Key takeaways
Enbrel (etanercept) and Humira (adalimumab) are both biologic DMARDs used to treat autoimmune conditions, but they have some differences. Enbrel and Humira are both available as brand-name products and also have several biosimilars. Enbrel is typically injected once a week, whereas Humira is usually given every other week. Humira treats a broader range of conditions, including Crohn's disease, ulcerative colitis, hidradenitis suppurativa, and uveitis, which Enbrel does not. Both medications can raise the risk of serious infections and certain cancers, but they have different dosing schedules and specific side effects. Enbrel is known for causing injection site reactions and common colds, while Humira can cause headaches and sinus infections.
