Key takeaways
Nabumetone (Relafen) and naproxen (Naprosyn) are both nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat pain and inflammation, but they have some differences. Nabumetone is typically taken once or twice a day, while naproxen is usually taken twice per day. Nabumetone is known to cause fewer stomach-related side effects compared to naproxen, but both medications can cause stomach bleeding and ulcers. Naproxen is available in both prescription and over-the-counter forms, whereas nabumetone is only available by prescription. Neither medication is recommended for people with severe heart failure or during late pregnancy. Both medications can cause serious side effects like heart attack, stroke, and kidney problems, but naproxen has a broader range of uses, including treating gout and menstrual cramps.
