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Compare Mayzent vs. Lemtrada

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Mayzent (siponimod) and Lemtrada (alemtuzumab) are both used to treat relapsing forms of multiple sclerosis (MS), but they have several key differences. Mayzent is taken orally as a daily tablet, while Lemtrada is given as an annual infusion by a healthcare provider. Mayzent requires genetic testing before starting treatment to determine the appropriate dose, whereas Lemtrada is typically reserved for those who haven't responded well to at least two other MS medications. Lemtrada has a higher risk profile, including serious autoimmune problems, infusion reactions, and a need for ongoing monitoring through a REMS program. In contrast, Mayzent's common side effects include headache and high blood pressure, and it also requires monitoring but not through a specialized program. Additionally, Both medications are available as brand name only and they both are not safe during pregnancy and require birth control measures during and after treatment.

  • Mayzent (siponimod)
    Lemtrada (alemtuzumab)
  • Mayzent (siponimod)
    Lemtrada (alemtuzumab)

  • Summary of Mayzent vs. Lemtrada

    Summary for Sphingosine 1-phosphate receptor modulator
    Prescription only

    Mayzent (siponimod) is a disease-modifying treatment option for relapsing multiple sclerosis (MS) in adults. It can lower the chances of worsening MS and lower the number of MS relapses. Mayzent (siponimod) is a tablet that's taken by mouth. Common side effects include headache, high blood pressure, and falls. Mayzent (siponimod) is currently available as a brand-name only.

    Summary for Anti-CD52 monoclonal antibody
    Prescription only

    Lemtrada (alemtuzumab) is an anti-CD52 monoclonal antibody. It's used to treat relapsing forms of multiple sclerosis (MS) in adults, but only when other MS medications haven't worked well. Lemtrada (alemtuzumab) is given as an infusion through the veins once per year by a healthcare provider. Since this medication has many risks and side effects, it's only available through a Risk Evaluation and Mitigation Strategy (REMS) program) called the Lemtrada REMS program. Some common side effects of Lemtrada (alemtuzumab) include rash, headache, and fever.

  • Indications of Mayzent vs. Lemtrada

    Indications for
    •Relapsing forms of multiple sclerosis (MS)
    Indications for
    •Relapsing forms of multiple sclerosis (MS) in adults who haven't responded well enough to at least two other MS medications

  • Pros and Cons of Mayzent vs. Lemtrada

    Pros and Const for Sphingosine 1-phosphate receptor modulator
    Pros
    •Works well to slow worsening of MS and lower the number of MS relapses
    •Taken by mouth once per day
    •Doesn't require frequent visits to the clinic or infusion center to receive your dose
    Cons
    •Requires several tests before starting (e.g., genetic testing, electrocardiogram, blood tests)
    •Might not be a good option for people with heart or serious liver problems
    •Not safe during pregnancy
    Pros and Const for Anti-CD52 monoclonal antibody
    Pros
    •Works well to treat relapsing forms of MS
    •Treatment courses are short and are only once per year
    •Not many known interactions with other medications
    Cons
    •A lot of potential risks and side effects, including serious allergic reaction, blood problems, and liver problems
    •Each treatment will take a least 6 hours at the clinic because of pre-treatment, infusion time, and monitoring time
    •Needs to be given as an IV injection by a healthcare professional

  • Common Side Effects of Mayzent vs. Lemtrada

    Common Side Effects for
    •Headache (15%)
    •High blood pressure (13%)
    •Higher liver enzyme levels in the blood (11%)
    •Falls (11%)
    •Swelling of the arms and legs (edema, 8%)
    •Nausea (7%)
    •Dizziness (7%)
    •Diarrhea (6%)
    •Low heart rate (6%)
    •Pain in arms or legs (6%)
    Common Side Effects for
    •Rash (53%)
    •Headache (52%)
    •Fever (29%)
    •Sore throat, runny nose (25%)
    •Nausea (21%)
    •Urinary tract infection (19%)
    •Tiredness (18%)
    •Difficulty sleeping (16%)
    •Upper respiratory tract infection (16%)
    •Herpes viral infection (16%)
    •Hives (16%)

  • Warnings of Mayzent vs. Lemtrada

    Common Side Effects for
    •Infections
    •Eye problems
    •Slow heart rate
    •Breathing problems
    •Liver damage
    •Risk of skin cancer
    •Harm to unborn babies
    •Brain problem called posterior reversible encephalopathy syndrome (PRES)
    Common Side Effects for
    •Lemtrada REMS program
    •Autoimmune problems
    •Severe allergy and infusion reactions
    •Stroke
    •Risk of cancers
    •Inflammatory problems
    •Serious infections

  • Prices with our coupons for Mayzent vs. Lemtrada

    Learn more about Mayzent
    Learn more about Lemtrada

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