Anzupgo (delgocitinib) is a cream used to treat moderate-to-severe chronic hand eczema (CHE) in adults. It might be prescribed if topical steroids don’t work well enough or if they aren't a good option for you. Anzupgo (delgocitinib) is a Janus kinase (JAK) inhibitor that helps improve itchiness and pain caused by eczema. It’s applied twice daily to the affected areas on the hands and wrists. Side effects include tingling or redness where you apply the cream. It might also raise your risk of infections.