Key takeaways
Tylenol (acetaminophen) and diclofenac are medications that treat pain and fever. Diclofenac also treats inflammation, but Tylenol doesn’t. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID), but Tylenol isn’t. NSAIDs like diclofenac may be preferred versus Tylenol for arthritis pain and back pain, but they’re not a good choice for everyone. NSAIDs like diclofenac are known to have more risks than Tylenol at regular doses. Examples include nausea, heartburn, and swelling. More serious risks include stomach ulcers or bleeding, and kidney damage. NSAIDs can also raise your risk of a heart attack. However, topical diclofenac (Voltaren Arthritis Pain gel) doesn’t usually have the same risks as oral NSAIDs.
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