Key takeaways
Indocin (indomethacin) and prednisone are both prescription medications used to treat inflammation, but they belong to different drug classes and work in different ways. Indocin is a nonsteroidal anti-inflammatory drug (NSAID) that helps reduce inflammation and pain by blocking proteins called cyclooxygenase (COX). It's available as a tablet, liquid, and rectal suppository, which can be a good option if you have trouble swallowing pills. Prednisone, on the other hand, is a corticosteroid that mimics a natural hormone in your body to calm down your immune response. It's taken orally and is available in various forms, including tablets and liquid. While Indocin is typically used for arthritis and shoulder pain, prednisone treats a wider range of conditions, including allergies, skin conditions, and certain cancers. Both medications have serious side effects, but prednisone can also cause long-term issues like weakened bones and a higher risk of infections if used for a long time. Indocin is not recommended during pregnancy, especially after 20 weeks, while prednisone requires careful monitoring if you're pregnant or planning to become pregnant.
