Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Entocort vs. Tysabri

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Budesonide (Entocort EC) and natalizumab (Tysabri) are both used to treat Crohn's disease, but they belong to different medication classes. Budesonide is a corticosteroid that helps reduce inflammation in the intestines, while natalizumab is an integrin antagonist that may work by blocking signals that cause inflammation. Budesonide is taken orally as a capsule once daily, whereas natalizumab is given as a monthly intravenous (IV) infusion by a healthcare professional. Budesonide is available as a generic, making it a more cost-effective option, while natalizumab is only available as a brand-name medication. Common side effects of budesonide include headache and respiratory infections, while natalizumab can cause headaches and fatigue. Both medications can increase the risk of infections, but natalizumab has a higher risk of serious infections, including a rare brain infection called progressive multifocal leukoencephalopathy (PML). Additionally, natalizumab requires enrollment in a special monitoring program due to its risks.

  • Budesonide
    Tysabri (natalizumab)
  • Budesonide
    Tysabri (natalizumab)

  • Summary of Entocort vs. Tysabri

    Summary for Corticosteroid
    Prescription only

    Budesonide is a corticosteroid that's used to treat mild-to-moderate Crohn's disease in adults and children. It's available as capsules that are taken by mouth once daily. The most common side effects are headache and respirator infections. More rarely, it might cause weight gain too.

    Summary for Integrin receptor antagonist
    Prescription only

    Tysabri (natalizumab) treats relapsing forms of multiple sclerosis (MS) and moderate-to-severe Crohn's disease (CD) in adults. This medication is a monoclonal antibody that works as an integrin antagonist. It lowers the immune system's activity and lessens inflammation. Tysabri (natalizumab) is given by a healthcare professional as a once-monthly infusion through the vein (IV). Common side effects include headache and fatigue. Because of the risk for serious infection, your care team will help you enroll in the TOUCH Prescribing Program and review the medication's warnings before treatment starts.

  • Indications of Entocort vs. Tysabri

    Indications for
    •Mild-to-moderate active Crohn's disease in people ages 8 years and older
    •Maintenance of remission of Crohn's disease in adults
    Indications for
    •Relapsing forms of multiple sclerosis (MS)
    •Moderate-to-severe Crohn's disease (CD) when other treatments haven't worked well

  • Pros and Cons of Entocort vs. Tysabri

    Pros and Const for Corticosteroid
    Pros
    •Works where you have symptoms in your intestines (gut)
    •Might cause fewer side effects than other steroids
    •Taken once a day
    •Available as a lower-cost generic
    Cons
    •Not recommended for long-term use
    •Might not work as well as other steroids like prednisone
    •Can raise your risk for infections
    •Can take a couple months to see full benefit from the medication
    Pros and Const for Integrin receptor antagonist
    Pros
    •Infusions are once every month
    •Can be used for CD or MS
    •Has a risk monitoring program that anyone who prescribes, dispenses, infuses, or receives the medication must enroll in to make sure it's safe for you
    Cons
    •Must be given by a healthcare professional in a healthcare setting
    •Infusions take about an hour
    •Raises your risk for serious infection
    •Only FDA approved for adults

  • Common Side Effects of Entocort vs. Tysabri

    Common Side Effects for

    Treatment of active, mild-to-moderate Crohn’s disease:

    •Headache (21%)
    •Infection in your air passageway (respiratory infection; 11%)
    •Nausea (11%)
    •Back pain (7%)
    •Dizziness (7%)
    •Upset stomach or indigestion (6%)
    •Gas (6%)
    •Stomach pain (6%)
    •Vomiting (6%)
    •Feeling tired (5%)
    •Pain (5%)

    Maintenance of remission of Crohn’s disease**:

    •Diarrhea (10%)
    •Sinus inflammation (8%)
    •Viral infection (6%)
    •Joint pain (5%)

    ** Side effects listed are in addition to those observed with treatment of active Crohn's disease.

    Common Side Effects for
    •Headache (38%)
    •Fatigue or feeling extremely tired (27%)
    •Urinary tract infection (21%)
    •Joint pain (19%)
    •Depression (19%)
    •Lower respiratory tract infection (17%)
    •Pain in arm or leg (16%)
    •Rash or other skin irritation (up to 12%)

  • Warnings of Entocort vs. Tysabri

    Common Side Effects for
    •Changes in stress hormone levels in the body
    •Higher risk of infections
    •Worsening of certain medical conditions
    Common Side Effects for
    •Progressive multifocal leukoencephalopathy (PML)
    •Other infections
    •Liver problems
    •Allergic reaction or infusion reaction
    •Low platelet levels

  • Prices with our coupons for Entocort vs. Tysabri

    Learn more about Budesonide
    Learn more about Tysabri

Compare other Crohn's Disease drugs

Entyvio vs OrtikosOrtikos vs AzasanOrtikos vs ImuranOrtikos vs RemicadeOrtikos vs StelaraOrtikos vs TrexallOrtikos vs TysabriCromolyn vs ImuranEntyvio vs HumiraEntyvio vs RinvoqEntyvio vs SkyriziEntyvio vs StelaraImuran vs AzulfidineImuran vs PrednisoneImuran vs PrografImuran vs RapamuneImuran vs RemicadeImuran vs TrexallInflectra vs EntyvioMyfortic vs ImuranOrencia vs RemicadePrednisone vs RemicadeRemicade vs CimziaRemicade vs EntyvioRemicade vs HumiraRemicade vs RinvoqRemicade vs SimponiRituxan vs RemicadeTremfya vs EntyvioZeposia vs Entyvio
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.