slow heart rate
    •Breathing problems
    •Liver damage
    •Risk of skin cancer
    •Harm to unborn babies
    •Brain problem called posterior reversible encephalopathy syndrome (PRES)
    Common Side Effects for
    •Liver damage
    •Depression and suicide
    •Severe allergic and injection-site reactions
    •Congestive heart failure
    •Lower blood cell counts
    •High blood pressure in the lungs
    •Autoimmune problems
    •Seizures

  • Prices with our coupons for Mayzent vs. Plegridy

    Learn more about Mayzent
    Learn more about Plegridy

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