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Compare Rinvoq vs. Cosentyx

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Rinvoq (upadacitinib)
    Cosentyx (secukinumab)
  • Rinvoq (upadacitinib)
    Cosentyx (secukinumab)

  • Summary of Rinvoq vs. Cosentyx

    Summary for JAK inhibitor
    Prescription only

    Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor. It's used to treat certain inflammatory conditions, such as rheumatoid arthritis (RA), ulcerative colitis (UC), and eczema (atopic dermatitis). But it's not a first-choice option and typically only prescribed when other treatments haven't worked well. Rinvoq (upadacitinib) is taken by mouth, usually once daily. It's available as an extended-release tablet (Rinvoq) and an oral solution (Rinvoq LQ), but the two formulations aren't interchangeable. Side effects include a higher risk of infections, acne, and nausea.

    Summary for Interleukin 17 (IL-17) inhibitor
    Prescription only

    Cosentyx (secukinumab) is a monoclonal antibody known as an interleukin 17 (IL-17) inhibitor. It's used to treat several inflammatory conditions, including plaque psoriasis, ankylosing spondylitis, and hidradenitis suppurativa. Cosentyx (secukinumab) comes as a pre-filled pen and syringe, and is typically injected under the skin monthly. It can also be given as an infusion through the veins by a healthcare provider for certain conditions, usually in a clinic setting. Side effects aren't common, but can include the common cold and diarrhea.

  • Indications of Rinvoq vs. Cosentyx

    Indications for

    Moderate-to-severe inflammatory conditions in which other treatments haven't worked:

    •Rheumatoid arthritis (RA) in adults
    •Psoriatic arthritis (PsA) in adults and children ages 2 years and older
    •Eczema (atopic dermatitis) in adults and children ages 12 years and older
    •Ulcerative colitis (UC) in adults
    •Crohn's disease (CD) in adults
    •Ankylosing spondylitis (AS) in adults
    •Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
    •Polyarticular juvenile idiopathic arthritis (pJIA) in adults and children ages 2 years and older
    Indications for
    •Plaque psoriasis (PsO) in people ages 6 years and older
    •Psoriatic arthritis (PsA) in people ages 2 years and older who weigh at least 33 lbs
    •Ankylosing spondylitis (AS) in adults
    •Non-radiographic axial spondyloarthritis (nr-axSpA) in adults
    •Enthesitis-related arthritis in people ages 4 years and older who weigh at least 33 lbs
    •Hidradenitis suppurativa in adults

  • Pros and Cons of Rinvoq vs. Cosentyx

    Pros and Const for JAK inhibitor
    Pros
    •Can treat many different inflammatory conditions
    •Available as a tablet and a liquid
    •The tablet only needs to be taken once a day
    Cons
    •Can raise risk for infections
    •Not the best option for people with severe liver or kidney problems
    •Not safe for use during pregnancy
    Pros and Const for Interleukin 17 (IL-17) inhibitor
    Pros
    •Works well to treat several different inflammatory problems
    •Injected monthly (after the loading doses)
    •Available as a prefilled syringe or Sensoready pen for easy at-home injections
    •Can be used in children (for plaque psoriasis, psoriatic arthritis, and enthesitis-related arthritis)
    Cons
    •Only available as injections
    •Raises the risk of infections
    •Can worsen inflammatory bowel disease (IBD) (e.g., ulcerative colitis or Crohn's disease) symptoms
    •Pens and prefilled syringes not appropriate for those with latex allergy

  • Common Side Effects of Rinvoq vs. Cosentyx

    Common Side Effects for
    •Upper respiratory tract infection (25%)
    •Acne (16%)
    •Herpes simplex virus (HSV) infection (8%)
    •Headache (6%)

    Note: Side effects listed were reported by people who took Rinvoq for eczema.

    Common Side Effects for
    •Common cold (12%)
    •Diarrhea (4%)
    •Upper respiratory infections (3%)

    Note: Side effects listed were reported by adults who took Cosentyx (secukinumab) for PsO in clinical trials.

  • Warnings of Rinvoq vs. Cosentyx

    Common Side Effects for
    •Serious infections
    •Possible higher risk of death for people with rheumatoid arthritis
    •Risk of cancer
    •Possible risk of heart attack, stroke, and other blood clots
    •Severe allergic reaction
    •Stomach and gut tears
    •Abnormal lab results (e.g., blood cell counts, cholesterol levels)
    •Possible harm to unborn babies
    •Medication in stool
    Common Side Effects for
    •Infections
    •Caution when getting vaccines
    •Allergic and skin reactions
    •Worsening of inflammatory bowel disease

  • Prices with our coupons for Rinvoq vs. Cosentyx

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    Learn more about Cosentyx

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