Key takeaways
Ibuprofen / famotidine and diclofenac (Voltaren and Pennsaid, Flector, Cambia, Lofena, Zipsor, Zorvolex) are both non-steroidal anti-inflammatory drugs (NSAIDs) used to treat conditions like osteoarthritis and rheumatoid arthritis. However, they differ in several ways. Ibuprofen / famotidine is a combination medication that includes famotidine, a histamine H2 antagonist, to help protect against stomach ulcers, while diclofenac is a standalone NSAID. Ibuprofen / famotidine is taken as a single tablet three times a day, whereas diclofenac comes in various forms, such as oral tablets, capsules, and powders, as well as patches and eye drops, with dosing that varies based on the condition being treated. Both medications are available as lower-cost generics. Ibuprofen / famotidine used to be available as brand-name Duexis, but this product was discontinued. Common side effects of ibuprofen / famotidine include nausea and high blood pressure, while diclofenac can cause headaches and dizziness. Both medications carry risks of serious side effects like heart attack, stroke, and stomach bleeding. You should avoid taking either medication with other NSAIDs to avoid increased risk of side effects.
