JAK Inhibitors

Opzelura (ruxolitinib) is used to treat mild to moderate eczema and nonsegmental vitiligo in adults and children 12 years of age and older. There are currently no generic alternatives for Opzelura. It may be covered by your Medicare or insurance plan, but some pharmacy coupons or cash prices could help offset the cost.

Rinvoq (upadacitinib) is used to treat rheumatoid arthritis, psoriatic arthritis, eczema, ulcerative colitis, Crohn's disease, ankylosing spondylitis, and non-radiographic axial spondyloarthritis. There are currently no generic alternatives to Rinvoq. It may be covered by your Medicare or insurance plan, but some pharmacy coupons or cash prices could help offset the cost.

Xeljanz (Tofacitinib) is an expensive drug that works on the immune system. This medicine is used to treat rheumatoid arthritis and psoriatic arthritis. It is also used to treat ulcerative colitis. This drug is more popular than comparable drugs. There are currently no generic alternatives to Xeljanz. While 96% of insurance plans cover the most common version of Xeljanz at a co-pay of $60.00-$83.00, many of them have restrictions. Manufacturer and pharmacy coupons can help offset the cost.

ABROCITINIB treats eczema. It is prescribed when other medications do not work well enough or cannot be tolerated. It works by slowing down an overactive immune system.

TOFACITINIB treats autoimmune conditions, such as arthritis and ulcerative colitis. It is prescribed when other medications have not worked or cannot be tolerated. It works by slowing down an overactive immune system. This decreases inflammation.

FEDRATINIB treats bone marrow cancer. It works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

The average list price of Jakafi (Ruxolitinib) is $17,150.00, but your out of pocket cost will likely be less if you have insurance. Jakafi is covered by some Medicare and insurance plans. This drug is also a limited distribution drug, meaning it is not available at retail pharmacies. Refer to the Key Takeaways for additional information on Jakafi and check our savings tips for other ways to reduce your cost. A generic version of Jakafi is not yet available.

Leqselvi is part of the JAK Inhibitors class and treats Alopecia. JAK inhibitors are used to treat several different conditions such as rheumatoid arthritis, ulcerative colitis, eczema, and myelofibrosis. They work by blocking the attachment of proteins to their receptors so that the immune system does not over produce inflammation. Leqselvi is only available as a brand name drug.

RITLECITINIB treats alopecia areata, an autoimmune condition that causes hair loss. It works by slowing down an overactive immune system.

MOMELOTINIB treats bone marrow cancer. It works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

Olumiant (baricitinib) is used to treat rheumatoid arthritis, COVID-19 and alopecia areata. It is only available as a brand drug. It is covered by some Medicare and insurance plans.