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Naproxen vs. Indocin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Naproxen (Naprosyn) and indomethacin (Indocin) are both NSAIDs used to treat pain and inflammation, but they have some key differences. Naproxen is available in both prescription and over-the-counter forms, while indomethacin requires a prescription. Naproxen can be taken orally as a tablet or liquid suspension, whereas indomethacin is available as a rectal suppository or oral tablet. Naproxen is typically taken 2 to 3 times a day, while indomethacin might need to be used 2 to 4 times a day. Common side effects of both medications include headache, heartburn, and stomach pain. Additionally, neither medication isrecommended after 20 weeks of pregnancy due to risks to the unborn baby. Both medications can cause serious side effects like stomach bleeding and heart problems, so it's important to follow your prescriber's instructions carefully.

Naproxen

(Naprosyn)

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Indomethacin

(Indocin)

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Summary for Naproxen

Prescription only

Prescription-strength naproxen (Naprosyn) is a non-steroidal anti-inflammatory drug (NSAID). It can be taken by adults and children to relieve pain and symptoms of certain conditions that cause inflammation, such as rheumatoid arthritis, osteoarthritis, or gout. Naproxen (Naprosyn) works by blocking specific proteins that cause inflammation and pain. Naproxen (Naprosyn) comes as tablet and liquid suspension that are taken by mouth, typically 2 to 3 times per day. Some common side effects include heartburn, stomach pain, and nausea.

Indications for Naproxen

Pros and Cons for Naproxen

Pros

  • Works well for treating pain and inflammation
  • Effects last longer than other NSAIDs, such as ibuprofen (Advil)
  • Available as a liquid for people who have a hard time swallowing pills

Cons

  • Can cause stomach bleeding or stomach ulcers
  • Not safe to take after 20 weeks of pregnancy
  • Might not be the best option if you're 65 years or older, or have kidney, heart, liver, or bleeding problems

Common Side Effects for Naproxen

The following side effects were reported in 3-9% of people in clinical studies:

  • Heartburn
  • Stomach pain
  • Constipation
  • Nausea
  • Dizziness
  • Drowsiness
  • Headache
  • Itchy skin
  • Bruising
  • Ringing in the ears
  • Swelling
  • Shortness of breath

Warnings for Naproxen

  • Stomach bleeding
  • Heart attack and stroke
  • High blood pressure and heart failure
  • Kidney damage
  • Liver problems
  • Severe allergic reactions
  • Not for use in pregnant or breastfeeding females

Summary for Indocin

Prescription only

Indomethacin (Indocin) is an NSAID that's used to treat different types of arthritis, including arthritis related to gout. It's also used to treat conditions that cause shoulder pain. This medication can be used in people 15 years of age and older; it hasn't been studied in younger children. The oral form of indomethacin (Indocin) is available as capsules (both immediate-release and extended-release) and a liquid. The dosage for immediate-release formulations is typically 2 to 4 times a day, and the dosage for extended-release capsules is once a day. Common side effects include headache, dizziness, and stomach upset.

Indications for Indocin

Pros and Cons for Indocin

Pros

  • Can relieve pain and swelling
  • Available in fast-acting formulations and a longer-acting, extended-release capsule
  • Dose can be adjusted by your provider if needed
  • Liquid version is a good option for people who have trouble swallowing pills

Cons

  • Might not be the best option for long-term use because of safety risks
  • Most forms are taken 2 to 4 times a day
  • Not a good choice if you have kidney or liver problems
  • Can raise your risk of blood clots, heart attack, or stroke (similar to other NSAIDs)

Common Side Effects for Indocin

Note: Side effects listed here are for immediate-release indomethacin. Side effects for extended-release capsules might differ.

  • Headache (12%)
  • Nausea (up to 9%)
  • Upset stomach (up to 9%)
  • Dizziness (up to 9%)

Warnings for Indocin

  • Stomach bleeding and ulcers
  • Heart attack and stroke
  • High blood pressure and heart failure
  • Liver problems
  • Kidney damage and high potassium levels
  • Severe allergic reactions
  • Severe asthma attack
  • Worsening of nervous system and mental health problems
  • Harm to unborn babies

Prices with our coupons for Naproxen vs. Indocin

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Naproxen20 tablets / 500mg
$10.61$11.94
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Price Card Drug Icon
Indomethacin1 vial / 1mg
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