Key takeaways
Percocet (oxycodone / acetaminophen) is a prescription medication that treats severe pain that isn't relieved by non-opioid pain medications. Tylenol #3 also contains an opioid (codeine), but it also contains acetaminophen (Tylenol). It’s prescribed for mild-to-moderate pain. All opioids are controlled substances and have side effects such as sleepiness, dizziness, and constipation. More seriously, they can lead to potential misuse and overdose.
