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Compare Stelara vs. Rinvoq

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Stelara (ustekinumab)
    Rinvoq (upadacitinib)
  • Stelara (ustekinumab)
    Rinvoq (upadacitinib)

  • Summary of Stelara vs. Rinvoq

    Summary for IL-12 and IL-23 antagonist
    Prescription only

    Stelara (ustekinumab) is an injectable medication used to treat autoimmune conditions like psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. As an interleukin antagonist, it works by blocking certain proteins that cause inflammation in your body, which helps reduce swelling and ease symptoms. You get it as an injection, either under your skin or through a vein, depending on your condition. Common side effects include common cold symptoms, headache, and feeling tired. This medication also has many biosimilars available.

    Summary for JAK inhibitor
    Prescription only

    Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor. It's used to treat certain inflammatory conditions, such as rheumatoid arthritis (RA), ulcerative colitis (UC), and eczema (atopic dermatitis). But it's not a first-choice option and typically only prescribed when other treatments haven't worked well. Rinvoq (upadacitinib) is taken by mouth, usually once daily. It's available as an extended-release tablet (Rinvoq) and an oral solution (Rinvoq LQ), but the two formulations aren't interchangeable. Side effects include a higher risk of infections, acne, and nausea.

  • Indications of Stelara vs. Rinvoq

    Indications for
    •Moderate-to-severe plaque psoriasis (Ps) - adults and children 6 years and older
    •Psoriatic arthritis (PsA) - adults and children 6 years and older
    •Moderate-to-severe Crohn's disease (CD)
    •Moderate-to-severe ulcerative colitis (UC)
    Indications for

    Moderate-to-severe inflammatory conditions in which other treatments haven't worked:

    •Rheumatoid arthritis (RA) in adults
    •Psoriatic arthritis (PsA) in adults and children ages 2 years and older
    •Eczema (atopic dermatitis) in adults and children ages 12 years and older
    •Ulcerative colitis (UC) in adults
    •Crohn's disease (CD) in adults
    •Ankylosing spondylitis (AS) in adults
    •Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
    •Polyarticular juvenile idiopathic arthritis (pJIA) in adults and children ages 2 years and older

  • Pros and Cons of Stelara vs. Rinvoq

    Pros and Const for IL-12 and IL-23 antagonist
    Pros
    •Isn't injected as often as other similar medications
    •Comes as a prefilled syringe for easier home administration
    •Can be stored at room temperature for up to 30 days
    •Approved for children as young as 6 years old
    Cons
    •Can weaken your immune system and raise your risk of infection
    •Potential to cause serious allergic reactions
    •For CD and UC, the first dose must be given as an IV infusion
    •Can't receive live vaccines while taking this medication
    Pros and Const for JAK inhibitor
    Pros
    •Can treat many different inflammatory conditions
    •Available as a tablet and a liquid
    •The tablet only needs to be taken once a day
    Cons
    •Can raise risk for infections
    •Not the best option for people with severe liver or kidney problems
    •Not safe for use during pregnancy

  • Common Side Effects of Stelara vs. Rinvoq

    Common Side Effects for

    Plaque psoriasis

    •Common cold symptoms (7-8%)
    •Upper respiratory tract infection (4-5%)
    •Headache (5%)

    Psoriatic arthritis

    •Joint pain (3%)
    •Nausea (3%)

    Crohn's disease

    •Common cold symptoms (11%)
    •Redness at the injection site (5%)
    •Yeast infection (5%)
    •Bronchitis (5%)

    Ulcerative colitis:

    •Common cold symptoms (24%)
    •Headache (10%)
    •Stomach pain (7%)
    •Flu infection (6%)
    •Fever (5%)
    Common Side Effects for
    •Upper respiratory tract infection (25%)
    •Acne (16%)
    •Herpes simplex virus (HSV) infection (8%)
    •Headache (6%)

    Note: Side effects listed were reported by people who took Rinvoq for eczema.

  • Warnings of Stelara vs. Rinvoq

    Common Side Effects for
    •Infections
    •Cancers
    •Severe allergic reaction
    •Brain condition
    •Vaccines
    •Lung problems
    Common Side Effects for
    •Serious infections
    •Possible higher risk of death for people with rheumatoid arthritis
    •Risk of cancer
    •Possible risk of heart attack, stroke, and other blood clots
    •Severe allergic reaction
    •Stomach and gut tears
    •Abnormal lab results (e.g., blood cell counts, cholesterol levels)
    •Possible harm to unborn babies
    •Medication in stool

  • Prices with our coupons for Stelara vs. Rinvoq

    Learn more about Stelara
    Learn more about Rinvoq

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