Skip to main content
HomeDrug Comparisons
Drug bottle and Pill

Compare Clinoril vs. Naprosyn

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Sulindac and naproxen (Naprosyn) are both non-steroidal anti-inflammatory drugs (NSAIDs) used to treat pain and inflammation. But they have several differences. Sulindac is typically prescribed for various types of arthritis and certain shoulder injuries, while naproxen is used for a broader range of conditions, including arthritis, gout, and tendonitis. Sulindac is usually taken twice daily, whereas naproxen can be taken 2 to 3 times per day, depending on the condition being treated. But both medications should be taken with food to prevent an upset stomach. Sulindac and naproxen can cause serious side effects like stomach bleeding, heart attack, and stroke. Naproxen comes as a liquid form option for those who have trouble swallowing pills. Additionally, naproxen is available over-the-counter in a lower strength (Aleve), while sulindac is only available by prescription. Both medications should be taken with caution, especially if you have heart, liver, or kidney problems.

drug combination

See more from our pharmacists

  • Sulindac
    Naproxen (Naprosyn)
  • Sulindac
    Naproxen (Naprosyn)

  • Summary of Clinoril vs. Naprosyn

    Summary for NSAID
    Prescription only

    Sulindac works well to treat pain and swelling in different types of arthritis and in certain shoulder injuries. Sulindac should be used at the lowest dose possible for the shortest duration of time to manage your symptoms. That's because it can cause serious side effects, such as stroke, heart attack, and stomach bleeds.

    Summary for NSAID
    Prescription only

    Prescription-strength naproxen (Naprosyn) is a non-steroidal anti-inflammatory drug (NSAID). It can be taken by adults and children to relieve pain and symptoms of certain conditions that cause inflammation, such as rheumatoid arthritis, osteoarthritis, or gout. Naproxen (Naprosyn) works by blocking specific proteins that cause inflammation and pain. Naproxen (Naprosyn) comes as tablet and liquid suspension that are taken by mouth, typically 2 to 3 times per day. Some common side effects include heartburn, stomach pain, and nausea.

  • Indications of Clinoril vs. Naprosyn

    Indications for
    •Osteoarthritis
    •Rheumatoid arthritis
    •Arthritis of the spine (ankylosing spondylitis)
    •Gout (gouty arthritis)
    •Sharp shoulder pain (acute subacromial bursitis and supraspinatus tendinitis)
    Indications for
    •Rheumatoid arthritis (RA)
    •Osteoarthritis (OA)
    •Ankylosing spondylitis (AS) (arthritis of the spine)
    •Polyarticular juvenile idiopathic arthritis (arthritis in children)
    •Tendonitis and bursitis
    •Gout attacks
    •Pain
    •Menstrual cramps

  • Pros and Cons of Clinoril vs. Naprosyn

    Pros and Const for NSAID
    Pros
    •Available as a less expensive generic medication
    •Works well to lower pain and inflammation
    •Lasts longer than some other NSAIDs, so you only need to take it twice daily
    Cons
    •Can cause stomach bleeding or stomach ulcers
    •Not recommended for use starting the second trimester of pregnancy or later
    •Not a good option for people with certain conditions, such as heart problems, history of stroke, or kidney problems
    Pros and Const for NSAID
    Pros
    •Works well for treating pain and inflammation
    •Effects last longer than other NSAIDs, such as ibuprofen (Advil)
    •Available as a liquid for people who have a hard time swallowing pills
    Cons
    •Can cause stomach bleeding or stomach ulcers
    •Not safe to take after 20 weeks of pregnancy
    •Might not be the best option if you're 65 years or older, or have kidney, heart, liver, or bleeding problems

  • Common Side Effects of Clinoril vs. Naprosyn

    Common Side Effects for
    •Stomach pains (10%)
    •Heartburn (3-9%)
    •Nausea (3-9%)
    •Diarrhea (3-9%)
    •Constipation (3-9%)
    •Rash (3-9%)
    •Dizziness (3-9%)
    •Headache (3-9%)
    Common Side Effects for

    The following side effects were reported in 3-9% of people in clinical studies:

    •Heartburn
    •Stomach pain
    •Constipation
    •Nausea
    •Dizziness
    •Drowsiness
    •Headache
    •Itchy skin
    •Bruising
    •Ringing in the ears
    •Swelling
    •Shortness of breath

  • Warnings of Clinoril vs. Naprosyn

    Common Side Effects for
    •Heart attack and stroke
    •Stomach bleeding and ulcers
    •High blood pressure, heart failure, and swelling of your arms and legs
    •Liver damage
    •Kidney problems
    •Swelling in the pancreas
    •Severe asthma attack
    •Severe allergic and skin reaction
    •Harm to unborn babies
    Common Side Effects for
    •Stomach bleeding
    •Heart attack and stroke
    •High blood pressure and heart failure
    •Kidney damage
    •Liver problems
    •Severe allergic reactions
    •Not for use in pregnant or breastfeeding females

  • Prices with our coupons for Clinoril vs. Naprosyn

    Learn more about Sulindac
    Learn more about Naproxen

Compare other Rheumatoid Arthritis and Osteoarthritis drugs

Clinoril vs NaprosynArthrotec vs IbuprofenArthrotec vs MobicArthrotec vs NaprosynArthrotec vs VimovoArthrotec vs VoltarenCataflam vs RelafenCelebrex vs MobicDuexis vs IbuprofenDuexis vs MobicDuexis vs NaprosynDuexis vs VimovoDuexis vs VoltarenIbuprofen vs MobicIndocin vs MobicLodine vs ArthrotecMeloxicam vs RelafenMobic vs NaprosynMobic vs UltramNaproxen vs ArthrotecRelafen vs Acetaminophen With CodeineRelafen vs ArthrotecRelafen vs CelebrexRelafen vs DiclofenacRelafen vs IbuprofenRelafen vs NaprosynToradol vs MobicTylenol vs ArthrotecTylenol vs NaprosynVoltaren Gel vs Naprosyn
View More

Browse medications

View All

Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.