Compare Fentanyl vs. Tylenol With Codeine

Fentanyl (generic name: fentanyl) and Tylenol with Codeine (generic name: acetaminophen/codeine) are both opioid medications used to treat pain, but they have some key differences. Fentanyl is a powerful opioid used for severe, long-term pain and is available as a transdermal patch, plus other forms including oral forms. It is only for people who are already taking other opioid medications around-the-clock. In contrast, Tylenol with Codeine is a combination of acetaminophen and codeine, used for mild-to-moderate pain and taken orally as a tablet or liquid. Fentanyl is a Schedule II controlled substance, indicating a higher potential for abuse and addiction compared to Tylenol with Codeine, which is a Schedule III controlled substance. Fentanyl requires special monitoring and is part of the REMS program due to its high risk of overdose and serious side effects, while Tylenol with Codeine also has a risk of dependence and misuse but is generally considered appropriate for short-term pain relief. Additionally, fentanyl is not recommended for use in pregnant or breastfeeding women due to severe risks, and Tylenol with Codeine carries similar warnings but is also not recommended for children under 12 or those under 18 who have had recent tonsil or adenoid surgery.