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Entyvio vs. Skyrizi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Vedolizumab (Entyvio) and risankizumab (Skyrizi) are both medications used to treat Crohn's disease and ulcerative colitis, but they belong to different drug classes. Vedolizumab is an integrin antagonist, while risankizumab is an interleukin antagonist. Both are injectable, biologic medications. Risankizumab is also approved for plaque psoriasis and psoriatic arthritis, whereas vedolizumab is not. Vedolizumab is typically given as an intravenous infusion every two months or as a subcutaneous injection every two weeks, while risankizumab is administered as an injection every 2 or 3 months after initial doses. Common side effects of vedolizumab include headache and joint pain, while risankizumab may cause joint pain and upper respiratory infections. Both medications can increase the risk of infections, but vedolizumab also carries a risk of serious liver problems and brain infections.

Entyvio

(vedolizumab)

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Skyrizi

(risankizumab)

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Summary for Entyvio

Prescription only

Entyvio, the brand name for vedolizumab, is an injection used to treat ulcerative colitis (UC) and Crohn's disease (CD) in adults. It belongs to a drug class called integrin antagonists that helps lower inflammation in the gut. Entyvio (vedolizumab) is an infusion that's given through the vein by a healthcare professional. After the first 2 doses, it's usually given every 2 months. If it works well, people can switch to injections under the skin every 2 weeks using prefilled syringes or pens. Side effects include headache, mild infections, and joint pain.

Indications for Entyvio

Pros and Cons for Entyvio

Pros

  • Have the option for infusions through the vein or injections under the skin after 6 weeks of treatment
  • Comes as prefilled syringes and pens for injections under the skin that can be given at home

Cons

  • IV infusions can only be given by a healthcare professional at a medical office
  • Can raise your risk of serious side effects, like infusion reactions and infections

Common Side Effects for Entyvio

Warnings for Entyvio

  • Infusion-related reactions and allergic reactions
  • Risk of serious infections
  • Risk of brain infection (progressive multifocal leukoencephalopathy)
  • Liver problems

Summary for Skyrizi

Prescription only

Skyrizi (risankizumab or risankizumab-rzaa) is an injectable medication for many inflammatory conditions. It treats plaque psoriasis in adults and children ages 6 years and up. It can also treat psoriatic arthritis, Crohn's disease, and ulcerative colitis in adults. This medication works as an interleukin antagonist to help lower inflammation. After a few starter doses, it's given every 2 or 3 months, depending on the condition being treated. Side effects include a higher risk of infection.

Indications for Skyrizi

Pros and Cons for Skyrizi

Pros

  • Given every 2 or 3 months after the starter doses (depends on your condition)
  • Can give maintenance doses at home as injections under the skin after proper training
  • Approved for children as young as 6 years old with plaque psoriasis

Cons

  • Must be given as an injection
  • Can raise the risk of infection
  • Might take several weeks to months to work fully

Common Side Effects for Skyrizi

Warnings for Skyrizi

  • Allergic reaction
  • Risk of infection
  • Rare case of liver injury
  • Caution when getting vaccines

Prices with our coupons for Entyvio vs. Skyrizi

Price Card Drug Icon
Entyvio2 cartons / prefilled pen of 108mg/0.68ml
$6,993.40$9,743.89
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Price Card Drug Icon
Skyrizi1 package / 1 pen of 150mg/ml
$20,217.99-
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