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Compare Entyvio vs. Skyrizi

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Vedolizumab (Entyvio) and risankizumab (Skyrizi) are both medications used to treat Crohn's disease and ulcerative colitis, but they belong to different drug classes. Vedolizumab is an integrin antagonist, while risankizumab is an interleukin antagonist. Both are injectable, biologic medications. Risankizumab is also approved for plaque psoriasis and psoriatic arthritis, whereas vedolizumab is not. Vedolizumab is typically given as an intravenous infusion every two months or as a subcutaneous injection every two weeks, while risankizumab is administered as an injection every 2 or 3 months after initial doses. Common side effects of vedolizumab include headache and joint pain, while risankizumab may cause joint pain and upper respiratory infections. Both medications can increase the risk of infections, but vedolizumab also carries a risk of serious liver problems and brain infections.

  • Entyvio (vedolizumab)
    Skyrizi (risankizumab)
  • Entyvio (vedolizumab)
    Skyrizi (risankizumab)

  • Summary of Entyvio vs. Skyrizi

    Summary for Integrin antagonist
    Prescription only

    Entyvio, the brand name for vedolizumab, is an injection used to treat ulcerative colitis (UC) and Crohn's disease (CD) in adults. It belongs to a drug class called integrin antagonists that helps lower inflammation in the gut. Entyvio (vedolizumab) is an infusion that's given through the vein by a healthcare professional. After the first 2 doses, it's usually given every 2 months. If it works well, people can switch to injections under the skin every 2 weeks using prefilled syringes or pens. Side effects include headache, mild infections, and joint pain.

    Summary for Interleukin antagonist
    Prescription only

    Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.

  • Indications of Entyvio vs. Skyrizi

    Indications for
    •Moderate-to-severe ulcerative colitis (UC) in adults
    •Moderate-to-severe Crohn's disease (CD) in adults
    Indications for
    •Moderate-to-severe plaque psoriasis in adults
    •Psoriatic arthritis in adults
    •Moderate-to-severe Crohn's disease in adults
    •Moderate-to-severe ulcerative colitis in adults

  • Pros and Cons of Entyvio vs. Skyrizi

    Pros and Const for Integrin antagonist
    Pros
    •Have the option for infusions through the vein or injections under the skin after 6 weeks of treatment
    •Comes as prefilled syringes and pens for injections under the skin that can be given at home
    Cons
    •IV infusions can only be given by a healthcare professional at a medical office
    •Can raise your risk of serious side effects, like infusion reactions and infections
    Pros and Const for Interleukin antagonist
    Pros
    •Given every 2 or 3 months after a couple of starter doses (depends on your condition)
    •Can give injections under the skin at home after you get trained
    Cons
    •Must be given as an injection
    •Not approved for children

  • Common Side Effects of Entyvio vs. Skyrizi

    Common Side Effects for
    •Infection in nose and throat (13%)
    •Headache (12%)
    •Joint pain (12%)
    •Nausea (9%)
    •Fever (9%)
    •Upper respiratory tract infection (7%)
    •Fatigue (6%)
    •Cough (5%)
    Common Side Effects for
    •Upper respiratory infections (13%)
    •Headache (4%)
    •Tiredness (3%)

  • Warnings of Entyvio vs. Skyrizi

    Common Side Effects for
    •Infusion-related reactions and allergic reactions
    •Risk of serious infections
    •Risk of brain infection (progressive multifocal leukoencephalopathy)
    •Liver problems
    Common Side Effects for
    •Allergic reaction
    •Risk of infection
    •Rare case of liver injury
    •Caution when getting vaccines

  • Prices with our coupons for Entyvio vs. Skyrizi

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    Learn more about Skyrizi

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