Key takeaways
Piroxicam (Feldene) and meloxicam (Mobic, Anjeso) are both nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat pain from osteoarthritis and rheumatoid arthritis. They work by blocking proteins that cause inflammation, pain, and swelling. However, they have some differences. Piroxicam is available as an oral capsule and is typically taken once daily, while meloxicam comes in various forms, including capsules, tablets, liquid, and an injectable form that's used in the hospital. It can take 2 to 3 months to get the full effects of piroxicam. Both medications can cause serious side effects like stomach bleeding and heart problems, but meloxicam is thought to have fewer kidney and stomach side effects than many other NSAIDs. Do not take other NSAIDs, including OTC NSAIDs like ibuprofen (Motrin) or naproxen (Aleve) while you are taking either piroxicam or meloxicam.
