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Orencia vs. Actemra

Orencia (abatacept) and Actemra (tocilizumab) are used to treat autoimmune conditions like rheumatoid arthritis (RA). Orencia works by blocking certain proteins and processes in cells to lower inflammation, while Actemra blocks a chemical that causes inflammation and fever. Orencia is available as an injection, typically given weekly or monthly. Actemra can also be given as an injection or infusion, but its dosing schedule varies from weekly to every few weeks depending on the condition. Actemra has a biosimilar called Tofidence, which offers more options for treatment. Both medications raise the risk of infections, but Actemra also has warnings for liver problems and high cholesterol. Orencia is not known to cause liver issues.