Compare Relafen vs. Norco

Nabumetone (Relafen) and Norco (hydrocodone/acetaminophen) are both used to manage pain, but they belong to different medication classes and work in distinct ways. Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) that helps relieve arthritis symptoms like joint pain, swelling, and stiffness by blocking the inflammatory process. It is typically taken once or twice a day and is available only by prescription. In contrast, Norco is a combination of an opioid (hydrocodone) and an analgesic (acetaminophen) that is used for pain not relieved by non-opioid medications. Norco works by attaching to opioid receptors in the brain and blocking pain chemicals. It is taken every 4 to 6 hours as needed and is a controlled substance due to its high risk of misuse and dependency. While nabumetone has a lower risk of stomach-related side effects compared to some other NSAIDs, Norco can cause serious side effects like dangerously slow breathing and liver damage if misused. Additionally, Norco requires special handling and monitoring due to its potential for addiction.