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Nabumetone Coupon - Nabumetone 500mg tablet

nabumetone

Generic Relafen
Used for Rheumatoid Arthritis, Osteoarthritis
Used for Rheumatoid Arthritis, Osteoarthritis

Nabumetone is a prescription nonsteroidal anti-inflammatory drug (NSAID). It works to help relieve symptoms of rheumatoid arthritis and osteoarthritis in adults. This can include pain, swelling, and stiffness in your joints. Nabumetone is a tablet that you take by mouth typically once per day. The dosage can be adjusted based on how well the medication is working for you. Side effects can include diarrhea and upset stomach.

Last reviewed on November 7, 2025
basics-icon

What is Nabumetone?

What is Nabumetone used for?

How Nabumetone works

Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking proteins in the body called cyclooxygenase (COX). These proteins play a role in causing inflammation from rheumatoid arthritis and osteoarthritis.

By blocking COX, nabumetone helps relieve pain, swelling, stiffness, and other arthritis symptoms.

When does Nabumetone start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsRelafen DS
Drug ClassNSAID
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only

More on Nabumetone essentials

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What are the side effects of Nabumetone?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diarrhea (14%)
  • Indigestion (13%)
  • Stomach pain (12%)
  • Constipation (up to 9%)
  • Gas (up to 9%)
  • Nausea (up to 9%)
  • Dizziness (up to 9%)
  • Headache (up to 9%)
  • Itching (up to 9%)
  • Rash (up to 9%)
  • Ringing in the ears (up to 9%)
  • Swelling (up to 9%)

Other Side Effects

  • Vomiting
  • Fatigue
  • Sleepiness
  • Trouble sleeping
  • Nervousness

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Stomach ulcer: gnawing pain in the stomach, acid reflux, feel full quickly
  • Stomach bleeding: feeling faint, vomiting blood, bloody or dark stools, severe stomach pain or discomfort
  • Heart attack: chest pain or tightness; pain that spreads to your shoulder, arm, neck, or jaw; sweating
  • Stroke: chest pain, trouble breathing, weakness in one part of your body or face, blurred vision, slurred speech, severe headache
  • Heart failure: trouble breathing, swelling, sudden weight gain, tiredness, dizziness
  • Kidney problems: urinating less than usual, foamy or bloody urine, muscle cramps, low appetite, tiredness, dry and itchy skin
  • Liver problems: swelling of your stomach, yellowing of your skin or the whites of your eyes, confusion, dark or brown urine
  • Serious allergic reaction: hives, rash, swelling of the face, swelling of the lips or tongue, trouble breathing, fever, swollen lymph nodes
  • Serious skin reactions: rash, skin reddening, blisters, peeling skin

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Headache

itching skin

nausea

rash

stomach pain

swelling

Less common

Burning feeling in chest or stomach

indigestion

stomach upset

swelling or inflammation of the mouth

tenderness in stomach area

vomiting

Rare

Bleeding gums

blistering, peeling, loosening of skin

bloody or black, tarry stools

bloody or cloudy urine

burning upper abdominal pain

changes in vision

chest pain

chills

clay-colored stools

constipation

cough

dark-colored urine

diarrhea

difficult or labored breathing

difficulty swallowing

dizziness

dry cough

dry mouth

fast heartbeat

fever

fluid-filled skin blisters

general feeling of tiredness or weakness

greatly decreased frequency of urination or amount of urine

high blood pressure

hives or welts

increased sensitivity of skin to sunlight

increased thirst

joint pain, stiffness, or swelling

large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs

light-colored stools

loss of appetite

muscle pain

pain in lower back or side

pinpoint red spots on skin

puffiness or swelling of the eyelids or around the eyes, face, lips or tongue

rapid breathing

red irritated eyes

red skin lesions, often with a purple center

redness or other discoloration of skin

severe or continuing stomach pain

severe sunburn

shortness of breath

skin thinness

sore throat

sores, ulcers, or white spots in mouth or on lips

stomach bloating, burning, or cramping

swelling of face, fingers, feet or lower legs

tightness in chest

unpleasant breath odor

unusual bleeding or bruising

unusual tiredness or weakness

vaginal bleeding

vomiting of blood or material that looks like coffee grounds

weight gain or loss

wheezing

yellow eyes or skin

Symptoms of overdose

Agitation

blurred vision

coma

confusion

depression

hostility

irregular, fast or slow, or shallow breathing

irritability

muscle twitching

nervousness

pain or discomfort in chest, upper stomach, or throat

pale or blue lips, fingernails, or skin

pounding in the ears

seizures

severe stomach pain

slow heartbeat

stupor

unusual drowsiness, dullness, or feeling of sluggishness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach

belching

bloated full feeling

continuing ringing or buzzing or other unexplained noise in ears

excess air or gas in stomach or intestines

hearing loss

indigestion

mild diarrhea

passing gas

Less common

Increased sweating

sleepiness or unusual drowsiness

sleeplessness

trouble sleeping

unable to sleep

Rare

Anxiety

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

feeling of constant movement of self or surroundings

general feeling of discomfort or illness

increased appetite

lack or loss of strength

lightheadedness

sensation of spinning

shakiness in legs, arms, hands, feet

trembling or shaking of hands or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Nabumetone

thumbs-up

Pros

Works well to help with OA and RA

Might have a lower risk of serious stomach issues than some other NSAIDs

Typically taken by mouth once per day

thumbs-down

Cons

Requires a prescription from a healthcare professional

Has many risks, including heart issues, stomach bleeding, and kidney problems

Not recommended for people with severe heart failure or kidney problems

pharmacist-tips

Pharmacist tips for Nabumetone

pharmacist
  • You can take nabumetone with or without food. But it could be a good idea to take it with food or milk. NSAIDs like nabumetone can upset the stomach, so taking it with food can help ease this side effect.

    • Avoid drinking alcohol while taking nabumetone. Alcohol can raise your risk of serious stomach problems, like stomach ulcers and bleeding. Speak to your care team about your drinking habits. If you need help cutting back on alcohol, talk to your care team. They can connect you with resources or help you find other options to manage your arthritis.

      • Nabumetone can raise the risk of stomach bleeding. Get medical help right away if you have severe stomach pain that doesn't get better or bloody vomit or stool. These could be signs of stomach bleeding, which should get treated as soon as possible.

        • Nabumetone might raise your blood pressure. Your prescriber might ask you to check your blood pressure at home, particularly if you already have high blood pressure. Let your prescriber know if it stays higher than usual. They might need to help you manage your blood pressure better.

          • Don't take nabumetone with other NSAIDs like ibuprofen (Advil) unless a healthcare professional says it's okay. Taking more than one NSAID can raise your risk of serious side effects like stomach bleeding. NSAIDs are common in over-the-counter pain and cold medications. Ask a healthcare professional or pharmacist if you're not sure you're already taking an NSAID.

            • Make sure to tell your prescriber and pharmacist about all of the medications you take or plan to take. Nabumetone can interact with a lot of medications, such as blood pressure medications and blood thinners (including aspirin). Some interactions can make your medications work less well. Others can raise your risk of side effects. Your care team can check that your medications are safe to take together and make changes if needed.

              • If you're allergic to aspirin, there's a chance you might be allergic to nabumetone too. Tell your prescriber about all your allergies.

                • If you're pregnant, talk to your care team about safer options. It's not clear how safe nabumetone is in early pregnancy. And the FDA recommends avoiding NSAIDs like nabumetone during the second half of pregnancy because they might harm your unborn baby.

                  • If you're breastfeeding, talk to your prescriber. They can help explain the risks and benefits of taking nabumetone. It's not clear if the medication can get into breast milk and if it can affect a nursing baby.

                    faqs

                    Frequently asked questions about Nabumetone

                    Is nabumetone discontinued?
                    No. Generic nabumetone is still available as 500 mg, 750 mg, and 1,000 mg tablets. Only the 1,000 mg tablets are available under the brand name Relafen DS. If you have questions about the medication's availability, talk to your pharmacist.
                    Is nabumetone a muscle relaxer?
                    No, nabumetone is not a muscle relaxer. This medication is known as an NSAID, or a nonsteroidal anti-inflammatory drug. Muscle relaxers and NSAIDs help with different kinds of pain. Muscle relaxers help with muscle pain, and NSAIDs relieve pain related to inflammation. In particular, nabumetone helps relieve symptoms of some types of arthritis. These symptoms include pain, swelling, and stiffness in joints.
                    Is nabumetone a narcotic?
                    No, nabumetone isn't a narcotic. The term "narcotic" refers to opioid medications. Nabumetone isn't an opioid. Rather, it's an NSAID, or a nonsteroidal anti-inflammatory drug.
                    How long does it take for nabumetone to kick in?
                    It can usually take up to a couple hours before you start feeling pain relief after taking a nonsteroidal anti-inflammatory drug (NSAID) like nabumetone. But it might take a few days to weeks of regular use before you feel overall improvement in your symptoms. It's a good idea to keep track of how you're feeling while taking this medication. If you have questions about how well nabumetone is working, talk to your prescriber.
                    What pain reliever can I take with nabumetone?
                    If you need more pain relief, it's usually safe to take acetaminophen (Tylenol) with nabumetone. But it might not be the best choice for everyone, especially if you have liver problems. Don't take other nonsteroidal anti-inflammatory drugs (NSAIDs) while taking nabumetone. This includes ibuprofen (Advil) and naproxen (Aleve). Nabumetone is also an NSAID. Taking more than one NSAID at the same time can raise your risk of serious side effects, such as heart, kidney, or bleeding problems. Talk to your prescriber or primary care provider if you're still in pain after starting nabumetone.
                    Can nabumetone cause bruising?
                    Yes, it's possible for nabumetone to cause bruising. Nonsteroidal anti-inflammatory drugs (NSAIDs) like nabumetone affect how well the platelets in your body work to make blood clots. This can raise your risk of easy bleeding and bruising. If you notice that you're bruising more easily than usual, tell your care team. If you bleed a lot from a cut or if bleeding doesn't stop after applying pressure, get medical help right away.
                    Does nabumetone cause drowsiness?
                    Some people can feel drowsy or sleepy after starting nabumetone, but it's not common. Keep in mind that some people also had trouble sleeping at night (insomnia). When you take this medication for the first time, pay attention to how it affects your sleep habits. If you feel too sleepy to go about your day or if it's making it hard to fall asleep, talk to your prescriber. They can check to see if the problem is caused by nabumetone or other things. If needed, they can recommend an alternative medication to help with your symptoms.
                    Does nabumetone cause weight gain?
                    It's not common, but some people reported weight gain while taking nabumetone. This medication can make your body hold onto extra water. This can cause swelling and weight gain as "water weight." If you notice unexpected weight gain after starting nabumetone, talk to your prescriber or primary care provider.
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                    warings-icon

                    What are the risks and warnings for Nabumetone?

                    Nabumetone can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                    risk-warning

                    Risk of stomach ulcers and stomach bleeding

                    • Risk factors: Older adults | History of peptic ulcer disease | History of stomach bleeding | Bleeding problems | Liver problems | Taking other medications that raise your risk of bleeds | Taking nabumetone for a long time | Drinking alcohol | Smoking

                      Nabumetone can raise your risk of stomach problems, like inflammation, stomach ulcers (sores), and bleeding. These problems can happen at any time while taking this medication. They can be serious and sometimes life-threatening and need treatment right away.

                      Let your prescriber and pharmacist know about your medical conditions and all the medications you take. They can check your risk for stomach ulcers and stomach bleeding from nabumetone.

                      Tell your care team if you have gnawing pain in the stomach, have acid reflux, or feel full quickly. These can be signs of a stomach ulcer.

                      People who have stomach bleeds often don't have any symptoms since the bleed can happen over time. But get medical help right away if you feel faint, have severe stomach pain that doesn't go away, vomit blood, or have bloody or dark stools. These can be signs of stomach bleeding.

                      risk-warning

                      Risk of heart attack and stroke

                      • Risk factors: Heart problems | Having risk factors for heart problems | Recent heart attack | Taking higher doses of nabumetone | Taking nabumetone for a long time | Recent or planned heart surgery

                        Nabumetone might raise your risk of blood clots, which can lead to a heart attack or stroke. If you have heart problems, including a recent heart attack, talk to your prescriber to make sure this medication is safe for you. Don't take nabumetone if you've had a recent heart surgery or if you will have one soon. Your risk is much higher right after surgery.

                        To lower your risk, take the lowest dose of nabumetone for the shortest time needed. Call 911 if you have signs of a heart attack, like chest pain that spreads to your arm or neck, shortness of breath, or sweating. Also, get medical help right away if you have a severe headache, weakness on one side of your body, a droopy face, or trouble speaking or walking. These can be signs of a stroke.

                        risk-warning

                        High blood pressure

                        Nabumetone can raise your blood pressure. Tell your prescriber if you have high blood pressure. Also let them know if you're taking any blood pressure medications. Nabumetone can make these medications work less well.

                        Check your blood pressure regularly at home. Talk to your primary care provider if your blood pressure stays higher than usual while taking nabumetone.

                        risk-warning

                        Swelling and risk of heart failure

                        • Risk factors: Heart problems

                          Nabumetone can cause your body to hold onto extra fluid. This can cause swelling in your legs or feet. Too much fluid buildup in the body can also put you at risk for heart failure.

                          Tell your prescriber if you have heart problems or heart failure. People with severe heart failure should only take nabumetone if the benefits are greater than the risks. Also let your prescriber know about any medications for heart problems because nabumetone can affect how well they work. Your prescriber can make sure this medication is safe for you.

                          Let your care team know if you notice swelling in your legs or ankles. Watch for other signs of heart failure like shortness of breath, chest pain with physical activity, sudden weight gain, and tiredness.

                          risk-warning

                          Kidney damage

                          • Risk factors: Older adults | Kidney problems | Liver problems | Heart failure | Taking diuretics (water pills) | Taking other medications that can harm the kidneys

                            Taking NSAIDs like nabumetone for a long time can harm your kidneys. Your risk is higher if you have certain health conditions like kidney problems or heart failure. It's also higher if you take other medications that can cause kidney damage, like diuretics (water pills).

                            If you're at risk for kidney damage, your prescriber might check your kidney health using a blood test. Call your care team if you notice a change in how often you urinate. Also let them know if you start to feel very tired or have muscle cramps. These can be signs of kidney problems. You might need to stop taking nabumetone if your kidneys get affected.

                            risk-warning

                            Liver problems

                            • Risk factors: History of liver problems

                              Some people taking NSAIDs like nabumetone can have higher liver enzyme levels in their blood. This can be a sign of liver damage. In rare cases, this damage has led to serious problems like liver failure.

                              Get medical help right away if you notice swelling of your stomach or pain in the upper right side of your stomach. Also get help if you see yellowing of your skin or eyes, changes in your stool (black, tarry, or bloody stools), or dark or brown urine. These can be signs of liver damage. You might need to stop taking nabumetone to prevent any more liver damage.

                              risk-warning

                              Risk of general bleeding and anemia

                              • Risk factors: Taking with blood thinners, like aspirin or warfarin | Blood-clotting problems

                                NSAIDs like nabumetone can raise your risk of bleeding. Be careful if you also take other medications that make bleeding more likely, such as blood thinners. Let a healthcare professional know if you notice that you bruise easily or if it takes longer for bleeding to stop while taking nabumetone.

                                Some people can also have anemia (low red blood cell count) while taking nabumetone. Tell your care team if you feel very weak, dizzy, or short of breath. These could be signs of anemia, and your care team can check to make sure everything is okay.

                                risk-warning

                                Severe allergic reactions and skin reactions

                                • Risk factors: Allergy to aspirin | Allergy to NSAIDs | Aspirin-sensitive asthma | Asthma with rhinitis (runny or stuffy nose), with or without nasal polyps

                                  Severe allergic reactions to nabumetone are possible. These reactions can be life-threatening and can include facial swelling and anaphylaxis. Don't take this medication if you're allergic to aspirin or other NSAIDs. You could also have an allergic reaction to nabumetone. Call 911 right away if you have hives, a swollen face, swollen lips or tongue, or trouble breathing after taking this medication.

                                  Rarely, nabumetone can also cause other serious reactions. They include Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). These reactions can cause rash, blisters, or skin peeling. Drug reaction with eosinophilia and systemic symptoms (DRESS) can happen with or without a rash. Stop taking nabumetone and get medical help as soon as possible if you have any unusual skin changes.

                                  risk-warning

                                  Not safe to take while pregnant

                                  Nabumetone can cause harm to an unborn baby, especially if it's taken in the second half of pregnancy (after week 20). It can raise the risk of serious health issues, like heart or kidney problems in your unborn baby.

                                  If you're pregnant, talk to your prescriber or obstetrician-gynecologist (OB-GYN) about the risks and benefits of taking nabumetone. Ask if there are other safer options for you.

                                  More on Nabumetone warnings

                                  dosage

                                  Nabumetone dosage forms

                                  The average cost for 60 tablets of 500mg of Nabumetone is $21.08 with a free GoodRx coupon. This is 64.78% off the average retail price of $59.85.
                                  tablet
                                  Tablet
                                  DosageQuantityPrice as low asPrice per unit
                                  500mg60 tablets$21.08$0.35
                                  750mg60 tablets$22.44$0.37

                                  Typical dosing for Nabumetone

                                  The typical starting dose is 1 gram by mouth taken as a single dose.

                                  For more pain relief, your prescriber might raise the dose to 1.5 grams or 2 grams per day. You can take this as a single dose or split it into two smaller doses throughout the day.

                                  interactions

                                  Interactions between Nabumetone and other drugs

                                  Nabumetone may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Nabumetone. Please note that only the generic name of each medication is listed below.

                                  Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                                  Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                  Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                                  drug-cost

                                  How much does Nabumetone cost?

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                                  contraindications-icon

                                  Nabumetone contraindications

                                  Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Nabumetone will not be safe for you to take.
                                  alternatives

                                  What are alternatives to Nabumetone?

                                  There are a number of medications that your doctor can prescribe in place of Nabumetone. Compare a few possible alternatives below.
                                  Nabumetone
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