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Tylenol vs. Arthrotec

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Acetaminophen (Tylenol) and Arthrotec (diclofenac/misoprostol) are both used to relieve pain, but they work differently and are used for different types of pain. Acetaminophen is an over-the-counter (OTC) analgesic take can be taken as needed that helps reduce mild pain and fever, but it doesn't reduce inflammation. It's available in many forms, such as tablets and liquids, and is generally safe with few side effects. It can however cause liver damage if taken in high doses or with alcohol. Arthrotec, on the other hand, is a prescription medication used to treat pain and swelling from arthritis, especially in people at high risk for stomach ulcers. It combines diclofenac, an non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation, with misoprostol, which protects the stomach lining. Arthrotec can cause serious side effects, including heart problems and digestive tract issues, and is dangerous for pregnant women. Unlike acetaminophen, Arthrotec needs to be taken multiple times a day and requires regular monitoring by a healthcare provider.

Acetaminophen

(Tylenol)

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Arthrotec

(diclofenac / misoprostol)

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Summary for Tylenol

Over-the-counter

Acetaminophen (Tylenol) is an over-the-counter (OTC) analgesic used for pain relief and to reduce fever in adults and children. It comes in many forms, including tablets, capsules, chewable tablets, liquids, powders, and suppositories. Your dose depends on your age and the product you take. Side effects are rare when taken as directed, but could include nausea and headache. Taking too much could cause serious liver problems.

Indications for Tylenol

Pros and Cons for Tylenol

Pros

  • Very well tolerated, side effects are rare
  • Safe for both adults and children
  • Available over the counter in many different forms
  • Doesn't make you sleepy

Cons

  • Doesn't help with inflammation and swelling
  • Risk of liver damage at high doses
  • Might not work as well to treat moderate-to-severe pain
  • Can interact with alcohol and raise your risk of liver problems

Common Side Effects for Tylenol

Warnings for Tylenol

  • Liver damage
  • Accidental overdose
  • Allergic skin reactions

Summary for Arthrotec

Prescription only

Arthrotec (diclofenac / misoprostol) is a combination medication used to treat osteoarthritis (OA) and rheumatoid arthritis (RA) in non-pregnant adults. The diclofenac in Arthrotec is a non-steroidal anti-inflammatory drug (NSAID) that helps with pain and swelling, while the misoprostol is a prostaglandin E1 analog that lowers the risk of stomach and intestinal ulcers from diclofenac. Arthrotec (diclofenac / misoprostol) is taken by mouth, typically two to four times per day. Common side effects of this medication include stomach cramps (pain) and diarrhea. Avoid drinking alcohol with Arthrotec (diclofenac / misoprostol) because doing so can raise the risk of stomach bleeding.

Indications for Arthrotec

Pros and Cons for Arthrotec

Pros

  • Diclofenac works well to relieve symptoms of pain and swelling and misoprostol works well to lower the risk of stomach and intestinal ulcers and bleeding
  • Conveniently combines two medication in one pill
  • Available as a lower-cost generic

Cons

  • Needs to be taken multiple times a day
  • Not safe to take at any time of pregnancy
  • Might not be the best option if you're 65 years or older or if you have kidney, heart, liver, or bleeding problems

Common Side Effects for Arthrotec

  • Stomach pain (21%)
  • Diarrhea (19%)
  • Upset stomach or indigestion (14%)
  • Nausea (11%)
  • Gas (9%)

Warnings for Arthrotec

  • Harm to mother and unborn baby
  • Stomach bleeding
  • Heart attack and stroke
  • High blood pressure and heart failure
  • Kidney damage
  • Liver problems
  • Severe allergic reactions and skin reactions
  • Risk for bleeding

Prices with our coupons for Tylenol vs. Arthrotec

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Acetaminophen30 tablets / 325mg
$9.30-
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Diclofenac Sodium/Misoprostol60 tablets / 75mg/200mcg
$54.72$204.66
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