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Compare Skyrizi vs. Bimzelx

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Skyrizi (risankizumab) and Bimzelx (bimekizumab) are both medications used to treat moderate-to-severe plaque psoriasis and psoriatic arthritis in adults and belong to the interleukin antagonist medication class. However, they have several differences. Skyrizi is also FDA-approved for ulcerative colitis and Crohn's disease, while Bimzelx is approved for non-radiographic axial spondyloarthritis, ankylosing spondylitis, and hidradenitis suppurativa. Skyrizi is administered as an injection every 2 or 3 months after initial doses, whereas Bimzelx is injected every month initially and then every other month. Skyrizi is available as a prefilled syringe, pen, and On-Body Injector, while Bimzelx comes as prefilled autoinjectors and syringes. Common side effects of Skyrizi include joint pain and a higher risk of infections, while Bimzelx may cause runny nose, cough, and oral thrush. Both medications require caution with live vaccines due to their effects on the immune system.

Skyrizi (risankizumab)
Bimzelx (bimekizumab)
Skyrizi (risankizumab)
Bimzelx (bimekizumab)
Summary of Skyrizi vs. Bimzelx
Summary for Interleukin antagonist
Prescription only
Skyrizi (risankizumab or risankizumab-rzaa) is an injection used to treat different inflammatory conditions in adults. This includes plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. It belongs to the drug class called interleukin antagonists. It works to lower inflammation and relieve symptoms. After the first few doses, you usually get the Skyrizi (risankizumab) injection every 2 or 3 months. This medication can raise your risk of infection as a side effect.
Summary for Interleukin antagonist
Prescription only
Bimzelx (bimekizumab or bimekizumab-bkzx) is an injection that's used to treat several inflammatory conditions in adults. They include plaque psoriasis, psoriatic arthritis, and hidradenitis suppurativa, to name a few. It's a type of monoclonal antibody called an interleukin antagonist. It works to reduce inflammation in the body. Bimzelx (bimekizumab) comes in prefilled autoinjectors or prefilled syringes. You inject the medication under the skin either every month or every other month. It can cause side effects like upper respiratory infections.
Indications of Skyrizi vs. Bimzelx
Indications for

•Moderate-to-severe plaque psoriasis in adults

•Psoriatic arthritis in adults

•Moderate-to-severe Crohn's disease in adults

•Moderate-to-severe ulcerative colitis in adults

Indications for

•Moderate-to-severe plaque psoriasis

•Psoriatic arthritis

•Non-radiographic axial spondyloarthritis

•Ankylosing spondylitis

•Moderate-to-severe hidradenitis suppurativa
Pros and Cons of Skyrizi vs. Bimzelx
Pros and Const for Interleukin antagonist
Pros

•Given every 2 or 3 months after a couple of starter doses (depends on your condition)

•Can give injections under the skin at home after you get trained

Cons

•Must be given as an injection

•Not approved for children

Pros and Const for Interleukin antagonist
Pros

•Dosing schedule is either every month or every other month, so it's convenient for most people

•An option for plaque psoriasis if topical medications have stopped working

•Available as prefilled autoinjectors and prefilled syringes

Cons

•Can cause injection reactions, such as pain, bruising, and swelling

•Might raise the risk of infections

•Unknown if safe during pregnancy or while breastfeeding
Common Side Effects of Skyrizi vs. Bimzelx
Common Side Effects for

•Upper respiratory infections (13%)

•Headache (4%)

•Tiredness (3%)

Common Side Effects for

•Upper respiratory tract infection (runny nose, sore throat; 15%)

•Oral thrush (9%)

•Headache (3%)

•Injection site reactions (redness, pain, swelling, bruising; 3%)

•Fungal skin infections (3%)
Warnings of Skyrizi vs. Bimzelx
Common Side Effects for

•Allergic reaction

•Risk of infection

•Rare case of liver injury

•Caution when getting vaccines

Common Side Effects for

•Suicidal thoughts or behavior

•Risk of infections

•Liver problems

•Inflammatory bowel disease

•Interaction with vaccines
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Compare Skyrizi vs. Bimzelx

Key takeaways

Summary of Skyrizi vs. Bimzelx

Indications of Skyrizi vs. Bimzelx

Pros and Cons of Skyrizi vs. Bimzelx

Common Side Effects of Skyrizi vs. Bimzelx

Warnings of Skyrizi vs. Bimzelx

Prices with our coupons for Skyrizi vs. Bimzelx

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