Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Myfortic (mycophenolic acid) and Rapamune (sirolimus) are both immunosuppressants used to prevent kidney transplant rejection, but they have some key differences. Myfortic is taken twice a day, while Rapamune is usually taken once a day. Myfortic is specifically for kidney transplants, whereas Rapamune can also treat lymphangioleiomyomatosis (LAM), a condition affecting the lungs, kidneys, and lymphatic system. Myfortic must be taken on an empty stomach, but Rapamune can be taken with or without food, as long as you are consistent. Myfortic is available in a generic form, which can be less expensive, and is suitable for children aged 5 and older. In contrast, Rapamune is not recommended for children under 12 and can cause fertility problems. Both medications have serious side effects, including risks of cancer and infections, and should not be used during pregnancy.
Mycophenolic acid (Myfortic)
Sirolimus (Rapamune)
Mycophenolic acid (Myfortic)
Sirolimus (Rapamune)
Summary of Myfortic vs. Rapamune
Summary for Immunosuppressant
Prescription only
Mycophenolic acid (Myfortic) is a transplant medication that helps prevent rejection after a kidney transplant in people 5 years and older. It's an immunosuppressant, which means that it works by weakening the immune system. Mycophenolic acid (Myfortic) is a tablet that's taken by mouth two times a day. The tablets have a special coating on them, which can help lessen gastrointestinal-related side effects such as upset stomach and diarrhea. Your transplant team might refer to the medication by its generic name, mycophenolic acid, or by its brand name, Myfortic.
Summary for Immunosuppressant
Prescription only
Sirolimus (Rapamune) lowers the activity of your immune system to prevent rejection after a kidney transplant. It can also help with a condition that affects your lymphatic system, which is related to your immune system. Your provider will check the levels of sirolimus (Rapamune) in your blood, and this will help guide the dosing. Sirolimus (Rapamune) is available as tablets and as an oral solution, and it's usually only taken once a day. Common side effects include changes in your lab values (e.g., more cholesterol and fat in the blood, change in kidney labs), which is another reason to get your blood checked regularly while taking this medication.
Indications of Myfortic vs. Rapamune
Indications for
•Prevention of kidney transplant rejection in people 5 years and older