Key takeaways
Azathioprine (Imuran) and sirolimus (Rapamune) are both immunosuppressants used to prevent kidney transplant rejection, but they have some key differences. Azathioprine is also used to treat rheumatoid arthritis, while sirolimus is used for a condition called lymphangioleiomyomatosis (LAM). Azathioprine can be taken orally or via IV, whereas sirolimus is only available in oral form, including tablets and an oral solution. Azathioprine requires regular blood tests to monitor for side effects like liver damage and low blood cell counts, while sirolimus also needs blood level monitoring due to risks like high cholesterol and kidney damage. Both medications can increase the risk of infections and certain cancers, but sirolimus is not recommended for liver and lung transplants due to higher risks of serious complications. Additionally, sirolimus can affect fertility and is not suitable for children under 13, while azathioprine is noted for its potential to cause birth defects, requiring contraception for both men and women. Both medications are available in generic forms, making them more affordable.
